"Ashkui" Vernal Ice-cover Phenomena and Their Ecological Role in Southern Labrador

This is the first documented incident of River Otter (Lutra canadensis) feeding on Common Goldeneye (Bucephala clangula) in a little studied region, southern Labrador. Our observations were made during spring staging when waterfowl aggregate at open water sites in frozen lakes and rivers, locally known as ashkui. We suggest that otters and raptors opportunistically forage on staging waterfowl at ashkui

Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression

background: There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome. We have previously demonstrated that in prostate cancer cell lines PDE4D7 is downregulated in advanced cases of the disease. To investigate further the prognostic power of PDE4D7 expression during prostate cancer progression and assess how downregulation of this PDE isoform may affect disease outcome, we have examined PDE4D7 expression in physiologically relevant primary human samples. methods: About 1405 patient samples across 8 publically available qPCR, Affymetrix Exon 1.0 ST arrays and RNA sequencing data sets were screened for PDE4D7 expression. The TMPRSS2-ERG gene rearrangement status of patient samples was determined by transformation of the exon array and RNA seq expression data to robust z-scores followed by the application of a threshold >3 to define a positive TMPRSS2-ERG gene fusion event in a tumour sample. results: We demonstrate that PDE4D7 expression positively correlates with primary tumour development. We also show a positive association with the highly prostate cancer-specific gene rearrangement between TMPRSS2 and the ETS transcription factor family member ERG. In addition, we find that in primary TMPRSS2-ERG-positive tumours PDE4D7 expression is significantly positively correlated with low-grade disease and a reduced likelihood of progression after primary treatment. Conversely, PDE4D7 transcript levels become significantly decreased in castration resistant prostate cancer (CRPC). conclusions: We further characterise and add physiological relevance to PDE4D7 as a novel marker that is associated with the development and progression of prostate tumours. We propose that the assessment of PDE4D7 levels may provide a novel, independent predictor of post-surgical disease progression

Impact of spin-orbit coupling on the Holstein polaron

We utilize an exact variational numerical procedure to calculate the ground state properties of a polaron in the presence of a Rashba-like spin orbit interaction. Our results corroborate with previous work performed with the Momentum Average approximation and with weak coupling perturbation theory. We find that spin orbit coupling increases the effective mass in the regime with weak electron phonon coupling, and decreases the effective mass in the intermediate and strong electron phonon coupling regime. Analytical strong coupling perturbation theory results confirm our numerical results in the small polaron regime. A large amount of spin orbit coupling can lead to a significant lowering of the polaron effective mass.Comment: 10 pages, 7 figure

Dynamic and static properties of the invaded cluster algorithm

Simulations of the two-dimensional Ising and 3-state Potts models at their critical points are performed using the invaded cluster (IC) algorithm. It is argued that observables measured on a sub-lattice of size l should exhibit a crossover to Swendsen-Wang (SW) behavior for l sufficiently less than the lattice size L, and a scaling form is proposed to describe the crossover phenomenon. It is found that the energy autocorrelation time tau(l,L) for an l*l sub-lattice attains a maximum in the crossover region, and a dynamic exponent z for the IC algorithm is defined according to tau_max ~ L^z. Simulation results for the 3-state model yield z=.346(.002) which is smaller than values of the dynamic exponent found for the SW and Wolff algorithms and also less than the Li-Sokal bound. The results are less conclusive for the Ising model, but it appears that z<.21 and possibly that tau_max ~ log L so that z=0 -- similar to previous results for the SW and Wolff algorithms.Comment: 21 pages with 12 figure