Content of primary and secondary products of lipid peroxidation in loach embryos under the effect of flurenizyd

The effect of flurenizide (antibiotic of antimicrobial, antituberculousis, antichlamy­dia, immunomodulator, antioxidant, hepatoprotective, antiinflammatory, antiviral action) on the intensity of lipid peroxidation processes of embryos Misgurnus fossilis L. at the stage of 2, 16, 64, 256 and 1024 blastomeres was investigated. Flurenizide in all studied concentrations (0.01; 0.05; 0.15; 1; 5; 15 mM) caused increase in content of lipid peroxidation primary products (hydroperoxides) during development of embryos but decrease on stage 256 blastomeres. The content of secondary products of lipid peroxidation (TBA-positive products) increased during the development of embryos under the effect of antibiotic in concentration of 0.01÷1 mM, and decreased at the concentration 15 mM. It was found that loach embryos were the most sensitive to flurenizide at the stage of 16 blastomeres when the content of hydroperoxides is the maximum. The less sensitive stage of development of germ cells to the exogenous factors was 256 blastomeres