New isoquinoline alkaloid from Carduus crispus L.

A new isoquinoline alkaloid, along with other known 4 bioactive compounds (1 isoquinoline alkaloid, 2 flavonoids, 1 coumarin), were isolated from the ethanol extract of aerial parts of Carduus crispus L. Crispine А N-oxide was newly isolated compound, two of them (quercetin and rutin) were compounds isolated for the first time from indicated plant. The structures of these compounds were elucidated and confirmed with spectroscopic methods e.g. 1H-NMR, 13C-NMR, EI-MS, COSY, HSQC, HMBC, and by comparison with literature data.DOI: http://dx.doi.org/10.5564/mjc.v12i0.178 Mongolian Journal of Chemistry Vol.12 2011: 85-8

Hepatoprotective effects of Paeonia anomala against acetaminophen-induced cell damage through activation of anti-oxidant system

Overdose of the analgesic and anti-pyretic acetaminophen causes a potentially fatal hepatic necrosis due to a high toxicity and depletion of cellular defense mechanisms. In the present work, the potential hepatoprotective effect of the fruit extract of Paeonia anomala against acetaminophen induced cell damages was evaluated in cultured HepG2 cells and compared to the root extract. The fruit extract showed a potent protection against acetaminophen induced cell death, while the root extract showed a weak protection. Particularly, the pre-treatment of lower doses of the fruit extract, 10 μg/ mL and 20 μg/mL, significantly enhanced cell viability. The level of total glutathione in HepG2 cells treated with the fruit extract prior to the treatment of 40 mM acetaminophen was enhanced, however, the root extract failed for this activity. In addition, activities of quinone reductase, glutathione peroxidase and glutathione reductase were increased and protein levels of glutathione peroxidase 1 and superoxide dismutase 1 were enhanced in the cells treated with 10-20 μg/mL of the fruit extract. Furthermore, the protein level of Nrf2, a crucial regulator for detoxifying and antioxidant systems, was increased by the fruit extract treatment. These results suggest that the fruit extract of P. anomala exerts protective effects against acetaminophen-induced toxicity through activation of key antioxidant systems.DOI: http://dx.doi.org/10.5564/mjc.v14i0.190 Mongolian Journal of Chemistry 14 (40), 2013, p.5-1

Coumarins of Peucedanum baicalense and cytotoxic activity of some isolated coumarins

DOI: http://dx.doi.org/10.5564/mjc.v13i0.155 Mongolian Journal of Chemistry Vol.13 2012: 23-2

СИНТЕЗ И СВОЙСТВА БИОАКТИВНЫХ ОРГАНОМИНЕРАЛЬНЫХ КОМПОЗИТОВ ДЛЯ ЗАЩИТЫ КЕРАМИЧЕСКИХ ФИЛЬТРУЮЩИХ МАТЕРИАЛОВ

The method of obtaining hybrid organic biocidal structures through the interaction of the guanidine base with alumophosphates and copper hydroxy carbonate has been described. It is established that the reaction products consist of tripolyphosphates and pyrophosphates of aluminum forming ionic bonds with polyhexamethylene guanidine ions and copper (II). It is shown that when applied to the surface of a ceramic filter element at a temperature of 170 °C, a biocidal composite is fixed on them, on average, amounting to 50.0 wt. % of a product that provides the protection of filters from biofouling.Описан метод получения «гибридных» органоминеральных биоцидных структур путем взаимодействия основания полигексаметиленгуанидина с алюмофосфатами и гидрокарбонатом меди. Установлено, что продукты реакции состоят из триполифосфатов и пирофосфатов алюминия, образующих ионные связи с полигексаметиленгуанидином и ионами меди (II). Показано, что при нанесении на поверхности керамических фильтроэлементов при температуре 170 °С биоцидного композита на них закрепляется в среднем 50,0 масс. % продукта, обеспечивающего защиту фильтров от биообрастания

UniMorph 4.0:Universal Morphology

The Universal Morphology (UniMorph) project is a collaborative effort providing broad-coverage instantiated normalized morphological inflection tables for hundreds of diverse world languages. The project comprises two major thrusts: a language-independent feature schema for rich morphological annotation and a type-level resource of annotated data in diverse languages realizing that schema. This paper presents the expansions and improvements made on several fronts over the last couple of years (since McCarthy et al. (2020)). Collaborative efforts by numerous linguists have added 67 new languages, including 30 endangered languages. We have implemented several improvements to the extraction pipeline to tackle some issues, e.g. missing gender and macron information. We have also amended the schema to use a hierarchical structure that is needed for morphological phenomena like multiple-argument agreement and case stacking, while adding some missing morphological features to make the schema more inclusive. In light of the last UniMorph release, we also augmented the database with morpheme segmentation for 16 languages. Lastly, this new release makes a push towards inclusion of derivational morphology in UniMorph by enriching the data and annotation schema with instances representing derivational processes from MorphyNet

Preface Vol.12

DOI: http://dx.doi.org/10.5564/mjc.v12i0.161 Mongolian Journal of Chemistry Vol.12 201

Norditerpenoid alkaloids from Delphinium species

From the aerial parts of four Delphinium species 11 known and 3 new norditerpenoid alkaloids have been isolated: from D. dissectum Huth: delavaine A/B, deoxylycoctonine, methyllycaconitine;<br/> new: 10-hydroxymethyllycaconitine; from D. excelsum Reichenb.: delcaroline, delectinine, delterine, methyllycaconitine;<br/> new: 10-hydroxymethyllycaconitine, 18-O- methyldelterine and 10-hydroxynudicaulidine; from D. grandflorum L.: delcosine, deltatsine, grandiflorine, methyllycaconitine; from D. triste Fisch.: delcosine, macrocentridine, 14-dehydrodelcosine. The structures of the new alkaloids were established on the basis of MS, H-1, C-13, DEPT, homonuclear COSY, HMQC and HMBC NMR spectroscopic techniques