Electron transmission and phase time in semiconductor superlattices

We discuss the time spent by an electron propagating through a finite periodic system such as a semiconductor superlattice. The relation between dwell-time and phase-time is outlined. The envelopes of phase-time at maximum and minimum transmission are derived, and it is shown that the peaks and valleys of phase-time can be well described by parameters fitted at the extrema. For a many-period system this covers most of the allowed band. Comparison is made to direct numerical solutions of the time-dependent Schr\"odinger equation by Veenstra et al. [cond-mat/0411118] who compared systems with and without addition of an anti-reflection coating (ARC). With an ARC, the time delay is consistent with propagation at the Bloch velocity of the periodic system, which significantly reduces the time delay, in addition to increasing the transmissivity.Comment: 8 pages, 10 figures, based on a talk at Theory-Canada 3 in Edmonton AB, June 200

Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

Nasopharyngeal cancer (NPC), endemic in Southeast Asia, lacks effective diagnostic and therapeutic strategies. Even in high-income countries the 5-year survival rate for stage IV NPC is less than 40%. Here we report high somatostatin receptor 2 (SSTR2) expression in multiple clinical cohorts comprising 402 primary, locally recurrent and metastatic NPCs. We show that SSTR2 expression is induced by the Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) via the NF-kappa B pathway. Using cell-based and preclinical rodent models, we demonstrate the therapeutic potential of SSTR2 targeting using a cytotoxic drug conjugate, PEN-221, which is found to be superior to FDA-approved SSTR2-binding cytostatic agents. Furthermore, we reveal significant correlation of SSTR expression with increased rates of survival and report in vivo uptake of the SSTR2-binding Ga-68-DOTA-peptide radioconjugate in PET-CT scanning in a clinical trial of NPC patients (NCT03670342). These findings reveal a key role in EBV-associated NPC for SSTR2 in infection, imaging, targeted therapy and survival. Nasopharyngeal carcinoma (NPC) lacks effective diagnostic and therapeutic strategies, in particular at advanced stages. Here, the authors show that expression of the somatostatin receptor 2 is induced by Epstein-Barr virus in NPC and has a key role in the diagnosis, imaging, targeted therapies and prognosis of NPC