Duodenal-type follicular lymphoma： a report of three cases

Duodenal-type follicular lymphoma （D-FL） is a rare disease. At present，biological characteristics and clinical progression of D-FL are still unclear. In this article，three patients with D-FLwere reported，with an average age of 51 years. All patients were diagnosed during physical examination. Two patients had no complaints，and one patient reported upper abdominal discomfort and fatigue.After admission，all patients underwent CT and gastroscopy，and the diagnosis of D-FL was finally confirmed by pathological biopsy. Two patients refused treatment because of no symptoms，and the disease did not progress during follow-up. One patient received R2 regimen （obinutuzumab + lenalidomide） chemotherapy for more than 1 year. Upon the submission date，heoccasionally felt epigastric discomfort，fatigue and night sweats. The diagnosis and treatment of these three patients suggest that biological behaviors of D-FL are constantly indolent. Regular follow-up observation can be considered for asymptomatic patients，and active treatment can be performed for symptomatic young patients if they accept. At present，there is no guideline or consensus on the diagnosis and treatment of D-FL at home and abroad. The diagnosis and treatment process of three patients are reported，aiming to deepen clinicians’ understanding of diagnosis and treatment of D-FL

TARIFA (Cádiz). Estrategia militar. 1840 (1811-1812)

Orientado con lis en rosa de 8 vientosRelieve representado por sombreadoRelación de los principales conventos, baterias, torres y casamatas indicada por clave alfabéticaNota relativa a que "El Sitio comenzó el 11 de diciembre de 1811 y terminó el 4 de enero de 1812

NLTE spectroscopic analysis of the 3^3He anomaly in subluminous B-type stars

Several B-type main-sequence stars show chemical peculiarities. A particularly striking class are the $^3$He stars, which exhibit a remarkable enrichment of $^3$He with respect to $^4$He. This isotopic anomaly has also been found in blue horizontal branch (BHB) and subdwarf B (sdB) stars, which are helium-core burning stars of the extreme horizontal branch. Using a hybrid local/non-local thermodynamic equilibrium (LTE/NLTE) approach for B-type stars, we analyzed high-quality spectra of two known $^3$He BHBs and nine known $^3$He sdBs to determine their isotopic helium abundances and $^4$He/$^3$He abundance ratios. We redetermined their atmospheric parameters and analyzed selected neutral helium lines, including $\lambda$4922 $\mathring{A}$ and $\lambda$6678 $\mathring{A}$, which are very sensitive to $^4$He/$^3$He. Most of the $^3$He sdBs cluster in a narrow temperature strip between 26000 K and 30000 K and are helium deficient in accordance with previous LTE analyses. BD+48$^\circ$ 2721 is reclassified as a BHB star because of its low temperature ($T_{\mathrm{eff}}=$ 20700 K). Whereas $^4$He is almost absent ($^4$He/$^3$He$<$ 0.25) in most of the known $^3$He stars, other sample stars show abundance ratios up to $^4$He/$^3$He$=$2.51. A search for $^3$He stars in the ESO SPY survey led to the discovery of two new $^3$He sdB stars (HE 0929-0424 and HE 1047-0436). The observed helium line profiles of all BHBs and of three sdBs are not matched by chemically homogeneous atmospheres, but hint at vertical helium stratification. This phenomenon has been seen in other peculiar B-type stars, but is found for the first time for sdBs. We estimate helium to increase from the outer to the inner atmosphere by factors ranging from 1.4 (SB 290) up to 8.0 (BD+48$^\circ$ 2721).Comment: 19 pages, 79 figures submitted to Astronomy&Astrophysic

Component Composability Issues in Object-Oriented Programming

Building software from reusable components is considered important in reducing development costs. Object-oriented languages such as C++, Smalltalk and Java, however, are not capable of expressing certain aspects of applications in a composable way. Software engineers may experience difficulties in composing applications from components, for example if components implement code for multiple views, dynamic inheritance and synchronization [Aksit96]. If these aspects have to be programmed, then object-oriented languages may require a considerable amount of redefinition although this may not be intuitively necessary. To solve the composability problems, languages must be enhanced modularly without losing their basic characteristics. In addition, since more than one problem can be experienced for the same object, enhancements must be independent from each other. We have extended the conventional object-oriented model using the concept of composition-filters. Composition-filters can be attached to objects expressed for example in Smalltalk and Java. A number of different filter types have been defined, each addressing a certain concern. This paper first illustrates some practical problems and then introduces composition-filters solutions to overcome these problems

De-Trending Time Series for Astronomical Variability Surveys

We present a de-trending algorithm for the removal of trends in time series. Trends in time series could be caused by various systematic and random noise sources such as cloud passages, changes of airmass, telescope vibration or CCD noise. Those trends undermine the intrinsic signals of stars and should be removed. We determine the trends from subsets of stars that are highly correlated among themselves. These subsets are selected based on a hierarchical tree clustering algorithm. A bottom-up merging algorithm based on the departure from normal distribution in the correlation is developed to identify subsets, which we call clusters. After identification of clusters, we determine a trend per cluster by weighted sum of normalized light-curves. We then use quadratic programming to de-trend all individual light-curves based on these determined trends. Experimental results with synthetic light-curves containing artificial trends and events are presented. Results from other de-trending methods are also compared. The developed algorithm can be applied to time series for trend removal in both narrow and wide field astronomy.Comment: Revised version according to the referee's second revie