Inertial range scaling in numerical turbulence with hyperviscosity

Numerical turbulence with hyperviscosity is studied and compared with direct simulations using ordinary viscosity and data from wind tunnel experiments. It is shown that the inertial range scaling is similar in all three cases. Furthermore, the bottleneck effect is approximately equally broad (about one order of magnitude) in these cases and only its height is increased in the hyperviscous case--presumably as a consequence of the steeper decent of the spectrum in the hyperviscous subrange. The mean normalized dissipation rate is found to be in agreement with both wind tunnel experiments and direct simulations. The structure function exponents agree with the She-Leveque model. Decaying turbulence with hyperviscosity still gives the usual t^{-1.25} decay law for the kinetic energy, and also the bottleneck effect is still present and about equally strong.Comment: Final version (7 pages

Focused Crossed Andreev Reflection

We consider non-local transport in a system with one superconducting and two normal metal terminals. Electron focusing by weak perpendicular magnetic fields is shown to tune the ratio between crossed Andreev reflection (CAR) and electron transfer (ET) in the non-local current response. Additionally, electron focusing facilitates non-local signals between normal metal contacts where the separation is as large as the mean free path rather than being limited by the coherence length of the superconductor. CAR and ET can be selectively enhanced by modulating the magnetic field

The onset of a small-scale turbulent dynamo at low magnetic Prandtl numbers

We study numerically the dependence of the critical magnetic Reynolds number Rmc for the turbulent small-scale dynamo on the hydrodynamic Reynolds number Re. The turbulence is statistically homogeneous, isotropic, and mirror--symmetric. We are interested in the regime of low magnetic Prandtl number Pm=Rm/Re<1, which is relevant for stellar convective zones, protostellar disks, and laboratory liquid-metal experiments. The two asymptotic possibilities are Rmc->const as Re->infinity (a small-scale dynamo exists at low Pm) or Rmc/Re=Pmc->const as Re->infinity (no small-scale dynamo exists at low Pm). Results obtained in two independent sets of simulations of MHD turbulence using grid and spectral codes are brought together and found to be in quantitative agreement. We find that at currently accessible resolutions, Rmc grows with Re with no sign of approaching a constant limit. We reach the maximum values of Rmc~500 for Re~3000. By comparing simulations with Laplacian viscosity, fourth-, sixth-, and eighth-order hyperviscosity and Smagorinsky large-eddy viscosity, we find that Rmc is not sensitive to the particular form of the viscous cutoff. This work represents a significant extension of the studies previously published by Schekochihin et al. 2004, PRL 92, 054502 and Haugen et al. 2004, PRE, 70, 016308 and the first detailed scan of the numerically accessible part of the stability curve Rmc(Re).Comment: 4 pages, emulateapj aastex, 2 figures; final version as published in ApJL (but with colour figures

Loss of heterozygosity is related to p53 mutations and smoking in lung cancer

Carcinogenesis results from an accumulation of several genetic alterations. Mutations in the p53 gene are frequent and occur at an early stage of lung carcinogenesis. Loss of multiple chromosomal regions is another genetic alteration frequently found in lung tumours. We have examined the association between p53 mutations, loss of heterozygosity (LOH) at frequently deleted loci in lung cancer, and tobacco exposure in 165 tumours from non-small cell lung cancer (NSCLC) patients. A highly significant association between p53 mutations and deletions on 3p, 5q, 9p, 11p and 17p was found. There was also a significant correlation between deletions at these loci. 86% of the tumours with concordant deletion in the 4 most involved loci (3p21, 5q11–13, 9p21 and 17p13) had p53 mutations as compared to only 8% of the tumours without deletions at the corresponding loci (P< 0.0001). Data were also examined in relation to smoking status of the patients and histology of the tumours. The frequency of deletions was significantly higher among smokers as compared to non-smokers. This difference was significant for the 3p21.3 (hMLH1 locus), 3p14.2 (FHIT locus), 5q11–13 (hMSH3 locus) and 9p21 (D9S157 locus). Tumours with deletions at the hMLH1 locus had higher levels of hydrophobic DNA adducts. Deletions were more common in squamous cell carcinomas than in adenocarcinomas. Covariate analysis revealed that histological type and p53 mutations were significant and independent parameters for predicting LOH status at several loci. In the pathogenesis of NSCLC exposure to tobacco carcinogens in addition to clonal selection may be the driving force in these alterations. © 2001 Cancer Research Campaign http://www.bjcancer.co

Microbial-Induced Heterogeneity in the Acoustic Properties of Porous Media

It is not known how biofilms affect seismic wave propagation in porous media. Such knowledge is critical for assessing the utility of seismic techniques for imaging biofilm development and their effects in field settings. Acoustic wave data were acquired over a two-dimensional region of a microbial-stimulated sand column and an unstimulated sand column. The acoustic signals from the unstimulated column were relatively uniform over the 2D scan region. The data from the microbial-stimulated column exhibited a high degree of spatial heterogeneity in the acoustic wave amplitude, with some regions exhibiting significant increases in attenuation while others exhibited decreases. Environmental scanning electron microscopy showed differences in the structure of the biofilm between regions of increased and decreased acoustic wave amplitude. We conclude from these observations that variations in microbial growth and biofilm structure cause heterogeneity in the elastic properties of porous media with implications for the validation of bioclogging models

Allele diversity of the H-ras-1 variable number of tandem repeats in Norwegian lung cancer patients

We have examined restriction fragment length polymorphisms of the H-ras-1 gene in germ-line DNA from 214 lung cancer patients and 309 unaffected controls. When DNA samples were digested with MspI/HpaII, Southern blot analysis revealed at least 22 different alleles, grouped according to their frequencies as common, intermediate, and rare. The frequency of rare alleles in lung cancer patients (16/428) is significantly different (p = 0.002) from that in the control group (5/618). Individuals with rare alleles were found to be at 4.7-fold greater risk of lung cancer than those with no rare alleles.publishedVersio

Cyanobacterial ribosomal RNA genes with multiple, endonuclease-encoding group I introns

<p>Abstract</p> <p>Background</p> <p>Group I introns are one of the four major classes of introns as defined by their distinct splicing mechanisms. Because they catalyze their own removal from precursor transcripts, group I introns are referred to as autocatalytic introns. Group I introns are common in fungal and protist nuclear ribosomal RNA genes and in organellar genomes. In contrast, they are rare in all other organisms and genomes, including bacteria.</p> <p>Results</p> <p>Here we report five group I introns, each containing a LAGLIDADG homing endonuclease gene (HEG), in large subunit (LSU) rRNA genes of cyanobacteria. Three of the introns are located in the LSU gene of <it>Synechococcus </it>sp. C9, and the other two are in the LSU gene of <it>Synechococcus lividus </it>strain C1. Phylogenetic analyses show that these introns and their HEGs are closely related to introns and HEGs located at homologous insertion sites in organellar and bacterial rDNA genes. We also present a compilation of group I introns with homing endonuclease genes in bacteria.</p> <p>Conclusion</p> <p>We have discovered multiple HEG-containing group I introns in a single bacterial gene. To our knowledge, these are the first cases of multiple group I introns in the same <it>bacterial </it>gene (multiple group I introns have been reported in at least one phage gene and one prophage gene). The HEGs each contain one copy of the LAGLIDADG motif and presumably function as homodimers. Phylogenetic analysis, in conjunction with their patchy taxonomic distribution, suggests that these intron-HEG elements have been transferred horizontally among organelles and bacteria. However, the mode of transfer and the nature of the biological connections among the intron-containing organisms are unknown.</p

Revisiting Semantics of Interactions for Trace Validity Analysis

Interaction languages such as MSC are often associated with formal semantics by means of translations into distinct behavioral formalisms such as automatas or Petri nets. In contrast to translational approaches we propose an operational approach. Its principle is to identify which elementary communication actions can be immediately executed, and then to compute, for every such action, a new interaction representing the possible continuations to its execution. We also define an algorithm for checking the validity of execution traces (i.e. whether or not they belong to an interaction's semantics). Algorithms for semantic computation and trace validity are analyzed by means of experiments.Comment: 18 pages of contents and 2 pages for references, 10 figures. Published in ETAPS-FASE2020 : "23rd International Conference on Fundamental Approaches to Software Engineering" in the "research papers" categor

On the Saturation of Astrophysical Dynamos: Numerical Experiments with the No-cosines flow

In the context of astrophysical dynamos we illustrate that the no-cosines flow, with zero mean helicity, can drive fast dynamo action and study the dynamo's mode of operation during both the linear and non-linear saturation regime: It turns out that in addition to a high growth rate in the linear regime, the dynamo saturates at a level significantly higher than normal turbulent dynamos, namely at exact equipartition when the magnetic Prandtl number is on the order of unity. Visualization of the magnetic and velocity fields at saturation will help us to understand some of the aspects of the non-linear dynamo problem.Comment: 8 pages, 5 figures, submitted to the proceedings of "Space Climate 1" to be peer-reviewed to Solar Physic