Capability in the digital: institutional media management and its dis/contents

This paper explores how social media spaces are occupied, utilized and negotiated by the British Military in relation to the Ministry of Defence’s concerns and conceptualizations of risk. It draws on data from the DUN Project to investigate the content and form of social media about defence through the lens of ‘capability’, a term that captures and describes the meaning behind multiple representations of the military institution. But ‘capability’ is also a term that we hijack and extend here, not only in relation to the dominant presence of ‘capability’ as a representational trope and the extent to which it is revealing of a particular management of social media spaces, but also in relation to what our research reveals for the wider digital media landscape and ‘capable’ digital methods. What emerges from our analysis is the existence of powerful, successful and critically long-standing media and reputation management strategies occurring within the techno-economic online structures where the exercising of ‘control’ over the individual – as opposed to the technology – is highly effective. These findings raise critical questions regarding the extent to which ‘control’ and management of social media – both within and beyond the defence sector – may be determined as much by cultural, social, institutional and political influence and infrastructure as the technological economies. At a key moment in social media analysis, then, when attention is turning to the affordances, criticisms and possibilities of data, our research is a pertinent reminder that we should not forget the active management of content that is being similarly, if not equally, effective

Highgate Cemetery heterotopia: A Creative Counterpublic Space

Highgate Cemetery is nominally presented as a heterotopia, constructed, and theorized through the articulation of three “spaces.” First, it is configured as a public space which organizes the individual and the social, where the management of death creates a relationship between external space and its internal conceptualization. This reveals, enables, and disturbs the sociocultural and political imagination which helps order and disrupt thinking. Second, it is conceived as a creative space where cemetery texts emplace and materialize memory that mirrors the cultural capital of those interred, part of an urban aesthetic which articulates the distinction of the metropolitan elite. Last, it is a celebritized counterpublic space that expresses dissent, testimony to those who have actively imagined a better world, which is epitomized by the Marx Memorial. Representation of the cemetery is ambiguous as it is recuperated and framed by the living with the three different “spaces” offering heterotopic alliances

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Genetic mechanisms of critical illness in COVID-19.

Host-mediated lung inflammation is present1, and drives mortality2, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development3. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10-8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10-8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10-12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on chromosome 21q22.1 (rs2236757, P = 4.99 × 10-8) in the interferon receptor gene IFNAR2. We identified potential targets for repurposing of licensed medications: using Mendelian randomization, we found evidence that low expression of IFNAR2, or high expression of TYK2, are associated with life-threatening disease; and transcriptome-wide association in lung tissue revealed that high expression of the monocyte-macrophage chemotactic receptor CCR2 is associated with severe COVID-19. Our results identify robust genetic signals relating to key host antiviral defence mechanisms and mediators of inflammatory organ damage in COVID-19. Both mechanisms may be amenable to targeted treatment with existing drugs. However, large-scale randomized clinical trials will be essential before any change to clinical practice

Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity

The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 severity. First, variants were converted into separate sets of Boolean features, depending on the absence or the presence of variants in each gene. An ensemble of LASSO logistic regression models was used to identify the most informative Boolean features with respect to the genetic bases of severity. The Boolean features selected by these logistic models were combined into an Integrated PolyGenic Score that offers a synthetic and interpretable index for describing the contribution of host genetics in COVID-19 severity, as demonstrated through testing in several independent cohorts. Selected features belong to ultra-rare, rare, low-frequency, and common variants, including those in linkage disequilibrium with known GWAS loci. Noteworthily, around one quarter of the selected genes are sex-specific. Pathway analysis of the selected genes associated with COVID-19 severity reflected the multi-organ nature of the disease. The proposed model might provide useful information for developing diagnostics and therapeutics, while also being able to guide bedside disease management. © 2021, The Author(s)

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Higher energy-efficiency, readily transportable incubators

Transport incubators are devices used to house and protect premature or small babies individually during journeys between home and hospital or between hospitals, often in circumstances where the maintenance of comfortable environmental conditions within the incubators is essential for the survival of the infants. During use, the transport incubator has to frequently rely for its energy supply solely upon the storage capacity of a [`]built-in' electric battery, which is the principal inhibiting factor limiting the available performance and duration of operation. During the present study of the environmental and engineering factors which affect the performances of such transport incubators, carried out for Air-Shields Vickers plc, consideration has been given to the use of two technologies to seek to improve both the quality of the artificially created internal environment in the incubator and the duration of operation independent of external electricity supplies. In particular, consideration has focused upon two possibilities:1. 1. The use of a thermoelectric heat-pump (a) as a substitute for the conventional resistance heater within the incubator, so that the utilisation of the existing electric-battery charge would thereby be enhanced; and (b) to provide active refrigeration within the incubator without incurring the problems of noise and vibration normally associated with the presence of a compressor refrigerator.2. 2. The potential for stored thermal energy to augment the energy-storage capacity of the electric battery. It has been shown that the use of a thermoelectric heat-pump can approximately triple the duration of use per electric-battery charge, as well as provide refrigeration cooling without incurring a significant weight penalty. The cost of the thermoelectric heat-pump is less than the additional expense incurred for the larger battery, which would otherwise be necessary to achieve the required operational duration. Also weight penalties would be involved in the use of a larger battery. Employing a supplementary thermal-store has been shown to be feasible and desirable, so that any heat lost during the permitted short-period, intermittent access to the incubator under adverse weather conditions can be [`]made good' rapidly. This requires a very high but transient supply of heat.

Cheap effective thermal solar-energy collectors

A light-weight flexible solar-collector, with a wavelength-selective absorption surface and an insolation-transparent thermal-insulation protector for its aperture, was built and tested. Its cheapness and high performance, relative to a conventional flat-plate solar-collector, provide a prima-facie case for the more widespread adoption of its design.

Heat transfers through mechanically-stimulated particle beds

A particle bed can be effectively [`]fluidised' by means of a vibrating diaphragm. Such beds of vibrating particles (whether in nominally-still air or even in a vacuum) exhibit high thermal-conductances, which are comparable with those of air-fludised beds. The mechanically-stimulated beds have potential applications as thermal switches.