Effiectiveness of Etiotropic Therapy in Patients with Chronic Recurrent Oral Candidiasis: a Randomized Controlled Clinical Trial

Background. Effective treatment of oral candidiasis is especially relevant due to the increase in patients with recurrent fungal lesions of the oral cavity caused by the growing number of Candidaspp. strains refractory to antimycotic drugs. The paper presents the results of the study on the clinical efficacy of etiotropic therapy in patients with chronic recurrent course of oral candidiasis.Objective. To assess the effectiveness of etiotropic therapy in patients with chronic recurrent oral candidiasis.Methods. A randomized controlled clinical trial was conducted in 56 patients with chronic recurrent oral candidiasis aged 45 to 74 years. Examination and treatment of patients was performed at the Department of Dentistry of Volgograd State Medical University and at Volgograd Regional Clinical Dental Polyclinic (Volgograd, Russia). Study timeline: September 2020 — November 2022. Patients were divided into 2 groups depending on the antimycotic drug used: in the main group, patients took voriconazole, in the control group — fluconazole. In addition to etiotropic therapy, patients of both groups were prescribed complex treatment aimed at stimulating the immune protection of the body, restoring vitamin and mineral deficiency, and correcting the imbalance of the oral ecosystem. The patients underwent local symptomatic therapy: antiseptic treatment with 0.06% chlorhexidine bigluconate solution, anesthesia with 15% lidocaine gel, and 3.44% retinol oil solution to stimulate epithelization. Oral sanitation and professional hygiene were recommended for patients to prevent oral candidiasis. In order to restore chewing function, patients were referred to prosthodontic treatment. The main reference point of the study was to assess the effectiveness of the therapy, both by clinical criteria and by evaluating the results of bacterial culture test in order to record the quantitative, species and susceptibility profile of Candidaspp. strains in 3 weeks, 6 and 12 months after the end of treatment. Analysis and statistical processing of the obtained data were performed using Excel program to MS Windows 10 (Microsoft Corp., USA).Results. The most common pathogenic agent of chronic recurrent forms of oral candidiasis is C. albicans (69.6%), followed by C. non-albicans species — C. krusei (10.7%), C. tropicalis (10.7%) and C. glabrata (8.9%). Analysis of the quantitative characteristics of Candidaspp. using bacterial culture test revealed a high and moderate number of Candidaspp. CFU in most clinical isolates before treatment, and no such cases in patients of the main group after treatment. The susceptibility test of yeast fungi to fluconazole and itraconazole showed the presence of isolates with dose-dependent susceptibility, and the resistance of individual samples C. krusei to fluconazole and C. glabrata (16.7% and 60%, respectively) and to itraconazole (33.3% and 100%, respectively). All Candidaspp. isolates were found to be highly susceptible to voriconazole. The efficacy of the combined treatment of an episode with voriconazole is 95.4%. Continued suppressive therapy with voriconazole resulted in relapse prevention in 98.3% of patients. Etiotropic therapy with voriconazole provided a stable clinical effect (92.7%) after a year of follow-up.Conclusion. The results of the study confirm the effectiveness of etiotropic therapy with voriconazole for chronic oral candidiasis complicated by a recurrent course, especially in case of detected C. non-albicans or fluconazole- and itraconazole-resistant C. albicans, or if it is impossible to identify the pathogenic agent

Weak Turbulent Kolmogorov Spectrum for Surface Gravity Waves

We study the long-time evolution of gravity waves on deep water exited by the stochastic external force concentrated in moderately small wave numbers. We numerically implement the primitive Euler equations for the potential flow of an ideal fluid with free surface written in canonical variables, using expansion of the Hamiltonian in powers of nonlinearity of up to fourth order terms. We show that due to nonlinear interaction processes a stationary energy spectrum close to $|k| \sim k^{-7/2}$ is formed. The observed spectrum can be interpreted as a weak-turbulent Kolmogorov spectrum for a direct cascade of energy.Comment: 4 pages, 5 figure

The EMCCD-Based Speckle Interferometer of the BTA 6-m Telescope: Description and First Results

The description is given for the speckle interferometer of the BTA 6-m telescope of the SAO RAS based on a new detector with an electron multiplication CCD. The main components of the instrument are microscope objectives, interference filters and atmospheric dispersion correction prisms. The PhotonMAX-512B CCD camera using a back-illuminated CCD97 allows up to 20 speckle images (with 512$\times$512 pix resolution) per second storage on the hard drive. Due to high quantum efficiency (93% in the maximum at 550 nm), and high transmission of its optical elements, the new camera can be used for diffraction-limited (0.02$''$) image reconstruction of $15^{m}$ stars under good seeing conditions. The main advantages of the new system over the previous generation BTA speckle interferometer are examined.Comment: 18 pages, 14 figure

Speckle Interferometry of Metal-Poor Stars in the Solar Neighborhood.II

The results of speckle interferometric observations of 115 metal-poor stars [m/H]<-1 within 250 pc from the Sun and with proper motions mu <= 0.2"/yr, made with the 6-m telescope of the Special Astrophysical Observatory of the Russian Academy of Sciences, are reported. Close companions with separations ranging from 0.034" to 1" were observed for 12 objects - G76-21, G59-1, G63-46, G135-16, G168-42, G141-47, G142-44, G190-10, G28-43, G217-8, G130-7, and G89-14 - eight of them are astrometrically resolved for the first time. The newly resolved systems include one triple star - G190-10. If combined with spectroscopic and visual data, our results imply a single:binary:triple:quadruple star ratio of 147:64:9:1 for a sample of 221 primary components of halo and thick-disk stars