C1 inhibitor deficiency: 2014 United Kingdom consensus document

C1 inhibitor deficiency is a rare disorder manifesting with recurrent attacks of disabling and potentially life-threatening angioedema. Here we present an updated 2014 United Kingdom consensus document for the management of C1 inhibitor-deficient patients, representing a joint venture between the United Kingdom Primary Immunodeficiency Network and Hereditary Angioedema UK. To develop the consensus, we assembled a multi-disciplinary steering group of clinicians, nurses and a patient representative. This steering group first met in 2012, developing a total of 48 recommendations across 11 themes. The statements were distributed to relevant clinicians and a representative group of patients to be scored for agreement on a Likert scale. All 48 statements achieved a high degree of consensus, indicating strong alignment of opinion. The recommendations have evolved significantly since the 2005 document, with particularly notable developments including an improved evidence base to guide dosing and indications for acute treatment, greater emphasis on home therapy for acute attacks and a strong focus on service organisation. This article is protected by copyright. All rights reserved

Autocompensating Quantum Cryptography

Quantum cryptographic key distribution (QKD) uses extremely faint light pulses to carry quantum information between two parties (Alice and Bob), allowing them to generate a shared, secret cryptographic key. Autocompensating QKD systems automatically and passively compensate for uncontrolled time dependent variations of the optical fiber properties by coding the information as a differential phase between orthogonally-polarized components of a light pulse sent on a round trip through the fiber, reflected at mid-course using a Faraday mirror. We have built a prototype system based on standard telecom technology that achieves a privacy-amplified bit generation rate of ~1000 bits/s over a 10-km optical fiber link. Quantum cryptography is an example of an application that, by using quantum states of individual particles to represent information, accomplishes a practical task that is impossible using classical means.Comment: 18 pages, 6 figures, 1 table. Submitted to the New Journal of Physic

Performance of various quantum key distribution systems using 1.55 um up-conversion single-photon detectors

We compare the performance of various quantum key distribution (QKD) systems using a novel single-photon detector, which combines frequency up-conversion in a periodically poled lithium niobate (PPLN) waveguide and a silicon avalanche photodiode (APD). The comparison is based on the secure communication rate as a function of distance for three QKD protocols: the Bennett-Brassard 1984 (BB84), the Bennett, Brassard, and Mermin 1992 (BBM92), and the coherent differential phase shift keying (DPSK). We show that the up-conversion detector allows for higher communication rates and longer communication distances than the commonly used InGaAs/InP APD for all the three QKD protocols.Comment: 9 pages, 9 figure

Practical quantum key distribution: On the security evaluation with inefficient single-photon detectors

Quantum Key Distribution with the BB84 protocol has been shown to be unconditionally secure even using weak coherent pulses instead of single-photon signals. The distances that can be covered by these methods are limited due to the loss in the quantum channel (e.g. loss in the optical fiber) and in the single-photon counters of the receivers. One can argue that the loss in the detectors cannot be changed by an eavesdropper in order to increase the covered distance. Here we show that the security analysis of this scenario is not as easy as is commonly assumed, since already two-photon processes allow eavesdropping strategies that outperform the known photon-number splitting attack. For this reason there is, so far, no satisfactory security analysis available in the framework of individual attacks.Comment: 11 pages, 6 figures; Abstract and introduction extended, Appendix added, references update

A high-performance integrated single-photon detector for telecom wavelengths

We have integrated a commercial avalanche photodiode (APD) and the circuitry needed to operate it as a single-photon detector (SPD) onto a single PC-board. At temperatures accessible with Peltier coolers (~200-240K), the PCB-SPD achieves high detection efficiency (DE) at 1308 and 1545 nm with low dark count probability (e.g. ~10-6/bias pulse at DE=20%, 220 K), making it useful for quantum key distribution (QKD). The board generates fast bias pulses, cancels noise transients, amplifies the signals, and sends them to an on-board discriminator. A digital blanking circuit suppresses afterpulsing.Comment: (10 pages, 6 figures

Theory of Spontaneous Polarization of Endohedral Fullerenes

A pseudo-Jahn-Teller model describing central atom distortions is proposed for endohedral fullerenes of the form A@C$_{60}$ where A is either a rare gas or a metal atom. A critical (dimensionless) coupling $g_c$ is found, below which the symmetric configuration is stable and above which inversion symmetry is broken. Vibronic parameters are given for selected endohedral fullerenes.Comment: 4 pages, REVTEX, 1 Postscript figure. [Phys. Rev. Lett. (in press)

Comparison of Bond Character in Hydrocarbons and Fullerenes

We present a comparison of the bond polarizabilities for carbon-carbon bonds in hydrocarbons and fullerenes, using two different models for the fullerene Raman spectrum and the results of Raman measurements on ethane and ethylene. We find that the polarizabilities for single bonds in fullerenes and hydrocarbons compare well, while the double bonds in fullerenes have greater polarizability than in ethylene.Comment: 7 pages, no figures, uses RevTeX. (To appear in Phys. Rev. B.

Experimental implementation of time-coding quantum key distribution

We have implemented an experimental set-up in order to demonstrate the feasibility of time-coding protocols for quantum key distribution. Alice produces coherent 20 ns faint pulses of light at 853 nm. They are sent to Bob with delay 0 ns (encoding bit 0) or 10 ns (encoding bit 1). Bob directs at random the received pulses to two different arms. In the first one, a 300 ps resolution Si photon-counter allows Bob to precisely measure the detection times of each photon in order to establish the key. Comparing them with the emission times of the pulses sent by Alice allows to evaluate the quantum bit error rate (QBER). The minimum obtained QBER is 1.62 %. The possible loss of coherence in the set-up can be exploited by Eve to eavesdrop the line. Therefore, the second arm of Bob set-up is a Mach-Zender interferometer with a 10 ns propagation delay between the two path. Contrast measurement of the output beams allows to measure the autocorrelation function of the received pulses that characterizes their average coherence. In the case of an ideal set-up, the value expected with the pulses sent by Alice is 0.576. The experimental value of the pulses autocorrelation function is found to be 0.541. Knowing the resulting loss of coherence and the measured QBER, one can evaluate the mutual information between Alice and Eve and the mutual information between Alice and Bob, in the case of intercept-resend attacks and in the case of attacks with intrication. With our values, Bob has an advantage on Eve of 0.43 bit per pulse. The maximum possible QBER corresponding to equal informations for Bob and Eve is 5.8 %. With the usual attenuation of fibres at 850 nm, it shows that secure key distribution is possible up to a distance of 2.75 km, which is sufficient for local links.Comment: 27 pages, 6 figure

Field-effect transistors assembled from functionalized carbon nanotubes

We have fabricated field effect transistors from carbon nanotubes using a novel selective placement scheme. We use carbon nanotubes that are covalently bound to molecules containing hydroxamic acid functionality. The functionalized nanotubes bind strongly to basic metal oxide surfaces, but not to silicon dioxide. Upon annealing, the functionalization is removed, restoring the electronic properties of the nanotubes. The devices we have fabricated show excellent electrical characteristics.Comment: 5 pages, 6 figure

Electronic and Magnetic Properties of Partially-Open Carbon Nanotubes

On the basis of the spin-polarized density functional theory calculations, we demonstrate that partially-open carbon nanotubes (CNTs) observed in recent experiments have rich electronic and magnetic properties which depend on the degree of the opening. A partially-open armchair CNT is converted from a metal to a semiconductor, and then to a spin-polarized semiconductor by increasing the length of the opening on the wall. Spin-polarized states become increasingly more stable than nonmagnetic states as the length of the opening is further increased. In addition, external electric fields or chemical modifications are usable to control the electronic and magnetic properties of the system. We show that half-metallicity may be achieved and the spin current may be controlled by external electric fields or by asymmetric functionalization of the edges of the opening. Our findings suggest that partially-open CNTs may offer unique opportunities for the future development of nanoscale electronics and spintronics.Comment: 6 figures, to appear in J. Am. Chem. So