Biomechanical Study Using the Finite Element Method of Internal Fixation in Pauwels Type III Vertical Femoral Neck Fractures

Background: Several factors are known to influence osseous union of femoral neck fractures. Numerous clinical studies have reported different results, hence with different recommendations regarding treatment of Pauwels III fractures: femoral neck fractures with a more vertically oriented fracture line. The current study aimed to analyze biomechanically whether this fracture poses a higher risk of nonunion. Objectives: To analyze the influence of one designated factor, authors believe that a computerized fracture model, using a finite element Finite Element Method (FEM), may be essential to negate the influence of other factors. The current study aimed to investigate a single factor, i.e. orientation of the fracture line toward a horizontal line, represented by Pauwels classification. It was hypothesized that a model with a vertically oriented fracture line maintaining parity of all other related factors has a higher stress at the fracture site, which would delay fracture healing. This result can be applicable to other types of pinning. Patients and Methods: The finite element models were constructed from computed tomography data of the femur. Three fracture models, treated with pinning, were constructed based on Pauwels classification: Type I, 30° between the fracture line and a horizontal line; Type II, 50°; and Type III, 70°. All other factors were matched between the models. The Von Mises stress and principal stress distribution were examined along with the fracture line in each model. Results: The peak Von Mises stresses at the medial femoral neck of the fracture site were 35, 50 and 130 MPa in Pauwels type I, II, and III fractures, respectively. Additionally, the peak Von Mises stresses along with the fracture site at the lateral femoral neck were 140, 16, and 8 MPa in Pauwels type I, II, and III fractures, respectively. The principal stress on the medial femoral neck in Pauwels type III fracture was identified as a traction stress, whereas the principal stress on the lateral femoral neck in Pauwels type I fracture was a compression stress. Conclusions: The most relevant finding was that hook pinning in Pauwels type III fracture may result in delayed union or nonunion due to significantly increased stress of a traction force at the fracture site that works to displace the fracture. However, in a Pauwels type I fracture, increased compression stress contributes to stabilize it. Surgeons are recommended not to treat Pauwels type III femoral neck fractures by pinning

Interstellar Extinction Law in the J, H, and Ks Bands toward the Galactic Center

We have determined the ratios of total to selective extinction in the near-infrared bands (J, H, Ks) toward the Galactic center from the observations of the region |l| < 2.0deg and 0.5deg < |b| < 1.0deg with the IRSF telescope and the SIRIUS camera. Using the positions of red clump stars in color-magnitude diagrams as a tracer of the extinction and reddening, we determine the average of the ratios of total to selective extinction to be A(Ks)/E(H-Ks) = 1.44+-0.01, A(Ks)/E(J-Ks) = 0.494+-0.006, and A(H)/E(J-H) = 1.42+-0.02, which are significantly smaller than those obtained in previous studies. From these ratios, we estimate that A(J) : A(H) : A(Ks) = 1 : 0.573+-0.009 : 0.331+-0.004 and E(J-H)/E(H-Ks) = 1.72+-0.04, and we find that the power law A(lambda) \propto lambda^{-1.99+-0.02} is a good approximation over these wavelengths. Moreover, we find a small variation in A(Ks)/E(H-Ks) across our survey. This suggests that the infrared extinction law changes from one line of sight to another, and the so-called ``universality'' does not necessarily hold in the infrared wavelengths.Comment: 18 pages, 9 figures, Accepted for publication in the Ap

Universality of electron accumulation at wurtzite c- and a-plane and zinc-blende InN surfaces

Electron accumulation is found to occur at the surface of wurtzite (112¯0), (0001), and (0001¯) and zinc-blende (001) InN using x-ray photoemission spectroscopy. The accumulation is shown to be a universal feature of InN surfaces. This is due to the low Г-point conduction band minimum lying significantly below the charge neutrality level

On multigraded generalizations of Kirillov-Reshetikhin modules

We study the category of Z^l-graded modules with finite-dimensional graded pieces for certain Z+^l-graded Lie algebras. We also consider certain Serre subcategories with finitely many isomorphism classes of simple objects. We construct projective resolutions for the simple modules in these categories and compute the Ext groups between simple modules. We show that the projective covers of the simple modules in these Serre subcategories can be regarded as multigraded generalizations of Kirillov-Reshetikhin modules and give a recursive formula for computing their graded characters

Two-Dimensional Vanadium Carbide (MXene) as Positive Electrode for Sodium-Ion Capacitors

Ion capacitors store energy through intercalation of cations into an electrode at a faster rate than in batteries and within a larger potential window. These devices reach a higher energy density compared to electrochemical double layer capacitor. Li-ion capacitors are already produced commercially, but the development of Na-ion capacitors is hindered by lack of materials that would allow fast intercalation of Na-ions. Here we investigated the electrochemical behavior of 2D vanadium carbide, V2C, from the MXene family. We investigated the mechanism of Na intercalation by XRD and achieved capacitance of ∼100 F/g at 0.2 mV/s. We assembled a full cell with hard carbon as negative electrode, a known anode material for Na ion batteries, and achieved capacity of 50 mAh/g with a maximum cell voltage of 3.5 V

Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is a genetic disorder caused by a deletion of the survival motor neuron 1 gene leading to motor neuron loss, muscle atrophy, paralysis, and death. We show here that induced pluripotent stem cell (iPSC) lines generated from two Type I SMA subjects–one produced with lentiviral constructs and the second using a virus-free plasmid–based approach–recapitulate the disease phenotype and generate significantly fewer motor neurons at later developmental time periods in culture compared to two separate control subject iPSC lines. During motor neuron development, both SMA lines showed an increase in Fas ligand-mediated apoptosis and increased caspase-8 and-3 activation. Importantly, this could be mitigated by addition of either a Fas blocking antibody or a caspase-3 inhibitor. Together, these data further validate this human stem cell model of SMA, suggesting that specific inhibitors of apoptotic pathways may be beneficial for patients