On the Modulational Instability of the Nonlinear Schr\"odinger Equation with Dissipation

The modulational instability of spatially uniform states in the nonlinear Schr\"odinger equation is examined in the presence of higher-order dissipation. The study is motivated by results on the effects of three-body recombination in Bose-Einstein condensates, as well as by the important recent work of Segur et al. on the effects of linear damping in NLS settings. We show how the presence of even the weakest possible dissipation suppresses the instability on a longer time scale. However, on a shorter scale, the instability growth may take place, and a corresponding generalization of the MI criterion is developed. The analytical results are corroborated by numerical simulations. The method is valid for any power-law dissipation form, including the constant dissipation as a special case

Soliton Dynamics in Linearly Coupled Discrete Nonlinear Schr\"odinger Equations

We study soliton dynamics in a system of two linearly coupled discrete nonlinear Schr\"odinger equations, which describe the dynamics of a two-component Bose gas, coupled by an electromagnetic field, and confined in a strong optical lattice. When the nonlinear coupling strengths are equal, we use a unitary transformation to remove the linear coupling terms, and show that the existing soliton solutions oscillate from one species to the other. When the nonlinear coupling strengths are different, the soliton dynamics is numerically investigated and the findings are compared to the results of an effective two-mode model. The case of two linearly coupled Ablowitz-Ladik equations is also investigated.Comment: to be published in Mathematics and Computers in Simulation, proceedings of the fifth IMACS International Conference on Nonlinear Evolution Equations and Wave Phenomena: Computation and Theory (Athens, Georgia - April 2007

Development of a Pilot Borehole Storage System of Solar Thermal Energy: Modeling, Design, and Installation

Borehole thermal energy storage systems represent a potential solution to increase the energy efficiency of renewable energy plants, but they generally have to comply with strict regulatory frameworks, mainly due to the deliberate modification of the subsoil’s natural state. This paper presents the design, testing, and monitoring phases carried out to set up a borehole thermal energy storage (BTES) system able to exploit the excess solar heat from photovoltaic thermal (PVT) collectors. The case study is the refurbishment of a pig nursery barn, hosting up to 2500 weaners, in Northern Italy. This study aims to define a BTES suitable to develop a heating system based on renewable energy, ensuring environmental protection and long-term sustainability. The retrofitting intervention includes the installation of a dual-source heat pump (DSHP), in order to recover the solar heat stored in summer during winter. Specific constraints by the Environmental Authority were as follows: maximum storage temperature of 35 °C, authorization to intercept the shallowest aquifer at a maximum depth of 30 m, obligation of BHE grouting, and the definition of a strategy for continuous measuring and monitoring of the groundwater’s thermophysical properties. The results were used as inputs to optimize the design and installation of the integrated system with PVT, BTES, and DSHP

Impacts of desalinated and recycled water in the Abu Dhabi surficial aquifer

In Abu Dhabi, one of the most arid regions in the world, in recent decades, desalinated water has been identified as a prime solution in solving the water demand issues. In this study, a three-dimensional coupled density-dependent flow and solute transport model was set up in order to study the effect of the artificial recharge using desalinated water and the influence of nonconventional water with a salt concentration in the range 0.1–2 g/L The results confirm that this region demands the adoption of a more rational use of irrigation water or additional usage of desalinated water and recycled water together with optimizing groundwater pumping at locations that are vulnerable to further quality degradation and depletion. The long-term storage of desalinated freshwater with a maximum radial distance of 653 m in the dune surface is ensured with the formation of the transition zone, and change in the groundwater head up to 5 km. The maximum recovery obtained by immediate recovery is 70%. The study expresses the long-term feasibility of desalinated freshwater storage and the need for further management practices in quantifying the contribution of desalinated and recycled water for agriculture activities which might have improved groundwater quality and increased hydraulic head at some locations

Experimental study of forced convection heat transport in porous media

Abstract. The present study is aimed at extending this thematic issue through heat transport experiments and their interpretation at laboratory scale. An experimental study to evaluate the dynamics of forced convection heat transfer in a thermally isolated column filled with porous medium has been carried out. The behavior of two porous media with different grain sizes and specific surfaces has been observed. The experimental data have been compared with an analytical solution for one-dimensional heat transport for local nonthermal equilibrium condition. The interpretation of the experimental data shows that the heterogeneity of the porous medium affects heat transport dynamics, causing a channeling effect which has consequences on thermal dispersion phenomena and heat transfer between fluid and solid phases, limiting the capacity to store or dissipate heat in the porous medium

Preliminary TL and OSL investigations of obsidian samples

Obsidian is a volcaniclastic mineral extremely hard to break, which was used in prehistoric Greece (and elsewhere in the World), in order to provide tools, weapons, knives and arrowheads. The present work aims to characterize this extremely precious tool stone by using both thermoluminescence (TL) and optically stimulated luminescence (OSL) techniques and investigate its potential use for luminescence dating purposes. Basic TL and OSL properties, such as TL and OSL thermal and optical stability, repeatability, TL and LM-OSL glow curve shape and mainly the linearity of the TL and OSL signals as a function of beta dose were investigated. Artificially irradiated samples indicate all promising luminescence features, such as the 110 degrees C TL peak and dose response sub-linearity for intermediate doses, quick and effective bleaching all over the entire TL glow curve, along with quite linear CW-OSL dose response for doses larger than 5 Gy. The lack of predose sensitisation indicates the suitability of the material for single aliquot measurements. Furthermore, several features provide indications that the signal does not relate to quartz, but in fact to other silicates. Unfortunately, both lack of bleaching ability for NIL signal, along with a peculiar shape of NOSL, provide major difficulties in dating applications.Publisher's Versio

Conformational Changes in an Epitope Localized to the NH2-terminal Region of Protein C

Murine monoclonal antibodies, developed following immunization with human protein C, were characterized for their ability tboin d antigen in thpe resence of either CaClz or excess EDTA. Three stablec lones were obtained which produced antiboditehsa t bound to protein C only itnh e presence of EDTA. Allt hree antibodies bound to the light choafi np rotein C on immunoblots and also bound to the homologous proteins factor X and prothrombin in solid-phase radioimmunoassays. One antibody, 7D7B10 was purified and studied further. The binding of 7D7B10 to human protein C was characterized bya KOo f 1.4 nM. In competition studies, it was found that the relative affinityo f the antibody for protein C was 20-40-fold higher than for prothrombin, fragment 1 of prothrombin, or factor X. In contrast, 7D7B10 was unable to bind to factor 1X or bovine protein C. The effect of varying Ca2+ concentration on the interaction of the antibody with protein C was complex. Low concentrations of Ca2+ enhanced the formation of the protein C-antibody complex with half-maximal effect occurring at approximately6 0 PM metal ion. However, higher concentrations of Ca2+ completely inhibited 7D7B10 binding to protein C with a K o .o~f 1.1 mM. Furthermore, millimolar concentrations of Mn2+, Ba2+, or Mg2+ also completely abolished antibody binding to protein C. The location of the epitope was delineatedby immunoblotting and peptide studies andf ound to be present in the NHz-termin1a5l residues of protein C. Although residues corresponding to positions 10-13 of human protein C wernee cessary for maximal binding of the antibody, they were not sufficient. No evidence could be found for involvement of the epitope in metal binding per se. Therefore, the effect of Ca2+ on antibody binding is thought to be due to metal-dependent conformational changes in protein C. It seems likelyth at Ca2+ occupatioonf a high affinity site, shown by others to be located in the epidermal growth factor-like domain, causes a conformational change in the NHz-terminarel gion of protein C which is favorable for antibody interaction, whereas Ca2+ binding to thleo w affinity site($, known to be present in the y-carboxyglutamic acid domain, causes an unfavorable conformational change

Modulational and Parametric Instabilities of the Discrete Nonlinear Schr\"odinger Equation

We examine the modulational and parametric instabilities arising in a non-autonomous, discrete nonlinear Schr{\"o}dinger equation setting. The principal motivation for our study stems from the dynamics of Bose-Einstein condensates trapped in a deep optical lattice. We find that under periodic variations of the heights of the interwell barriers (or equivalently of the scattering length), additionally to the modulational instability, a window of parametric instability becomes available to the system. We explore this instability through multiple-scale analysis and identify it numerically. Its principal dynamical characteristic is that, typically, it develops over much larger times than the modulational instability, a feature that is qualitatively justified by comparison of the corresponding instability growth rates

Epidemiology of interstitial lung diseases in Greece

SummaryIntroductionFew data are available on the epidemiology of interstitial lung diseases (ILDs), especially after the current classification of idiopathic interstitial pneumonias. The aim of this study is to provide data on the epidemiology of ILDs in Greece, under the ATS/ERS international consensus.MethodsDepartments of Pneumonology were contacted and asked to complete a questionnaire for every case of ILD that was alive on 2004 as well as for every new case from 1st January 2004 to 31st December 2004. Questions on the patients' demographic data, the exact diagnosis and the procedures used to establish the diagnosis were included. Centers covering about 60% of the Greek population have been analyzed.ResultsA total of 967 cases have been registered. The estimated prevalence of ILDs is 17.3 cases per 100,000 inhabitants. The estimated annual incidence of ILDs is 4.63 new cases per 100,000 inhabitants. The most frequent disease is sarcoidosis (34.1%), followed in decreasing order by idiopathic pulmonary fibrosis (19.5%), ILD associated with collagen vascular diseases (12.4%), cryptogenic organizing pneumonia (5.3%), histiocytosis (3.8%), and hypersensitivity pneumonitis (2.6%). Unclassified ILD or not otherwise specified accounted for the 8.5% of prevalent cases.ConclusionsThese data suggest that sarcoidosis and idiopathic pulmonary fibrosis are the most frequent ILDs in our population. In comparison with the few previous reports, interesting dissimilarities have been observed

Membrane remodelling triggers maturation of excitation–contraction coupling in 3D-shaped human-induced pluripotent stem cell-derived cardiomyocytes

The prospective use of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) for cardiac regenerative medicine strongly depends on the electro-mechanical properties of these cells, especially regarding the Ca$^{2+}$-dependent excitation–contraction (EC) coupling mechanism. Currently, the immature structural and functional features of hiPSC-CM limit the progression towards clinical applications. Here, we show that a specific microarchitecture is essential for functional maturation of hiPSC-CM. Structural remodelling towards a cuboid cell shape and induction of BIN1, a facilitator of membrane invaginations, lead to transverse (t)-tubule-like structures. This transformation brings two Ca$^{2+}$ channels critical for EC coupling in close proximity, the L-type Ca$^{2+}$ channel at the sarcolemma and the ryanodine receptor at the sarcoplasmic reticulum. Consequently, the Ca$^{2+}$-dependent functional interaction of these channels becomes more efficient, leading to improved spatio-temporal synchronisation of Ca$^{2+}$ transients and higher EC coupling gain. Thus, functional maturation of hiPSC-cardiomyocytes by optimised cell microarchitecture needs to be considered for future cardiac regenerative approaches