Safety and Effectiveness of the Genous™ Endothelial Progenitor Cell-Capture Stent in the First Year Following ST-Elevation Acute Myocardial Infarction: A Single Center Experience and Review of the Literature

PURPOSE: The Genous™ stent (GS) is designed to accelerate endothelization, which is potentially useful in the pro-thrombotic environment of ST-elevation acute myocardial infarction (STEMI). We aimed to evaluate the safety and effectiveness of the GS in the first year following primary percutaneous coronary intervention (PCI) and to compare our results with the few previously published studies. METHODS AND MATERIALS: All patients admitted to a single center due to STEMI that underwent primary PCI using exclusively GS, between May 2006 and January 2012, were enrolled. The primary study endpoints were major adverse cardiac events (MACEs), defined as the composite of cardiac death, acute myocardial infarction and target vessel revascularization, at one and 12months. RESULTS: In the cohort of 109 patients (73.4% male, 59 ±12years), 24.8% were diabetic. PCI was performed in 116 lesions with angiographic success in 99.1%, using 148 GS with median diameter of 3.00mm (2.50-4.00) and median length of 15mm (9-33). Cumulative MACEs were 2.8% at one month and 6.4% at 12months. Three stent thromboses (2.8%), all subacute, and one stent restenosis (0.9%) occurred. These accounted for the four target vessel revascularizations (3.7%). At 12months, 33.9% of patients were not on dual antiplatelet therapy. CONCLUSIONS: GS was safe and effective in the first year following primary PCI in STEMI, with an apparently safer profile comparing with the previously published data. SUMMARY: We report the safety and effectiveness of the Genous™ stent (GS) in the first year following primary percutaneous coronary intervention in ST-elevation acute myocardial infarction. A comprehensive review of the few studies that have been published on this subject was included and some suggest a less safe profile of the GS. Our results and the critical review included may add information and reinforce the safety and effectiveness of the GS in ST-elevation in acute myocardial infarction

Safety and Effectiveness of the Genous Endothelial Progenitor Cell-Capture Stent: Follow-Up to 5 Years

AIMS: To evaluate the long-term clinical outcomes following percutaneous coronary intervention (PCI) with the Genous stent in an unselected population. METHODS: All patients admitted to a single center who underwent PCI using the GS exclusively, between May 2006 and May 2012, were enrolled, and a clinical follow-up of up to 60 months was carried out. The primary endpoint of major adverse cardiac event (MACE) rate was defined as the composite of cardiac death, acute myocardial infarction (AMI), and target lesion revascularization (TLR). RESULTS: Of the 450 patients included (75.1% male; 65.5 ± 11.7 years), 28.4% were diabetic and acute coronary syndrome was the reason for PCI in 76.4%. Angioplasty was performed in 524 lesions using 597 Genous stents, with angiographic success in 97.1%. At a median of 36 months of follow-up (range, 1-75 months), MACE, AMI, TLR, stent restenosis (SR), and stent thrombosis (ST) rates were 15.6%, 8.4%, 4.4%, 3.8%, and 2.2%, respectively. Between 12 and 24 months, the TLR, SR, and ST rates practically stabilized, up to 60 months. Bifurcation lesions were independently associated with MACE, TLR, and SR. CONCLUSION: This is the first study reporting clinical results with the Genous stent up to 60 months. The Genous stent was safe and effective in the long-term, in an unselected population

Fatigue analysis of thin AlMgSi welded joints under constant and variable amplitude block loadings

This paper reports the fatigue behaviour of thin AlMgSi1 aluminium alloy weldments and the improvement in fatigue strength due to post-weld treatments. Several fatigue tests were performed using two distinct types of thin welded joints, T and single lap, manufactured using a 6xxx series aluminium alloy, and the efficiency of fatigue life improvement techniques, such as post-weld heat treatment and weld toe's burr dressing, was studied. Both the post-weld heat treatment and the burr dressing produced a fatigue strength improvement. This fact is discussed, for both geometries, in the context of the initiation and propagation phases contribution to total fatigue life. Finally, several fatigue tests were performed under variable amplitude block loading using T6 post-weld heat-treated single lap joints, and the correspondent fatigue lives were compared with the predictions of Miner's rule.http://www.sciencedirect.com/science/article/B6V59-480CN2C-2/1/ef6815883b0431d9a8aa0d0d77743ff

Criação de bezerras leiteiras.

A criação de bezerras, fase que será discutida neste capítulo, compreende não apenas a fase de criação per si, mas também o período que antecede seu nascimento (o período seco das vacas, aproximadamente 60 dias antes do parto). Os aspectos práticos mais importantes que permitem a melhoria dos sistemas de criação de bezerras do nascimento até o desmame são os seguintes: os cuidados no período do pré-parto até o nascimento, instalações, manejo ao nascimento, cuidados durante o período de cria, saúde da bezerra, cuidados após a desmama e controle dos índices zootécnicos.bitstream/item/217363/1/cpafro-18464.pd

Apoptosis of non-parasitized red blood cells in malaria: a putative mechanism involved in the pathogenesis of anaemia

<p>Abstract</p> <p>Background</p> <p>Severe anaemia is a common complication of <it>Plasmodium falciparum </it>malaria in hyperendemic regions. Premature elimination of non-parasitized red blood cells (nRBC) has been considered as one mechanism involved in the genesis of severe malaria anaemia. It has been reported that apoptosis can occur in RBC and, consequently, this cell death process could contribute to anaemia. This study was performed to evaluate the susceptibility of nRBC to apoptosis in a malaria anaemia murine model.</p> <p>Methods</p> <p>Balb/c mice were intraperitonially inoculated with 1 × 10⁶<it>P. yoelii </it>17XL parasitized RBC (pRBC) and, then, parasitaemia and anaemia were monitored. Apoptosis in both pRBC and nRBC was assessed during early and late phases of infection by flow cytometry using Syto 16 and annexin V-PE double staining and forward scatter measurement.</p> <p>Results</p> <p>As expected, experimental infection of Balb/c mice with <it>Plasmodium yoelii </it>17XL parasites was characterized by progressive increase of parasitaemia and acute anaemia, leading to death. Flow cytometry analysis showed that a number of pRBC was in the apoptotic process. It was noteworthy that the increase of nRBC apoptosis levels occurred in the late phase of infection, when anaemia degree was notably accentuated, while no significant alteration was observed in the early phase.</p> <p>Conclusion</p> <p>The increased levels of nRBC apoptosis herein firstly reported, in malaria infection could represent a putative mechanism worsening the severity of malarial anaemia.</p

Comportamento de clones de café conilon em dois maroambientes da Região Norte do Estado do Espírito Santo.

O objetivo do trabalho foi avaliar o comportamento de materiais genéticos de café conilon para diferentes características em dois macroambientes do Estado do Espírito Santo. Foram avaliadas oito características de quarenta genótipos do programa de melhoramento genético de café conilon do Instituto Capixaba de Pesquisa, Assistência Técnica e Extensão Rural (Incaper), em Sooretama e Marilândia (ES), no período de 1996 a 2000. O delineamento experimental foi o de blocos casualizados com seis repetições. A análise de variância conjunta e avaliação de similaridade entre os genótipos, pelo critério Scott e Knott a 5% de probabilidade, mostraram: necessidade de maior atenção do melhorista para interação temporal; as condições são favoráveis para a obtenção de ganhos genéticos para a maioria das características estudadas; os clones de destaque foram os ES 313, ES 325, ES 326, ES 327, ES 328, ES 329, ES 336, ES 337 e ES 340 (Sooretama, ES) e os ES 309, ES 310, ES 312, ES 314, ES 327, ES 328, ES 329 e ES 337 (Marilândia, ES)

Manejo da cultura do milheto.

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