Experience of application for hygienic care of dentures devices based on ultraviolet radiation

We have developed a device based on ultraviolet radiation hygienic care tor dentures. For a com prehensive evaluation we developed the device, you need to compare it with others, the most com mon way of hygienic care. To achieve this goal were selected antiseptic soluble tablets Corega tabs. 10 patients took care of their dentures with the device based on the ultraviolet radiation of 10 patients - soluble antiseptic tablets Corega tabs. Found that the application of the selected m ethods for 1 week is a qualitative and quantitative changes in the m icroflora of the oral cavity.Нами было разработано устройство на основе ультрафиолетового излучения для гигиенического ухода за съемными зубными протезами. Для всесторонней оценки разработанного нами устройства, необходимо его сравнить с другим, наиболее распространенным способом гигиенического ухода. Для достижения зтой цели были выбраны антисептические растворимые таблетки Corega tabs. 10 пациентов ухаживали за своими съемными зубными протезами при помощи устройства на основе ультрафиолетового излучения, 10 пациентов - антисептическими растворимыми таблетками Corega tabs. Установлено, что при применении выбранных способов на протяжении 1 недели происходят качественные и количественные изменения микрофлоры полости рта

Search for the optimal method of hygienic care of removable dentures

We have developed a method for hygienic care of dentures, based on the action of electromagnetic radiation with a wavelength of 254 nm. But for a comprehensive assessment of our method, it is necessary to compare it with the other, the most common way of hygienic care. To achieve this goal were selected antiseptic soluble tablets Corega tabs. 10 patients cared for their dentures by UV radiation, 10 patsietov - antiseptic soluble tablets Corega tabs. It is established that the application of selected methods for 1 week for qualitative and quantitative changes in the microflora of the mouth.Нами был разработан метод гигиенического ухода за съемными зубными протезами, основанным на действии электромагнитного излучения с длиной волны 254 нм. Но для всесторонней оценки разработанного нами метода, необходимо его сравнить с другим, наиболее распространенным способом гигиенического ухода. Для достижения этой цели были выбраны антисептические растворимые таблетки Corega tabs. 10 пациентов ухаживали за своими съемными зубными протезами при помощи УФ-излучения, 10 пациентов - антисептическими растворимыми таблетками Corega tabs. Установлено, что при применении выбранных способов на протяжении 1 недели происходят качественные и количественные изменения микрофлоры полости рта

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Introduction. Based on the knowledge of early gestational disorders related to metabolic syndrome (MS), pathogenetically relevant preventive treatment meeting the requirements of perinatal pharmacology can be developed. Aim. To reveal clinical and laboratory characteristics of early pregnancy and develop pathogenetically relevant preventive monotherapy for unfavorable gestational and perinatal outcomes in women with metabolic syndrome. Material and methods. A total of 230 women were investigated and divided into four groups: Group I consisted of 68 pregnant women with MS who refused any preventive measures; Group II comprised 97 women with MS who received periconceptional preventive monotherapy with dydrogesterone, a progestagen; Group III consisted of 35 healthy primigravidas women with physiological course of gestation; Group IV comprised 30 healthy non-pregnant women. Laboratory testing during I–III trimesters allowed to assess the dynamics demonstrated by markers of lipid spectrum, endothelial dysfunction, apoptosis, decidualization, energy metabolism, and immunomodulation. Results. A balance between factors of physiological damage and gestational adaptation in the course of physiological pregnancy has been shown to be of primary significance. In women with MS, embryo-placental dysfunction develops during early pregnancy, and this stage is preceding for major obstetric syndromes. Preventive administration of dydrogesterone in women with MS appeared highly effective: NNT (number needed to treat) was 1.33 (95% CI 0.9–1.8); OR 5.2 (95% CI 4.6–5.7). Conclusion. Pregestational changes and atherogenic profile of gestational process determine the course of early pregnancy in women with MS with the development of embryo-placental dysfunction and major obstetric syndromes. High efficacy in the prevention of unfavorable gestational and perinatal outcomes was shown by preventive dydrogesterone monotherapy

The use of ultraviolet irradiation for hygienic care of removable prosthetic constructions

Due to the fact that existing methods of processing dentures, or are not effective or expensive, we have begun studies to determine if the use of ultraviolet radiation for hygienic care of removable prosthetic constructions. Our studies are aimed at creating a simple, reliable and cost-effective algorithm for the care of dentures. To do this, it was decided to investigate the effect of ultraviolet irradiation on the microflora, colonizing removable orthotic design dental patients. As the test material was used to scrape the gum surface structures before and after UV irradiation. We found that on removable prosthetic constructions are found staphylococci, streptococci, protozoa, Pseudomonas aeruginosa, yeast-like fungi. After UV denture for 1 hour in 60% of the observed effect of sterilization. In 40% of the flora on the prosthesis is stored and presented to yeast-like fungi of the genus Candida and Neisseria spp. In this regard, we plan to develop a phased cleaning and sterilization of orthopedic construction with UV.В связи с тем, что существующие методы обработки зубных протезов или мало эффективны или дорогостоящи, мы начали исследования по определению возможности использования ультрафиолетового излучения для гигиенического ухода за съемными ортопедическими конструкциями. Наши исследования нацелены на создание простого, надежного и экономически выгодного алгоритма ухода за протезами. Для этого решено было исследовать действие УФО на микрофлору, колонизирующую съемные ортопедические конструкции стоматологических пациентов. В качестве исследуемого материала был использован соскоб с десневой поверхности конструкции до и после УФ облучения. Нами обнаружено, что на съемных ортопедических конструкциях встречаются стафилококки, стрептококки, нейссерии, синегнойная палочка, дрожжеподобные грибы. После УФО зубного протеза в течение 1 часа в 60% случаев наблюдается эффект стерилизации. В 40% случаев флора на протезе сохраняется и представлена дрожжеподобными грибами рода Candida и Neisseria spp. В связи с этим, планируется разработка поэтапной очистки и стерилизации ортопедической конструкции с применением УФО

Association between placental insufficiency and manifestations of preeclampsia

Aim. Provide evidence for the connection between placental insufficiency and preeclampsia and rationalize a unified approach to the prevention of placenta associated disorders. Materials and methods. The study was carried out in two stages. At the first (clinical statistical) stage, the incidence rates of preeclampsia (PE) and placental insufficiency (PI) were compared based on the data from Rosstat and from a regional perinatal center for the past 25 years; the most informative predictors of PI and PE were compared using the known clinical epidemiological tests. At the second stage, a prospective study of 140 high-risk pregnant patients with severe PI was carried out to confirm and generalize the hypothesis on the common predictors of PI and PE. Two groups of patients were compared: I – 68 women with isolated PI and II – 72 women with PI combined with earlyor late-onset PE. The control group included 30 women with uncomplicated pregnancy. Immunoenzyme assays, immunofluorescence, biochemical analyses, and morphological studies of placenta were used. Results. The incidence rates of PI and PE, both in the communities and in the tertiary care hospital, pointed to their intercorrelation. This similarity of informative values of PI and PE predictors related to the most important operational characteristics of clinical epidemiology indicates the lack of pathognomonic significance of the early predictors and, on the other hand, supports the concept of the common mechanisms of placenta-associated pregnancy complications. In pregnant women with a high risk of PI decompensation, PE developed in 51% of cases (early-onset – 72%, late-onset – 28%); of those, 18% were diagnosed with severe PE, and 33% – with moderate PE. The obtained data confirm that the manifestation of early-onset PE is pathogenetically related to structural and functional disorders of the early fetoplacental complex (FPC), while late-onset PE is associated with FPC changes in the subsequent stages of pregnancy, and with a synergistic effect of extragenital and obstetrical pathology. The proposed predictive model of PE connects the manifestation of PE with the status of the placenta. Conclusion. The knowledge of pathogenetically significant risk factors allows for stratifying pregnant women in order to conduct a common preventive monotherapy of placenta associated disorders. The present approach to the management of high-risk pregnancy is in line with the principles of 4Р-medicine

Combined Use of Vaccination and Immunotherapy Drugs to Achieve a Long-Term Clinical Remission in Patients with Chronic HPV-infection Manifested in condyloma accuminata of the anogenital area

Study objective. The study aims at evaluating the efficacy of combined administration of imiquimod 5% cr me and human papillomavirus (HPV) quadrivalent recombinant vaccine in order to achieve a long-term clinical remission in patients with chronic HPV infection manifested in condyloma accuminata of the anogenital area. Materials and Methods. The study enrolled 36 subjects aged 26.4 (4.1) years (including 22 men) with 1 to 5 condyloma accuminata of the anogenital area. Study participants were vaccinated with human papillomavirus quadrivalent recombinant vaccine using a 0 - 2 - 6 month regimen with concomitant administration of imiquimod 5% cr me applied 3 times per week for not more than 16 weeks. Results. Complete disappearance of condyloma accuminata was observed in 34 out of 36 subjects (94.4%) after one year from the start of treatment. Two patients still having condyloma accuminata of the anogenital area after one year of combination treatment underwent a successful course of treatment with solcoderm (one patient for 1 year 3 months and the other for 1 year 4 months) that resulted in complete disappearance of condyloma accuminata. Within the 1 year 6 month period no recurrence of condyloma accuminata of the anogenital area has been observed. Conclusion. Vaccination with human papillomavirus quadrivalent recombinant vaccine along with concomitant use of imiquimod 5% cr me enables to achieve a long-term clinical remission in patients with chronic HPV infection manifesting in condyloma accuminata of the anogenital area, in at least 94.4% of patients followed up for 1 year 6 months

MICROFLORA OF THE ORAL CAVITY AND CONDITION OF ANTI-INFECTION PROTECTION FACTORS IN PERSONS USING DENTAL ORTHOPEDIC CONSTRUCTIONS (DOC)

Aim. To study the qualitative composition, the quantitative content of microorganisms, to assess the viability and functional status of neutrophils in the oral fluid of patients using removable and non-removable DOC. Materials and methods. The present study used a free oral fluid of 100 patients aged 21 to 79 years. The qualitative and quantitative composition of the microflora was determined using the PCR method by means of the Femoflor-16 system (NPO DNA-technology, Russia). Determination of the total number of leukocytes was carried out in Goryaev's chamber, analysis of their viability was carried out with Trypan blue staining. Acridine orange was used to study the indices of lysosomal activity of neutrophils. Oxygendependent metabolism was studied using the Nitro Blue-Tetrazolium (NBT) test, and the phagocytic function was determined by the absorption of latex particles. Results. In persons using dentures, the qualitative and quantitative composition of the microflora of the oral cavity changes. The method of hygienic care of the DOC significantly does not affect the composition of the microflora of the oral fluid of patients. In persons using DOC, a decrease in the total number of leukocytes and their viable forms in the free oral fluid was established. However we registered the stability of functioning of viable neutrophils in patients with removable DOC and a significant decrease in the phagocytic ability and microbicidal oxygen-dependent potential of neutrophils when using non-removable DOC. Conclusion. Foreign body in the form of a removable or non-removable DOC changes the functioning of the factors of congenital anti-infective protection of the oral mucosa, which can lead to the development of infectious complications during dental prosthetics

Influence of pregnancy and birth factors on the development of acute kidney injury in premature infants

The Objective of this article is to assess the influence of the factors of pregnancy, childbirth and the early neonatal period on the development of acute kidney damage in premature newborns with very low and extremely low body weight. In addition, this disease significantly affects the prognosis and quality of life of the child. In addition, acute kidney damage significantly increases mortality among patients of the intensive care unit for newborns. There has been established a connection between acute hypoxia in childbirth, extremely low body weight at birth, intrauterine infection and III severity on the NTISS scale with the development of acute kidney damage in the early neonatal period. Early detection of this condition requires a comprehensive study of the mechanisms of its development and possible risk factors

Characteristics of early pregnancy and prevention of gestational and perinatal complications in women with metabolic syndrome

Introduction. Based on the knowledge of early gestational disorders related to metabolic syndrome (MS), pathogenetically relevant preventive treatment meeting the requirements of perinatal pharmacology can be developed. Aim. To reveal clinical and laboratory characteristics of early pregnancy and develop pathogenetically relevant preventive monotherapy for unfavorable gestational and perinatal outcomes in women with metabolic syndrome. Material and methods. A total of 230 women were investigated and divided into four groups: Group I consisted of 68 pregnant women with MS who refused any preventive measures; Group II comprised 97 women with MS who received periconceptional preventive monotherapy with dydrogesterone, a progestagen; Group III consisted of 35 healthy primigravidas women with physiological course of gestation; Group IV comprised 30 healthy non-pregnant women. Laboratory testing during I–III trimesters allowed to assess the dynamics demonstrated by markers of lipid spectrum, endothelial dysfunction, apoptosis, decidualization, energy metabolism, and immunomodulation. Results. A balance between factors of physiological damage and gestational adaptation in the course of physiological pregnancy has been shown to be of primary significance. In women with MS, embryo-placental dysfunction develops during early pregnancy, and this stage is preceding for major obstetric syndromes. Preventive administration of dydrogesterone in women with MS appeared highly effective: NNT (number needed to treat) was 1.33 (95% CI 0.9–1.8); OR 5.2 (95% CI 4.6–5.7). Conclusion. Pregestational changes and atherogenic profile of gestational process determine the course of early pregnancy in women with MS with the development of embryo-placental dysfunction and major obstetric syndromes. High efficacy in the prevention of unfavorable gestational and perinatal outcomes was shown by preventive dydrogesterone monotherapy