[Unusual association between auto-immune hepatitis and pyoderma gangrenosum. A case report].

Pyoderma gangrenosum is an uncommon neutrophilic dermatosis that presents as an inflammatory and ulcerative disorder of the skin. This entity is associated with systemic diseases and autoimmune diseases but exceptionally with autoimmune hepatitis. We report the case of a 40 year-old woman diagnosed with type 1 autoimmune hepatitis 12 years earlier and admitted for the appearance of an ulcerative lesion in the left leg. Histology confirmed pyoderma gangrenosum.Le Pyoderma gangrenosum (PG) est une affection rare appartenant au groupe des dermatoses neutrophiliques. Cette entité est associée à l’existence de maladies systémiques et autoimmunes, mais exceptionnellement à une hépatite auto-immune. Nous rapportons l’observation d’une patiente âgée de 40 ans atteinte d’une hépatite auto-immune (HAI) de type 1 depuis 12 ans admise pour une lésion ulcéreuse du membre inférieur gauche. L’histologie confirmera l’existence d’un pyoderma gangrenosum

[Unusual association between auto-immune hepatitis and pyoderma gangrenosum. A case report].

Pyoderma gangrenosum is an uncommon neutrophilic dermatosis that presents as an inflammatory and ulcerative disorder of the skin. This entity is associated with systemic diseases and autoimmune diseases but exceptionally with autoimmune hepatitis. We report the case of a 40 year-old woman diagnosed with type 1 autoimmune hepatitis 12 years earlier and admitted for the appearance of an ulcerative lesion in the left leg. Histology confirmed pyoderma gangrenosum

Case Report Pseudopheochromocytoma Associated with Domestic Assault

Pseudopheochromocytoma has a clinical presentation that is similar to pheochromocytoma. It manifests itself with paroxysmal hypertension crises, associated with various symptoms such as headaches, chest pain, nausea, palpitations, and dizziness. Patients are usually asymptomatic in between the crises. Unlike pheochromocytoma, there is no catecholamines overproduction in this pathology: hypertensive peaks are caused by a hyperactivation of the sympathetic nervous system, which is often triggered by a psychological trauma in the past. Treatment of pseudopheochromocytoma can be challenging due to normal blood pressure values in between the hypertensive peaks; it includes alpha-and beta-blockers for moderate crises and prevention and must be combined with psychopharmacologic agents such as anxiolytics or antidepressant drugs. Psychotherapy and dietetic treatment are also crucial in pseudopheochromocytoma management

Jupiter ICY moon explorer (JUICE): Advances in the design of the radar for Icy Moons (RIME)

This paper presents the Radar for Icy Moon Exploration (RIME) that is a fundamental payload in the Jupiter Icy Moon Explorer (JUICE) mission of the European Space Agency (ESA). RIME is a radar sounder aimed to study the subsurface of Jupiter's icy moons Ganymede, Europa and Callisto. The paper illustrates the main goals of RIME, its architecture and parameters and some recent advances in its design

The Radar For Icy Moon Exploration (RIME) On The Juice Mission

The Radar for Icy Moon Exploration (RIME) is one of the main instruments included in the JUpiter ICy moons Explorer (JUICE) ESA mission. It is a radar sounder designed for studying the subsurface geology and geophysics of Galilean icy moons (i.e., Ganymede, Europa and Callisto) and for detecting possible subsurface water. RIME is designed for penetration of the icy moons up to a depth of 9 km. Two main operation scenarios are foreseen for RIME: i) flyby observations of Europa, Ganymede and Callisto (from a distance of 1000 km to the closest approach of about 400 km); and ii) circular orbital observations around Ganymede at 500 km of altitude. According to these scenarios, RIME is designed to explore the icy shell of the Galilean icy satellites by characterizing the wide range of compositional, thermal, and structural variation found in the subsurface of these moons. RIME observations will profile the ice shells of the Galilean icy satellites with specific focus on Ganymede given the circular orbital phase. The acquired measures will provide geological context on hemispheric (thousands of km), regional (hundreds of km with multiple overlaps), and targeted (tens of km) scales appropriate for a variety of hypothesis tests. RIME will operate in a single frequency band, centred at 9 MHz. The frequency was selected as the result of extensive study of penetration capabilities, surface roughness of the moons, Jovian radio noise, antenna accommodation, and system design. The 9 MHz frequency provides penetration capabilities and mitigation of surface scattering (which can cause signal loss and clutter issues), at the expense of mapping coverage, as it is likely to obtain high SNR observations only on the anti-Jovian side of the target moons. The RIME antenna is a 16 m dipole. The chirp pulse bandwidth is up to 3 MHz, which provides vertical resolution of about 50 m in ice after side lobe weighting. RIME will also operate with 1 MHz bandwidth to reduce data volume when observing deep sounding targets. This corresponds to a vertical resolution of about 140 m in ice. Within the high and low resolution modes, parameters can be adjusted to change the output data rate. RIME can downlink raw data for on-ground focusing or pre-processed data by a presuming operation for data rate reduction