32 research outputs found
ΠΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΡ ΠΎΡΡΡΠΎΠ³ΠΎ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΡΡΡΠ΅ΡΡ-ΡΠΈΠ½Π΄ΡΠΎΠΌΠ°: ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ ΠΈ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΈΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ
The review analyzes the results of modern clinical and experimental studies on the search and informative value of biomarkers for acute respiratory distress syndrome (ARDS). It describes ARDS biomarkers of the main morphological changes in the lungs and severity of the systemic inflammatory response syndrome. Biomarkers of injury of bronchial epithelium, alveolar epithelium, vascular endothelium and pulmonary extracellular matrix were analyzed to determine the most informative indicators of ARDS of different etiology. It was found that for diagnosis and prognosis of the course of ARDS, the following biomarkers were the most informative: interleukin-6, a soluble form of the receptor for advanced glycation end products (sRAGE), surfactant protein D, protein KL-6, vascular endothelial growth factor, and angiopoietin-2. Using a multimarker panel for simultaneous determination of these indicators can promote rapid diagnostics of ARDS.Π ΠΎΠ±Π·ΠΎΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
ΠΏΠΎΠΈΡΠΊΡ ΠΈ ΠΎΡΠ΅Π½ΠΊΠ΅ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΠΎΡΡΠΈ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΠΎΡΡΡΠΎΠ³ΠΎ ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π΄ΠΈΡΡΡΠ΅ΡΡ-ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° (ΠΠ ΠΠ‘). ΠΡΠΈΠ²Π΅Π΄Π΅Π½Ρ ΡΠ²Π΅Π΄Π΅Π½ΠΈΡ ΠΎ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠ°Ρ
ΠΠ ΠΠ‘, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΡ
ΠΎΡΠ½ΠΎΠ²Π½ΡΠ΅ ΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ Π»Π΅Π³ΠΊΠΈΡ
ΠΈ ΡΡΠ΅ΠΏΠ΅Π½Ρ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΡΡΠΈ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ° ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠ³ΠΎ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ°. Π‘ ΡΠ΅Π»ΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ²Π½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΠΠ ΠΠ‘ ΡΠ°Π·Π»ΠΈΡΠ½ΠΎΠΉ ΡΡΠΈΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠ°Ρ
, ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΡΡΡΠΈΡ
ΠΎ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΈ Π±ΡΠΎΠ½Ρ
ΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ, Π°Π»ΡΠ²Π΅ΠΎΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΡΠΏΠΈΡΠ΅Π»ΠΈΡ, ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΡ ΡΠΎΡΡΠ΄ΠΎΠ² ΠΈ ΡΠΊΡΡΡΠ°ΡΠ΅Π»Π»ΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ° Π»Π΅Π³ΠΊΠΈΡ
. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ ΠΏΡΠΎΠ³Π½ΠΎΠ·Π° ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΠ ΠΠ‘ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠΈΠΌ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΠΎΠΌ ΠΎΠ±Π»Π°Π΄Π°ΡΡ: ΠΈΠ½ΡΠ΅ΡΠ»Π΅ΠΉΠΊΠΈΠ½-6, ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΠ°Ρ ΡΠΎΡΠΌΠ° ΡΠ΅ΡΠ΅ΠΏΡΠΎΡΠ° ΠΊΠΎΠ½Π΅ΡΠ½ΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² Π³Π»ΠΈΠΊΠΎΠ·ΠΈΠ»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ (sRAGE), ΡΡΡΡΠ°ΠΊΡΠ°Π½ΡΠ½ΡΠΉ Π±Π΅Π»ΠΎΠΊ D, Π±Π΅Π»ΠΎΠΊ KL-6, ΡΠ°ΠΊΡΠΎΡ ΡΠΎΡΡΠ° ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΡ ΡΠΎΡΡΠ΄ΠΎΠ², Π°Π½Π³ΠΈΠΎΠΏΠΎΡΡΠΈΠ½-2. ΠΠ»Ρ ΡΠΊΡΠΏΡΠ΅ΡΡ-Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΠ ΠΠ‘ ΡΠ»Π΅Π΄ΡΠ΅Ρ ΡΡΠΈΡΠ°ΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΌ ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠ΅ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠ΅ΡΠ΅ΡΠΈΡΠ»Π΅Π½Π½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ, ΠΊΠΎΡΠΎΡΠΎΠ΅ ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΠ΅Π°Π»ΠΈΠ·ΠΎΠ²Π°Π½ΠΎ Π² Π²ΠΈΠ΄Π΅ ΠΌΡΠ»ΡΡΠΈΠΌΠ°ΡΠΊΠ΅ΡΠ½ΠΎΠΉ ΠΏΠ°Π½Π΅Π»ΠΈ
Biomarkers of acute respiratory distress syndrome: problems and prospects of their application
The review analyzes the results of modern clinical and experimental studies on the search and informative value of biomarkers for acute respiratory distress syndrome (ARDS). It describes ARDS biomarkers of the main morphological changes in the lungs and severity of the systemic inflammatory response syndrome. Biomarkers of injury of bronchial epithelium, alveolar epithelium, vascular endothelium and pulmonary extracellular matrix were analyzed to determine the most informative indicators of ARDS of different etiology. It was found that for diagnosis and prognosis of the course of ARDS, the following biomarkers were the most informative: interleukin-6, a soluble form of the receptor for advanced glycation end products (sRAGE), surfactant protein D, protein KL-6, vascular endothelial growth factor, and angiopoietin-2. Using a multimarker panel for simultaneous determination of these indicators can promote rapid diagnostics of ARDS