1,970 research outputs found
Sub-structural Niching in Estimation of Distribution Algorithms
We propose a sub-structural niching method that fully exploits the problem
decomposition capability of linkage-learning methods such as the estimation of
distribution algorithms and concentrate on maintaining diversity at the
sub-structural level. The proposed method consists of three key components: (1)
Problem decomposition and sub-structure identification, (2) sub-structure
fitness estimation, and (3) sub-structural niche preservation. The
sub-structural niching method is compared to restricted tournament selection
(RTS)--a niching method used in hierarchical Bayesian optimization
algorithm--with special emphasis on sustained preservation of multiple global
solutions of a class of boundedly-difficult, additively-separable multimodal
problems. The results show that sub-structural niching successfully maintains
multiple global optima over large number of generations and does so with
significantly less population than RTS. Additionally, the market share of each
of the niche is much closer to the expected level in sub-structural niching
when compared to RTS
Quantum Mechanics of Extended Objects
We propose a quantum mechanics of extended objects that accounts for the
finite extent of a particle defined via its Compton wavelength. The Hilbert
space representation theory of such a quantum mechanics is presented and this
representation is used to demonstrate the quantization of spacetime. The
quantum mechanics of extended objects is then applied to two paradigm examples,
namely, the fuzzy (extended object) harmonic oscillator and the Yukawa
potential. In the second example, we theoretically predict the phenomenological
coupling constant of the meson, which mediates the short range and
repulsive nucleon force, as well as the repulsive core radius.Comment: RevTex, 24 pages, 1 eps and 5 ps figures, format change
Deep learning techniques and mathematical modeling allow 3D analysis of mitotic spindle dynamics
Time-lapse microscopy movies have transformed the study of subcellular dynamics. However, manual analysis of movies can introduce bias and variability, obscuring important insights. While automation can overcome such limitations, spatial and temporal discontinuities in time-lapse movies render methods such as 3D object segmentation and tracking difficult. Here, we present SpinX, a framework for reconstructing gaps between successive image frames by combining deep learning and mathematical object modeling. By incorporating expert feedback through selective annotations, SpinX identifies subcellular structures, despite confounding neighbor-cell information, non-uniform illumination, and variable fluorophore marker intensities. The automation and continuity introduced here allows the precise 3D tracking and analysis of spindle movements with respect to the cell cortex for the first time. We demonstrate the utility of SpinX using distinct spindle markers, cell lines, microscopes, and drug treatments. In summary, SpinX provides an exciting opportunity to study spindle dynamics in a sophisticated way, creating a framework for step changes in studies using time-lapse microscopy
Comment on "Quantum mechanics of smeared particles"
In a recent article, Sastry has proposed a quantum mechanics of smeared
particles. We show that the effects induced by the modification of the
Heisenberg algebra, proposed to take into account the delocalization of a
particle defined via its Compton wavelength, are important enough to be
excluded experimentally.Comment: 2 page
Energy landscape of a Lennard-Jones liquid: Statistics of stationary points
Molecular dynamics simulations are used to generate an ensemble of saddles of
the potential energy of a Lennard-Jones liquid. Classifying all extrema by
their potential energy u and number of unstable directions k, a well defined
relation k(u) is revealed. The degree of instability of typical stationary
points vanishes at a threshold potential energy, which lies above the energy of
the lowest glassy minima of the system. The energies of the inherent states, as
obtained by the Stillinger-Weber method, approach the threshold energy at a
temperature close to the mode-coupling transition temperature Tc.Comment: 4 RevTeX pages, 6 eps figures. Revised versio
Thermodynamics and Kinetics of the Carbonyl process for the Refining of Nickel
The discovery by Langer and Mond in 1889 of the reaction of carbon monoxide at atmospheric pressure with active nickel at 315-353K to form gaseous Ni(C0)4 and its ready reversibility at higher temperatures paved the way for the development of the carbonyl refining process for nickel. Subsequently, to improve the kinetics, a high pressure process was developed for the carbonyl refining of Ni at somewhat higher temperatures. The carbonyl process makes it possible to produce nickel of very high purity and extr-emely fine size. This paper describes the thermodynamics and kinetics of the formation of nickel carbonyl from pure nickel and its alloys, its vapour phase transport and its decomposition.. The thermodynamic analysis includes const-ruction of Ellingham diagrams, pressure-temperature rela-tionships, partial pressuretemperature relationships and productivity function-temperature-pressure relationships for the various carbonyls. The kinetics of Ni(CO)4 forma-tion and decomposition has been analyzed based on the information available in the literature
Liquid Limits: The Glass Transition and Liquid-Gas Spinodal Boundaries of Metastable Liquids
The liquid-gas spinodal and the glass transition define ultimate boundaries
beyond which substances cannot exist as (stable or metastable) liquids. The
relation between these limits is analyzed {\it via} computer simulations of a
model liquid. The results obtained indicate that the liquid - gas spinodal and
the glass transition lines intersect at a finite temperature, implying a glass
- gas mechanical instability locus at low temperatures. The glass transition
lines obtained by thermodynamic and dynamic criteria agree very well with each
other.Comment: 5 pages, 4 figures, to appear in Phys. Rev. Let
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