African-American patients with cancer Talking About Clinical Trials (TACT) with oncologists during consultations: evaluating the efficacy of tailored health messages in a randomised controlled trial—the TACT study protocol

Introduction Low rates of accrual of African-American (AA) patients with cancer to therapeutic clinical trials (CTs) represent a serious and modifiable racial disparity in healthcare that impedes the development of promising cancer therapies. Suboptimal physician–patient consultation communication is a barrier to the accrual of patients with cancer of any race, but communication difficulties are compounded with AA patients. Providing tailored health messages (THM) to AA patients and their physician about CTs has the potential to improve communication, lower barriers to accrual and ameliorate health disparities. Objective (1) Demonstrate the efficacy of THM to increase patient activation as measured by direct observation. (2) Demonstrate the efficacy of THM to improve patient outcomes associated with barriers to AA participation. (3) Explore associations among preconsultation levels of: (A) trust in medical researchers, (B) knowledge and attitudes towards CTs, (C) patient-family member congruence in decision-making, and (D) involvement/information preferences, and group assignment. Methods and analysis First, using established methods, we will develop THM materials. Second, the efficacy of the intervention is determined in a 2 by 2 factorial randomised controlled trial to test the effectiveness of (1) providing 357 AA patients with cancer with THM with 2 different ‘depths’ of tailoring and (2) either providing feedback to oncologists about the patients\u27 trial THM or not. The primary analysis compares patient engaged communication in 4 groups preconsultation and postconsultation. Ethics and dissemination This study was approved by the Virginia Commonwealth University Institutional Review Board. To facilitate use of the THM intervention in diverse settings, we will convene ‘user groups’ at 3 major US cancer centres. To facilitate dissemination, we will post all materials and the implementation guide in publicly available locations

A New Measurement of Cosmic Ray Composition at the Knee

The Dual Imaging Cerenkov Experiment (DICE) was designed and operated for making elemental composition measurements of cosmic rays near the knee of the spectrum at several PeV. Here we present the first results using this experiment from the measurement of the average location of the depth of shower maximum, , in the atmosphere as a function of particle energy. The value of near the instrument threshold of ~0.1 PeV is consistent with expectations from previous direct measurements. At higher energies there is little change in composition up to ~5 PeV. Above this energy is deeper than expected for a constant elemental composition implying the overall elemental composition is becoming lighter above the knee region. These results disagree with the idea that cosmic rays should become on average heavier above the knee. Instead they suggest a transition to a qualitatively different population of particles above 5 PeV.Comment: 7 pages, LaTeX, two eps figures, aas2pp4.sty and epsf.sty included, accepted by Ap.J. Let

Les effets prédits et observés du Bulletin des écoles secondaires du Québec

Ce rapport est structuré de la manière suivante : dans un premier temps, nous rappelons les éléments historiques, politiques et institutionnels qui structurent le champ éducatif québécois et rendent possible, tout en l’encadrant, la concurrence entre les établissements; dans un second temps, après avoir rappelé l’origine des classements d’établissements scolaires canadiens, nous analysons le discours de légitimation du Bulletin des écoles québécois en dégageant les effets positifs attendus; dans un troisième temps, nous explicitons notre démarche empirique, la base de données construite, les choix opérés et les analyses effectuées; dans un quatrième temps, nous rapportons et discutons les principaux résultats. En conclusion, nous réfléchissons aux implications de ces résultats au plan des modèles théoriques en débat et des politiques éducatives.Introduction 3; Contexte : Québec, société distincte 6; Les effets attendus de la liberté de choix et de la concurrence entre établissements, informés par le Bulletin des écoles 9; Démarche empirique 14; La construction de la base de données 14; L’analyse au niveau provincial, régional et du grand Montréal 17; Les résultats 18; La situation pour l’ensemble du Québec et de ses régions 18; La situation à Montréal 21; Comparaison des établissements situés au milieu du classement 22; Discussion 24; Conclusion 28; Références 30; Annexes 32

New Limits to the Infrared Background: Bounds on Radiative Neutrino Decay and on Contributions of Very Massive Objects to the Dark Matter Problem

From considering the effect of γ-γ interactions on recently observed TeV gamma-ray spectra, improved limits are set to the density of extragalactic infrared photons which are robust and essentially model independent. The resulting limits are more than an order of magnitude more restrictive than direct observations in the 0.025–0.3 eV regime. These limits are used to improve constraints on radiative neutrino decay in the mass range above 0.05 eV and to rule out very massive objects as providing the dark matter needed to explain galaxy rotation curves. Lower bounds on the maximum distance which TeV gamma rays may probe are also derived

Simultaneous traveling convection vortex events and Pc1 wave bursts at cusp latitudes observed in Arctic Canada and Svalbard

Traveling convection vortices (TCVs), which appear in ground magnetometer records at near‐cusp latitudes as solitary ~5 mHz pulses, are a signature of dynamical processes in the ion foreshock upstream of the Earth's bow shock that can stimulate transient compressions of the dayside magnetosphere. These compressions can also increase the growth rate of electromagnetic ion cyclotron (EMIC) waves, which appear in ground records at these same latitudes as bursts of Pc1 pulsations. In this study we have identified TCVs and simultaneous Pc1 burst events in two regions, Eastern Arctic Canada and Svalbard, using a combination of fluxgate magnetometers and search coil magnetometers in each region. By looking for the presence of TCVs and Pc1 bursts in two different sequences, we have found that the distribution of Pc1 bursts was more tightly clustered near local noon than that of TCV events, that neither TCVs nor Pc1 bursts were always associated with the other, and even when they occurred simultaneously their amplitudes showed little correlation. Magnetometer data from GOES‐12 were also used to characterize the strength of the magnetic compressions at geosynchronous orbit near the magnetic equator. Compressions > 2 nT at GOES‐12 occurred during 57% of the Canadian TCV events, but during ~85% of the simultaneous TCV/Pc1 burst events. There was again little evident correlation between TCV and GOES‐12 compression amplitudes. We have also documented unusually low EMIC wave activity during this deep solar minimum interval, and we attribute the low occurrence percentage of combined events in this study to this minimum. Key Points TCVs and Pc1 bursts often occur together in high‐latitude magnetometer data Pc1 events were more tightly clustered near local noon than TCV events Pc1 activity was unusually low during the solar activity minimum in 2008–2010.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/101826/1/jgra50604.pd

Signatures of stirring and mixing near the Gulf Stream front

In October, 1986 the surface waters adjacent to the Gulf Stream front were surveyed with an undulating profiler to describe the finescale structure of the mixed layer. The profiler was a Seasoar equipped with a CTD and fluorometer. The survey first defined the structure of a cyclonic eddy which resembled frontal eddies of the South Atlantic Bight in sea surface temperature imagery. The Seasoar transects revealed, however, that the cyclonic eddy lacked a cold dome typically seen in frontal eddies. Farther downstream the Seasoar defined the structure of streamers of Gulf Stream and Shelf water wrapped about the southern edge of a warm-core ring. The streamers had lateral and along-axis dimensions on the order of ≈ 10 km and 100 km, respectively, and were bordered by narrow intrusive features. The temporal history of the streamers was described from SST imagery, and the surface flow derived from ship\u27s drift vectors. CTD casts taken while following an isopycnal float provided a means to examine the structure of the intrusive features. Interleaving was evident at the boundaries of the streamers and intrusive features where high conductivity Cox numbers were concentrated, suggesting elevated microstructure activity. The Turner angle distribution, indicating either saltfingering or diffusive convection, did not correlate well with the Cox number distribution. This is interpreted as evidence that lateral, rather than diapycnal, mixing was the process mediating the exchange of properties at the boundaries of contrasting water types. In contrast to physical properties, the distribution of fluorescence showed relatively less structure in the surface layer between the ring and Gulf Stream front. In the surface layers of the two streamers the pigment and bacterial biomass, and the diatom species composition, were typical of Slope water communities. We hypothesize that small-scale mixing processes concentrated at the boundaries of the streamers were the mechanism by which Slope water plankton were seeded into streamers of different hydrographic origins. Presumably, high netplankton growth rates allowed the Slope water species to dominate the communities in the streamers

Multiwavelength Observations of a Flare from Markarian 501

We present multiwavelength observations of the BL Lacertae object Markarian 501 (Mrk 501) in 1997 between April 8 and April 19. Evidence of correlated variability is seen in very high energy (VHE, E > 350 GeV) gamma-ray observations taken with the Whipple Observatory gamma-ray telescope, data from the Oriented Scintillation Spectrometer Experiment of the Compton Gamma-Ray Observatory, and quicklook results from the All-Sky Monitor of the Rossi X-ray Timing Explorer while the Energetic Gamma-Ray Experiment Telescope did not detect Mrk 501. Short term optical correlations are not conclusive but the U-band flux observed with the 1.2m telescope of the Whipple Observatory was 10% higher than in March. The average energy output of Mrk 501 appears to peak in the 2 keV to 100 keV range suggesting an extension of the synchrotron emission to at least 100 keV, the highest observed in a blazar and ~100 times higher than that seen in the other TeV-emitting BL Lac object, Mrk 421. The VHE gamma-ray flux observed during this period is the highest ever detected from this object. The VHE gamma-ray energy output is somewhat lower than the 2-100 keV range but the variability amplitude is larger. The correlations seen here do not require relativistic beaming of the emission unless the VHE spectrum extends to >5 TeV.Comment: 10 pages, 2 figures, accepted for publication in ApJ Letter