The tantalum-cased tantalum capacitor

Tantalum-cased tantalum capacitors were tested with regard to temperature stability, capacitance ratio, surge current capabilities, shock, vibration, and thermal shock. They were found to be superior to the conventional wet slug tantalum capacitor cased in silver, since they are more resistant to sulfuric acid. The tantalum-cased tantalum capacitors are widely accepted for use in critical electronic equipment because of their excellent performance and reliability

Air data measurement system for space shuttle

It is concluded that air data measurements of angle of attack and sideslip are needed to control the space shuttle vehicles. The basis for this conclusion, along with recommended sensor design and implementation, are described

Computer education : Ireland : a case study

The research described in this thesis is born mainly of the author's experience within the Executive Committee of the Computer Education Society of Ireland (CESI) in trying to get computing onto the curriculum of Irish Second level schools...(continues). The thesis concludes by formulating general guidelines as to why Information Technology should be introduced into the Schools Curriculum. The author insists that, only under the terms of a National Plan and adequate funding can Computer Education, or, in its wider sense, Information Technology, become a viable proposition in Irish schools. A number of recommendations are made and some areas of further research are indicated

A self-consistent ground-state formulation of the first-principles Hubbard U parameter validated on one-electron self-interaction error

In electronic structure methods based on the correction of approximate density-functional theory (DFT) for systematic inaccuracies, Hubbard $U$ parameters may be used to quantify and amend the self-interaction errors ascribed to selected subspaces. Here, in order to enable the accurate, computationally convenient calculation of $U$ by means of DFT algorithms that locate the ground-state by direct total-energy minimization, we introduce a reformulation of the successful linear-response method for $U$ in terms of the fully-relaxed constrained ground-state density. Defining $U$ as an implicit functional of the ground-state density implies the comparability of DFT + Hubbard $U$ (DFT+$U$) total-energies, and related properties, as external parameters such as ionic positions are varied together with their corresponding first-principles $U$ values. Our approach provides a framework in which to address the partially unresolved question of self-consistency over $U$, for which plausible schemes have been proposed, and to precisely define the energy associated with subspace many-body self-interaction error. We demonstrate that DFT+$U$ precisely corrects the total energy for self-interaction error under ideal conditions, but only if a simple self-consistency condition is applied. Such parameters also promote to first-principles a recently proposed DFT+$U$ based method for enforcing Koopmans' theorem

Inapplicability of exact constraints and a minimal two-parameter generalization to the DFT plus U based correction of self-interaction error

In approximate density functional theory (DFT), the self-interaction error is an electron delocalization anomaly associated with underestimated insulating gaps. It exhibits a predominantly quadratic energy-density curve that is amenable to correction using efficient, constraint-resembling methods such as DFT + Hubbard $U$ (DFT+$U$). Constrained DFT (cDFT) enforces conditions on DFT exactly, by means of self-consistently optimized Lagrange multipliers, and while its use to automate error corrections is a compelling possibility, we show that it is limited by a fundamental incompatibility with constraints beyond linear order. We circumvent this problem by utilizing separate linear and quadratic correction terms, which may be interpreted either as distinct constraints, each with its own Hubbard $U$ type Lagrange multiplier, or as the components of a generalized DFT+$U$ functional. The latter approach prevails in our tests on a model one-electron system, $H_2^+$, in that it readily recovers the exact total-energy while symmetry-preserving pure constraints fail to do so. The generalized DFT+$U$ functional moreover enables the simultaneous correction of the total-energy and ionization potential or the correction of either together with the enforcement of Koopmans condition. For the latter case, we outline a practical, approximate scheme by which the required pair of Hubbard parameters, denoted as U1 and U2, may be calculated from first-principles.Comment: 7 pages, 5 figures. Accepted for Physical Review B Rapid Communications on 30th November 201

Why is the Weyl double copy local in position space?

The double copy relates momentum-space scattering amplitudes in gauge and gravity theories. It has also been extended to classical solutions, where in some cases an exact double copy can be formulated directly in terms of products of fields in position space. This is seemingly at odds with the momentum-space origins of the double copy, and the question of why exact double copies are possible in position space and when this form will break has remained largely unanswered. In this paper, we provide an answer to this question, using a recently developed twistorial formulation of the double copy. We show that for certain vacuum type-D solutions, the momentum-space, twistor-space and position-space double copies amount to the same thing, and are directly related by integral transforms. Locality in position space is ultimately a consequence of the very special form of momentum-space three-point amplitudes, and we thus confirm suspicions that local position-space double copies are possible only for highly algebraically-special spacetimes.Comment: 23 pages plus references, 5 figure

Engineering New Approaches to Cancer Vaccines

available in PMC 2016 August 01Recently, a number of promising approaches have been developed using synthetic chemistry, materials science, and bioengineering-based strategies to address challenges in the design of more effective cancer vaccines. At the stage of initial priming, potency can be improved by maximizing vaccine delivery to lymph nodes. Because lymphatic uptake from peripheral tissues is strongly size dependent, antigens and adjuvants packaged into optimally sized nanoparticles access the lymph node with much greater efficiency than unformulated vaccines. Once primed, T cells must home to the tumor site. Because T cells acquire the necessary surface receptors in the local lymph node draining the tissue of interest, vaccines must be engineered that reach organs, such as the lung and gut, which are common sites of tumor lesions but inaccessible by traditional vaccination routes. Particulate vaccine carriers can improve antigen exposure in these organs, resulting in greater lymphocyte priming. Immunomodulatory agents can also be injected directly into the tumor site to stimulate a systemic response capable of clearing even distal lesions; materials have been designed that entrap or slowly release immunomodulators at the tumor site, reducing systemic exposure and improving therapeutic efficacy. Finally, lessons learned from the design of biomaterial-based scaffolds in regenerative medicine have led to the development of implantable vaccines that recruit and activate antigen-presenting cells to drive antitumor immunity. Overall, these engineering strategies represent an expanding toolkit to create safe and effective cancer vaccines.United States. National Institutes of Health (CA174795)United States. National Institutes of Health (CA172164

IL2 targeted to CD8+ T Cells promotes robust effector T-cell responses and potent antitumor immunity

IL2 signals pleiotropically on diverse cell types, some of which contribute to therapeutic activity against tumors, whereas others drive undesired activity, such as immunosuppression or toxicity. We explored the theory that targeting of IL2 to CD8+ T cells, which are key antitumor effectors, could enhance its therapeutic index. To this aim, we developed AB248, a CD8 cis-targeted IL2 that demonstrates over 500-fold preference for CD8+ T cells over natural killer and regulatory T cells (Tregs), which may contribute to toxicity and immunosuppression, respectively. AB248 recapitulated IL2\u27s effects on CD8+ T cells in vitro and induced selective expansion of CD8+T cells in primates. In mice, an AB248 surrogate demonstrated superior antitumor activity and enhanced tolerability as compared with an untargeted IL2Rβγ agonist. Efficacy was associated with the expansion and phenotypic enhancement of tumor-infiltrating CD8+ T cells, including the emergence of a better effector population. These data support the potential utility of AB248 in clinical settings. Significance: The full potential of IL2 therapy remains to be unlocked. We demonstrate that toxicity can be decoupled from antitumor activity in preclinical models by limiting IL2 signaling to CD8+ T cells, supporting the development of CD8+ T cell-selective IL2 for the treatment of cancer. See related article by Kaptein et al. p. 1226

JPART Virtual Issue on Citizen-State Interactions in Public Administration Research

This is the author accepted manuscript. The final version is available from Oxford University Press via the DOi in this recordIn this virtual issue, we bring together a collection of research articles that-although not usually grouped together-all illustrate the importance of citizen-state interactions. Specifically, we include articles that directly incorporate citizens' perceptions, attitudes, experiences of, or behavior related to public administration. About 10% of all JPART articles over the life of the journal so far (1991-2015) met our inclusion criteria. Of those articles, we selected seven for this virtual issue on the basis that they have offered important insights into citizen-state interaction at different stages of the policy cycle. We argue that public administration scholarship should focus much more on the role of citizens and citizen-state interactions at all stages of the policy cycle. This research should focus both on the different forms of interaction citizens have with administrators, and the outcomes of these interactions, for bureaucracy and for citizens themselves