Longevity and mortality in Kennel Club registered dog breeds in the UK in 2014

Abstract Background The domestic dog is one of the most diverse mammalian species, exhibiting wide variations in morphology, behaviour and morbidity across breeds. Therefore, it is not unexpected that breeds should also exhibit variation in mortality and longevity. While shorter longevity per se may not necessarily be a welfare issue, a generally foreshortened lifespan in a breed that is accompanied by a high prevalence of a particular cause of death may reveal potentially serious welfare concerns and highlight scope to improve breed welfare. Survey data gathered directly from owners offer useful insights into canine longevity and mortality that can support the overall evidence base for welfare reforms within breeds. Results Mortality data on 5663 deceased dogs registered with the UK Kennel Club were collected from an owner-based survey. The most commonly reported causes of death were old age (13.8%), unspecified cancer (8.7%) and heart failure (4.9%); with 5.1% of deaths reported as unknown cause. Overall median age at death was 10.33 years (interquartile range: 7.17–12.83 years). Breeds varied widely in median longevity overall from the West Highland Terrier (12.71 years) to the Dobermann Pinscher (7.67 years). There was also wide variation in the prevalence of some common causes of death among breeds, and in median longevity across the causes of death. Conclusion Substantial variation in the median lifespan and the prominent causes of death exists across breeds. This study has identified some breeds with both a low median lifespan and also a high proportional mortality for one or more specific causes of death that should be considered as both potential welfare concerns as well as opportunities for improvement

Large-scale survey to estimate the prevalence of disorders for 192 Kennel Club registered breeds

Abstract Background Pedigree or purebred dogs are often stated to have high prevalence of disorders which are commonly assumed to be a consequence of inbreeding and selection for exaggerated features. However, few studies empirically report and rank the prevalence of disorders across breeds although such data are of critical importance in the prioritisation of multiple health concerns, and to provide a baseline against which to explore changes over time. This paper reports an owner survey that gathered disorder information on Kennel Club registered pedigree dogs, regardless of whether these disorders received veterinary care. This study aimed to determine the prevalence of disorders among pedigree dogs overall and, where possible, determine any variation among breeds. Results This study included morbidity data on 43,005 live dogs registered with the Kennel Club. Just under two thirds of live dogs had no reported diseases/conditions. The most prevalent diseases/conditions overall were lipoma (4.3%; 95% confidence interval 4.13-4.52%), skin (cutaneous) cyst (3.1%; 2.94-3.27%) and hypersensitivity (allergic) skin disorder (2.7%; 2.52-2.82%). For the most common disorders in the most represented breeds, 90 significant differences between the within breed prevalence and the overall prevalence are reported. Conclusion The results from this study have added vital epidemiological data on disorders in UK dogs. It is anticipated that these results will contribute to the forthcoming Breed Health & Conservation Plans, a Kennel Club initiative aiming to assist in the identification and prioritisation of breeding selection objectives for health and provide advice to breeders/owners regarding steps that may be taken to minimise the risk of the disease/disorders. Future breed-specific studies are recommended to report more precise prevalence estimates within more breeds

Molecular Simulations of Model Bilayers of Skin Lipids

The lipid matrix within the SC is believed to be the main contributor to the skin's barrier properties. But the major problem is that the organisation of the lipids into the lamellar layers and their contribution to the barrier properties of the skin remains poorly understood. This thesis has attempted to address this issue through the use of molecular simulations of model bilayers of the SC under a variety of different conditions. The use of molecular dynamics simulations has allowed these membranes to be studied at the atomistic level that isn't accessible through conventional experiments. It is shown that the hydration level within the lipid matrix has a direct impact on the bilayer conformation and thus the barrier properties of the SC. At low hydration a pooling effect is observed on the bilayer surface, which affects the order and orientation of the CERs. Lowering the hydration reduces the amount of CER-water hydrogen bonds and replaces them with adjacent CER-CER hydrogen bonds. The lateral hydrogen bonding network remains unchanged. Through free energy calculations and the calculation of permeability coefficients, a mixed system of CER and OA has a greater permeability than either of its pure counterparts and thus would be a more favourable pathway for permeants, such as water, to migrate through. This enhanced permeability is shown to be due a combination of weakening the lateral hydrogen bonding network and disrupting the packing with it's 'kinked' tail. Finite size and solvent effects on CG simulations with the interaction of DMSO on CER bilayers are presented. At low solvent to lipid ratios and larger bilayers, the small solvent chamber allows interactions of the CER bilayer with it's periodic image causing disruption to the conformation and leading to a change to a hexagonal phase. Solvent effects are observed when the amount of DMSO at the interface is higher for larger bilayer systems despite the same solvent to lipid ratio as a larger surface area can accommodate a greater number of DMSO molecules at the interface. Our results suggest that the system sizes of at least 256 lipids and 30 solvent molecules per lipid are required to avoid finite size effects in simulations of lipid membranes in mixed solvents

Radiative corrections for (e,e′p) reactions at GeV energies

A general framework for applying radiative corrections to (e,e′p) coincidence reactions at GeV energies is presented, with special emphasis to higher-order bremsstrahlung effects, radiation from the scattered hadron, and the validity of peaking approximations. The sensitivity to the assumptions made in practically applying radiative corrections to (e,e′p) data is extensively discussed. The general framework is tested against experimental data of the 1H(e,e′p) reaction at momentum transfer values larger than 1.0 (GeV/c)^2, where radiative processes become a dominant source of uncertainty. The formulas presented here can easily be modified for any other electron-induced coincidence reaction

Ethanol induces the formation of water-permeable defects in model bilayers of skin lipids

We show that ethanol can induce the formation of water-permeable defects in model membranes of skin, providing a fresh perspective on ethanol as a membrane modulator. We rationalise our findings in terms of the chemical nature of ethanol, i.e., a combination of its hydrogen bonding propensity and amphiphilic character

Momentum Transfer Dependence of Nuclear Transparency from the Quasielastic ^(12)C(e, e'p) Reaction

The cross section for quasielastic ^(12)C(e,e’p) scattering has been measured at momentum transfer Q^2=1, 3, 5, and 6.8 (GeV/c)^2. The results are consistent with scattering from a single nucleon as the dominant process. The nuclear transparency is obtained and compared with theoretical calculations that incorporate color transparency effects. No significant rise of the transparency with Q^2 is observed

Perfect fluids from high power sigma-models

Certain solutions of a sextic sigma-model Lagrangian reminiscent of Skyrme model correspond to perfect fluids with stiff matter equation of state. We analyse from a differential geometric perspective this correspondence extended to general barotropic fluids.Comment: 17 pages. Version published in IJGMMP 8 (2011). Added Example 3.4 and 1 referenc

Thin ice clouds in the Arctic: cloud optical depth and particle size retrieved from ground-based thermal infrared radiometry

Multiband downwelling thermal measurements of zenith sky radiance, along with cloud boundary heights, were used in a retrieval algorithm to estimate cloud optical depth and effective particle diameter of thin ice clouds in the Canadian High Arctic. Ground-based thermal infrared (IR) radiances for 150 semitransparent ice clouds cases were acquired at the Polar Environment Atmospheric Research Laboratory (PEARL) in Eureka, Nunavut, Canada (80° N, 86° W). We analyzed and quantified the sensitivity of downwelling thermal radiance to several cloud parameters including optical depth, effective particle diameter and shape, water vapor content, cloud geometric thickness and cloud base altitude. A lookup table retrieval method was used to successfully extract, through an optimal estimation method, cloud optical depth up to a maximum value of 2.6 and to separate thin ice clouds into two classes: (1) TIC1 clouds characterized by small crystals (effective particle diameter  ≤  30 µm), and (2) TIC2 clouds characterized by large ice crystals (effective particle diameter  >  30 µm). The retrieval technique was validated using data from the Arctic High Spectral Resolution Lidar (AHSRL) and Millimeter Wave Cloud Radar (MMCR). Inversions were performed over three polar winters and results showed a significant correlation (R2 =  0.95) for cloud optical depth retrievals and an overall accuracy of 83 % for the classification of TIC1 and TIC2 clouds. A partial validation relative to an algorithm based on high spectral resolution downwelling IR radiance measurements between 8 and 21 µm was also performed. It confirms the robustness of the optical depth retrieval and the fact that the broadband thermal radiometer retrieval was sensitive to small particle (TIC1) sizes

What is the topology of a Schwarzschild black hole?

We investigate the topology of Schwarzschild's black hole through the immersion of this space-time in spaces of higher dimension. Through the immersions of Kasner and Fronsdal we calculate the extension of the Schwarzschild's black hole.Comment: 7 pages. arXiv admin note: substantial text overlap with arXiv:1102.446

Evidence for virtual Compton scattering from the proton

In virtual Compton scattering an electron is scattered off a nucleon such that the nucleon emits a photon. We show that these events can be selected experimentally, and present the first evidence for virtual Compton scattering from the proton in data obtained at the Stanford Linear Accelerator Center. The angular and energy dependence of the data is well described by a calculation that includes the coherent sum of electron and proton radiation