The idiosyncratic drug-induced gene expression changes in HepG2 cells

The inflammatory stress has been associated with an increase in susceptibility to idiosyncratic drug-induced liver injury (DILI). However, the molecular mechanisms of this inflammation-associated idiosyncratic drug hepatotoxicity remain unknown. We exposed HepG2 cells with high and low doses of three idiosyncratic (I) and three non-idiosyncratic (N) compounds, in the presence (I+ and N+) or absence (I- and N-) of a cytokine mix for 6, 12 and 24 h. To investigate the genome-wide expression patterns, microarray was performed using the Agilent 4×44K Whole Human Genome chips. The data presented in this DIB include the expression of genes participating in the ceramide metabolism, ER stress, apoptosis and cell survival pathways. The functions of these genes were illustrated in our associated article (Jiang et al., 2017) [1]. Raw and normalized gene expression data are available through NCBI GEO (accession number GSE102006)

SUPPLEMENTS Test of interaction models with the KASCADE hadron calorimeter

The interpretation of extensive air shower measurements often requires the comparison with EAS simulations. These calculations rely on hadronic interaction models which have to extrapolate into kinematical and energy regions not covered by present-day collider experiments. The KASCADE experiment with its large hadron calorimeter and its detectors for the electromagnetic and muonic components provides experimental data to check hadronic interaction models. For the EAS simulations the program CORSIKA with several hadronic event generators embedded is used. Different hadronic observables are investigated as well as their correlations with the electromagnetic and muonic components. Comparing the interaction models QGSJET 98, NEXUS II, and DPMJET 11.5, it is found, that QGSJET describes the data best. 1

www.elsevier.tiocate/npe Towards the Energy Spectrum and Composition of Primary Cosmic Rays in the Knee Region: Methods and Results at KASCADE

KASCADE (KArlsruhe Shower Core and Array DEtector) is a multi-detector setup to observe the electro-magnetic, muonic and hadronic air shower components simultaneously at primary energies in the region of the “knee”. A large number of observables per single shower are registered. The main aims of the experiment are the determination of the primary energy spectrum around the “knee ” and the energy variation of the chemical composition. The measurements reveal an increasing mean mass of the primary cosmic rays above the observed kink, and a sharper knee for the light primary component than for the all-particle spectrum, and the absence of a knee for the heavy component between 1 and 10 PeV. 1