22,835 research outputs found
Residual Stresses in Layered Manufacturing
Layered Manufacturing processes accumulate residual stresses during materialbuildup. These stresses may cause part warping and layer delamination. This paper presents
work done on investigating residual stress accumulation andp(i,rt distortion of Layered
Manufactured artifacts. A simple analyticaLmodel was developed and used to determine how the number of layers and the layer thickness influences part warping. Resllits
show that thin layers produce lower part deflection as compared with depositing fewer
and thicker layers. In addition to the analytical work, a finite element model wasdeveloped and used to illvestigate the deposition pattern's influence on. the part deflection.
Finite element model and corresponding experimental analysis showed that the geometry of the deposition pattern significantly affects the resulting part distortion. This
finite element model was also used to investigate an inter-layer surface defect,. known
as the Christmas Thee Step, that is associated with Shape Deposition Manufacturing.
Results indicate that the features of this defect are influenced only by the material
deposited close. to the part·surface and the particular material deposited. The step is
not affected by the deposition pattern.Mechanical Engineerin
Temperature dependence of the average electron-hole pair creation energy in Al0.8Ga0.2As
The temperature dependence of the average energy consumed in the creation of an electron-hole pair in the wide bandgap compound semiconductor Al 0.8Ga0.2As is reported following X-ray measurements made using an Al0.8Ga0.2As photodiode diode coupled to a low-noise charge-sensitive preamplifier operating in spectroscopic photon counting mode. The temperature dependence is reported over the range of 261 K-342 K and is found to be best represented by the equation ε AlGaAs 7.327-0.0077 T, where εAlGaAs is the average electron-hole pair creation energy in eV and T is the temperature in K. © 2013 © 2013 Author(s)
Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model
<b>Background and Purpose</b><p></p>
cAMP and pharmacological inhibition of PDE4, which degrades it, are promising therapeutic targets for the treatment of spinal cord injury (SCI). Using our previously described in vitro SCI model, we studied the mechanisms by which cAMP modulators promote neurite outgrowth and myelination using enantiomers of the PDE4-specific inhibitor rolipram and other modulators of downstream signalling effectors.<p></p>
<b>Experimental Approach</b><p></p>
Rat mixed neural cell myelinating cultures were cut with a scalpel and treated with enantiomers of the PDE4-specific inhibitor rolipram, Epac agonists and PKA antagonists. Neurite outgrowth, density and myelination were assessed by immunocytochemistry and cytokine levels analysed by qPCR.<p></p>
<b>Key Results</b><p></p>
Inhibition of the high-affinity rolipram-binding state (HARBS), rather than the low-affinity rolipram binding state (LARBS) PDE4 conformer promoted neurite outgrowth and myelination. These effects were mediated through the activation of Epac and not through PKA. Expression of the chemokine CXCL10, known to inhibit myelination, was markedly elevated in astrocytes after Rho inhibition and this was blocked by inhibition of Rho kinase or PDE4.<p></p>
<b>Conclusions and Implications</b><p></p>
PDE4 inhibitors targeted at the HARBS conformer or Epac agonists may provide promising novel targets for the treatment of SCI. Our study demonstrates the differential mechanisms of action of these compounds, as well as the benefit of a combined pharmacological approach and highlighting potential promising targets for the treatment of SCI. These findings need to be confirmed in vivo
Antiferromagnetic Spinor Condensates are Quantum Rotors
We establish a theoretical correspondence between spin-one antiferromagnetic
spinor condensates in an external magnetic field and quantum rotor models in an
external potential. We show that the rotor model provides a conceptually clear
picture of the possible phases and dynamical regimes of the antiferromagnetic
condensate. We also show that this mapping simplifies calculations of the
condensate's spectrum and wavefunctions. We use the rotor mapping to describe
the different dynamical regimes recently observed in Na condensates. We
also suggest a way to experimentally observe quantum mechanical effects
(collapse and revival) in spinor condensates.Comment: minor revisions. some typos correcte
Inequalities in maternity care and newborn outcomes: one-year surveillance of births in vulnerable slum communities in Mumbai
Background: Aggregate urban health statistics mask inequalities. We described maternity care in
vulnerable slum communities in Mumbai, and examined differences in care and outcomes between
more and less deprived groups.
Methods: We collected information through a birth surveillance system covering a population of
over 280 000 in 48 vulnerable slum localities. Resident women identified births in their own
localities and mothers and families were interviewed at 6 weeks after delivery. We analysed data
on 5687 births over one year to September 2006. Socioeconomic status was classified using
quartiles of standardized asset scores.
Results: Women in higher socioeconomic quartile groups were less likely to have married and
conceived in their teens (Odds ratio 0.74, 95% confidence interval 0.69–0.79, and 0.82, 0.78–0.87,
respectively). There was a socioeconomic gradient away from public sector maternity care with
increasing socioeconomic status (0.75, 0.70–0.79 for antenatal care and 0.66, 0.61–0.71 for
institutional delivery). Women in the least poor group were five times less likely to deliver at home
(0.17, 0.10–0.27) as women in the poorest group and about four times less likely to deliver in the
public sector (0.27, 0.21–0.35). Rising socioeconomic status was associated with a lower
prevalence of low birth weight (0.91, 0.85–0.97). Stillbirth rates did not vary, but neonatal mortality
rates fell non-significantly as socioeconomic status increased (0.88, 0.71–1.08).
Conclusion: Analyses of this type have usually been applied across the population spectrum from
richest to poorest, and we were struck by the regularly stepped picture of inequalities within the
urban poor, a group that might inadvertently be considered relatively homogeneous. The poorest
slum residents are more dependent upon public sector health care, but the regular progression
towards the private sector raises questions about its quality and regulation. It also underlines the
need for healthcare provision strategies to take account of both sectors
Retrodiction of Generalised Measurement Outcomes
If a generalised measurement is performed on a quantum system and we do not
know the outcome, are we able to retrodict it with a second measurement? We
obtain a necessary and sufficient condition for perfect retrodiction of the
outcome of a known generalised measurement, given the final state, for an
arbitrary initial state. From this, we deduce that, when the input and output
Hilbert spaces have equal (finite) dimension, it is impossible to perfectly
retrodict the outcome of any fine-grained measurement (where each POVM element
corresponds to a single Kraus operator) for all initial states unless the
measurement is unitarily equivalent to a projective measurement. It also
enables us to show that every POVM can be realised in such a way that perfect
outcome retrodiction is possible for an arbitrary initial state when the number
of outcomes does not exceed the output Hilbert space dimension. We then
consider the situation where the initial state is not arbitrary, though it may
be entangled, and describe the conditions under which unambiguous outcome
retrodiction is possible for a fine-grained generalised measurement. We find
that this is possible for some state if the Kraus operators are linearly
independent. This condition is also necessary when the Kraus operators are
non-singular. From this, we deduce that every trace-preserving quantum
operation is associated with a generalised measurement whose outcome is
unambiguously retrodictable for some initial state, and also that a set of
unitary operators can be unambiguously discriminated iff they are linearly
independent. We then examine the issue of unambiguous outcome retrodiction
without entanglement. This has important connections with the theory of locally
linearly dependent and locally linearly independent operators.Comment: To appear in Physical Review
s-ordered phase-sum and phase-difference distribuitons of entangled coherent states
The -ordered phase-sum and phase-difference distributions are considered
for Bell-like superpositions of two-mode coherent states. The distributions are
sensitive, respectively, to the sum and difference of the phases of the
entangled coherent states. They show loss of information about the entangled
state and may take on negative values for some orderings .Comment: 8 pages, 2 figures, iopart. accepted for publication in J. Opt. B:
Quantum Semiclass Op
Experimental Demonstration of Optimal Unambiguous State Discrimination
We present the first full demonstration of unambiguous state discrimination
between non-orthogonal quantum states. Using a novel free space interferometer
we have realised the optimum quantum measurement scheme for two non-orthogonal
states of light, known as the Ivanovic-Dieks-Peres (IDP) measurement. We have
for the first time gained access to all three possible outcomes of this
measurement. All aspects of this generalised measurement scheme, including its
superiority over a standard von Neumann measurement, have been demonstrated
within 1.5% of the IDP predictions
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