Phenotypic Peculiarities of Pathogenic <i>Burkholderia</i> Mutants Resistant to Fluoroquinolones and Cephalosporins

Examined were phenotypic peculiarities of mutants of Burkholderia phylogenetically-related pathogenic species (B. pseudomallei, B. mallei, B. cepacia) resistant to fluoroquinolones and cephalosporins. It was shown that strains with PfxR (OfxR), CfzR markers acquire high multi-drug resistance to antibiotics of different classes. Strain resistance changes under blocking influence of verapamil - inhibitor of calcium membrane channels. Mutant strains differ in production of extracellular enzymes (proteases, lecithinase, lipase) and virulence

MODELING AND PREDICTION OF SENSITIVITY IN ENERGETIC MATERIALS

Abstract. Sensitivity prediction is a complex problem. Many studies attempted to correlate experimental data with molecular and microscopic features. In the context of the well-recognized macroscopic hot spot model, an application of an original approach to predict impact sensitivity of 11 explosives is described in terms of parameters of explosive decomposition. This model provides a useful tool in the research for new explosives and the results do not depend on the calculation of solid-state formation enthalpy of explosives