979 research outputs found
An atomic clock with instability
Atomic clocks have been transformational in science and technology, leading
to innovations such as global positioning, advanced communications, and tests
of fundamental constant variation. Next-generation optical atomic clocks can
extend the capability of these timekeepers, where researchers have long aspired
toward measurement precision at 1 part in . This milestone will
enable a second revolution of new timing applications such as relativistic
geodesy, enhanced Earth- and space-based navigation and telescopy, and new
tests on physics beyond the Standard Model. Here, we describe the development
and operation of two optical lattice clocks, both utilizing spin-polarized,
ultracold atomic ytterbium. A measurement comparing these systems demonstrates
an unprecedented atomic clock instability of after
only hours of averaging
Case Report: Color as a Therapeutic Intervention
Peer reviewedFinal Accepted Versio
New classes of exact solutions of three-dimensional Navier-Stokes equations
New classes of exact solutions of the three-dimensional unsteady
Navier-Stokes equations containing arbitrary functions and parameters are
described. Various periodic and other solutions, which are expressed through
elementary functions are obtained. The general physical interpretation and
classification of solutions is given.Comment: 11 page
Hyperpolarizability and operational magic wavelength in an optical lattice clock
Optical clocks benefit from tight atomic confinement enabling extended
interrogation times as well as Doppler- and recoil-free operation. However,
these benefits come at the cost of frequency shifts that, if not properly
controlled, may degrade clock accuracy. Numerous theoretical studies have
predicted optical lattice clock frequency shifts that scale nonlinearly with
trap depth. To experimentally observe and constrain these shifts in an
Yb optical lattice clock, we construct a lattice enhancement cavity
that exaggerates the light shifts. We observe an atomic temperature that is
proportional to the optical trap depth, fundamentally altering the scaling of
trap-induced light shifts and simplifying their parametrization. We identify an
"operational" magic wavelength where frequency shifts are insensitive to
changes in trap depth. These measurements and scaling analysis constitute an
essential systematic characterization for clock operation at the
level and beyond.Comment: 5 + 2 pages, 3 figures, added supplementa
Making optical atomic clocks more stable with level laser stabilization
The superb precision of an atomic clock is derived from its stability. Atomic
clocks based on optical (rather than microwave) frequencies are attractive
because of their potential for high stability, which scales with operational
frequency. Nevertheless, optical clocks have not yet realized this vast
potential, due in large part to limitations of the laser used to excite the
atomic resonance. To address this problem, we demonstrate a cavity-stabilized
laser system with a reduced thermal noise floor, exhibiting a fractional
frequency instability of . We use this laser as a stable
optical source in a Yb optical lattice clock to resolve an ultranarrow 1 Hz
transition linewidth. With the stable laser source and the signal to noise
ratio (S/N) afforded by the Yb optical clock, we dramatically reduce key
stability limitations of the clock, and make measurements consistent with a
clock instability of
An immunotherapy survivor population: health-related quality of life and toxicity in patients with metastatic melanoma treated with immune checkpoint inhibitors
© The Author(s) 2019. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Purpose The immune checkpoint inhibitors (ICIs) have resulted in subgroups of patients with metastatic melanoma achievinghigh-quality durable responses. Metastatic melanoma survivors are a new population in the era of cancer survivorship. The aimofthis study was to evaluate metastatic melanoma survivors in terms of health-related quality of life (HRQoL), immune-relatedadverse events (irAEs) and exposure to immunosuppressive agents in a large single centre in the UK.Methods We defined the survivor population as patients with a diagnosis of metastatic melanoma who achieved a durableresponse to an ICI and had been followed-up for a minimum of 12 months from initiation of ICI without disease progression.HRQoL was assessed using SF-36. Electronic health records were accessed to collect data on demographics, treatments, irAEsand survival. HRQoL data was compared with two norm-based datasets.Results Eighty-four metastatic melanoma survivors were eligible and 87% (N = 73) completed the SF-36. ICI-related toxicity ofany grade occurred in 92%of patients and 43%had experienced a grade 3 or 4 toxicity. Almost half (49%) of the patients requiredsteroids for the treatment of ICI-related toxicity, whilst 14% required treatment with an immunosuppressive agent beyondsteroids.Melanoma survivors had statistically significant lower HRQoL scores with regard to physical, social and physical rolefunctioning and general health compared with the normative population. There was a trend towards inferior scores in patientswith previous exposure to ipilimumab compared with those never exposed to ipilimumab.Conclusions Our results show that metastatic melanoma survivors have potentially experienced significant ICI-related toxicityand experience significant impairments in specific HRQoL domains. Future service planning is required to meet this population’sunique survivorship needs.Peer reviewe
Rabi Spectroscopy and Excitation Inhomogeneity in a 1D Optical Lattice Clock
We investigate the influence of atomic motion on precision Rabi spectroscopy
of ultracold fermionic atoms confined in a deep, one dimensional (1D) optical
lattice. We analyze the spectral components of longitudinal sideband spectra
and present a model to extract information about the transverse motion and
sample temperature from their structure. Rabi spectroscopy of the clock
transition itself is also influenced by atomic motion in the weakly confined
transverse directions of the optical lattice. By deriving Rabi flopping and
Rabi lineshapes of the carrier transition, we obtain a model to quantify trap
state dependent excitation inhomogeneities. The inhomogeneously excited
ultracold fermions become distinguishable, which allows s-wave collisions. We
derive a detailed model of this process and explain observed density shift data
in terms of a dynamic mean field shift of the clock transition.Comment: 11 pages, 8 figures, to appear in Phys. Rev. A. Changes to abstract,
text, and figures, new referenc
- …