Development of in/outflow boundary conditions for MPM simulation of uniform and non-uniform open channel flows

This paper describes the development and application of inflow and outflow boundary conditions (BCs) for the material point method (MPM) in order to simulate fluid flow problems. This corresponds to velocity and pressure controlled BCs. Due to the coupled Lagrangian and Eulerian description of the fluid motion in MPM it is necessary to add and remove material points, with appropriate kinematic properties, to and from the computational domain. The newly-developed BCs have been used to simulate uniform open channel flow and the phenomenon of free overfall in open channels, which is transient conditions leading to non-uniform flow due to a sudden bed level drop. It is shown that the numerical results predict well the flow geometry including end depth ratio, pressure distribution and accelerations, therefore the velocities and displacements.Fundamental Research Funds for the Central Universities (2017B12214) of the Ministry of Education of China, NWO Project MPM-FLOW: Understanding flowslides in flood defences (Grant No. 13889

The Saliency of Gestural Misinformation in the Perception of a Violent Crime

This is the accepted manuscript version of the following article: Daniel J. gurney, Louise R. Ellis & Emily Vardn-Hynard, ‘The saliencey of gestural misinformation in the perception of a violent crime’, Psychology, Crime & Law, Vol. 22(7): 651-665, first published online 18 April 2016. The version of record is available online via doi: http://dx.doi.org/10.1080/1068316X.2016.1174860 Published by Taylor & Francis Online.Recent research has revealed that misinformation from gestures can influence eyewitness memory. However, while the effects of verbal influence have been shown to have major impacts on prosecution, gestural misinformation is yet to demonstrate misinformation effects to this extent. To investigate the salience of suggestions provided nonverbally, and how these compare to those made verbally, two experiments were conducted. In Experiment 1, participants watched footage of a crime scene and were presented with one of two types of gestures during questioning that suggested different interpretations of the crime. The results confirmed that the gestures influenced responses with participants altering their interpretation of the crime according to the information gestured to them. Experiment 2 built on this to investigate how comparable this gestural influence was to verbal influence. The results revealed that gestural misinformation caused participants to alter their interpretation of the crime and elicited the same effects as verbal misinformation. Additionally, participants were less likely to have felt misled from gestures as they were from speech. These results reveal new insights into the strength of gestural misinformation and show that, despite their subtle nature in communication, gestures can exert a powerful influence in eyewitness interviews.Peer reviewedFinal Accepted Versio

Integrating physical and economic data into experimental water accounts for the United States: Lessons and opportunities

Water management increasingly involves tradeoffs, making its accounting highly relevant in our interconnected world. Physical and economic data about water in many nations are becoming more widely integrated through application of the System of Environmental-Economic Accounts for Water (SEEA-Water), which enables the tracking of linkages between water and the economy. We present the first national and subnational SEEA-Water accounts for the United States. We compile accounts for water: (1) physical supply and use, (2) productivity, (3) quality, and (4) emissions for roughly the years 2000 to 2015. Total U.S. water use declined by 22% from 2000 to 2015, falling in 44 states though groundwater use increased in 21 states. Water-use reductions, combined with economic growth, led to increases in water productivity for the overall national economy (65%), mining (99%), and agriculture (68%). Surface-water quality trends were most evident at regional levels, and differed by waterquality constituent and region. This work provides (1) a baseline of recent historical water resource trends and their value in the U.S., and (2) a roadmap for the completion of future accounts for water, a critical ecosystem service. Our work also aids in the interpretation of ecosystem accounts in the context of long-term water resources trends.This work was conducted as a part of the “Accounting for U.S. Ecosystem Services at National and Subnational Scales” working group supported by the National Socio-Environmental Synthesis Center (SESYNC) under funding received from the National Science Foundation (grant DBI-1052875) and the U.S. Geological Survey (USGS) John Wesley Powell Center for Analysis and Synthesis (grant GX16EW00ECSV00). We thank members of the working group for constructive discussions of the scope and content of U.S. water accounts and reviews of this manuscript. We thank the following individuals for assistance with data access and interpretation: Cheryl Dieter, Carey Johnston, John Lovelace, Molly Maupin, Gary Rowe, and Lori Sprague. Support for Bagstad and Ancona’s time was provided by the USGS Land Change Science Program

Shark depredation: future directions in research and management

Shark depredation is a complex social-ecological issue that affects a range of fisheries worldwide. Increasing concern about the impacts of shark depredation, and how it intersects with the broader context of fisheries management, has driven recent research in this area, especially in Australia and the United States. This review synthesises these recent advances and provides strategic guidance for researchers aiming to characterise the occurrence of depredation, identify the shark species responsible, and test deterrent and management approaches to reduce its impacts. Specifically, the review covers the application of social science approaches, as well as advances in video camera and genetic methods for identifying depredating species. The practicalities and considerations for testing magnetic, electrical, and acoustic deterrent devices are discussed in light of recent research. Key concepts for the management of shark depredation are reviewed, with recommendations made to guide future research and policy development. Specific management responses to address shark depredation are lacking, and this review emphasizes that a “silver bullet” approach for mitigating depredation does not yet exist. Rather, future efforts to manage shark depredation must rely on a diverse range of integrated approaches involving those in the fishery (fishers, scientists and fishery managers), social scientists, educators, and other stakeholders

Macrophage-derived IL-1β and TNF-α regulate arginine metabolism in neuroblastoma

© 2018 American Association for Cancer Research. Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism. Targeting arginine metabolism, either by blocking cationic amino acid transporter 1 (CAT-1)-dependent arginine uptake in vitro or therapeutic depletion of arginine by pegylated recombinant arginase BCT-100, significantly delayed tumor development and prolonged murine survival. Tumor cells polarized infiltrating monocytes to an M1-macrophage phenotype, which released IL1b and TNFa in a RAC-alpha serine/threonine-protein kinase (AKT)-dependent manner. IL1b and TNFa established a feedback loop to upregulate ARG2 expression via p38 and extracellular regulated kinases 1/2 (ERK1/2) signaling in neuroblastoma and neural crest-derived cells. Proteomic analysis revealed that enrichment of IL1b and TNFa in stage IV human tumor microenvironments was associated with a worse prognosis. These data thus describe an immune-metabolic regulatory loop between tumor cells and infiltrating myeloid cells regulating ARG2, which can be clinically exploited

Biocatalytic conversion of lignin to aromatic dicarboxylic acids in Rhodococcus jostii RHA1 by re-routing aromatic degradation pathways

The heteropolymer lignin represents an untapped resource for production of renewable aromatic chemicals, if efficient depolymerisation methods can be developed. In this work, the metabolic pathways in Rhodococcus jostii RHA1 for degradation of aromatic lignin breakdown products are re-routed, in order to generate an aromatic dicarboxylic acid product that could be used for bioplastic synthesis. Protocatechuic acid is normally metabolised via ortho-cleavage to the β-keto-adipate pathway. Insertion of recombinant genes for protocatechuate 4,5-dioxygenase or protocatechuate 2,3-dioxygenase into R. jostii RHA1, followed by ammonia cyclisation of the extradiol cleavage products, generates pyridine 2,4-dicarboxylic acid or pyridine 2,5-dicarboxylic acid bioproducts in yields of 80–125 mg L−1 when grown on minimal media containing 1% wheat straw lignocellulose

The population approach to falls injury prevention in older people: findings of a two community trial

<p>Abstract</p> <p>Background</p> <p>There is a sound rationale for the population-based approach to falls injury prevention but there is currently insufficient evidence to advise governments and communities on how they can use population-based strategies to achieve desired reductions in the burden of falls-related injury. The aim of the study was to quantify the effectiveness of a streamlined (and thus potentially sustainable and cost-effective), population-based, multi-factorial falls injury prevention program for people over 60 years of age.</p> <p>Methods</p> <p>Population-based falls-prevention interventions were conducted at two geographically-defined and separate Australian sites: Wide Bay, Queensland, and Northern Rivers, NSW. Changes in the prevalence of key risk factors and changes in rates of injury outcomes within each community were compared before and after program implementation and changes in rates of injury outcomes in each community were also compared with the rates in their respective States.</p> <p>Results</p> <p>The interventions in neither community substantially decreased the rate of falls-related injury among people aged 60 years or older, although there was some evidence of reductions in occurrence of multiple falls reported by women. In addition, there was some indication of improvements in fall-related risk factors, but the magnitudes were generally modest.</p> <p>Conclusions</p> <p>The evidence suggests that low intensity population-based falls prevention programs may not be as effective as those that are intensively implemented.</p

Potential applications of nanotechnology in thermochemical conversion of microalgal biomass

The rapid decrease in fossil reserves has significantly increased the demand of renewable and sustainable energy fuel resources. Fluctuating fuel prices and significant greenhouse gas (GHG) emission levels have been key impediments associated with the production and utilization of nonrenewable fossil fuels. This has resulted in escalating interests to develop new and improve inexpensive carbon neutral energy technologies to meet future demands. Various process options to produce a variety of biofuels including biodiesel, bioethanol, biohydrogen, bio-oil, and biogas have been explored as an alternative to fossil fuels. The renewable, biodegradable, and nontoxic nature of biofuels make them appealing as alternative fuels. Biofuels can be produced from various renewable resources. Among these renewable resources, algae appear to be promising in delivering sustainable energy options. Algae have a high carbon dioxide (CO2) capturing efficiency, rapid growth rate, high biomass productivity, and the ability to grow in non-potable water. For algal biomass, the two main conversion pathways used to produce biofuel include biochemical and thermochemical conversions. Algal biofuel production is, however, challenged with process scalability for high conversion rates and high energy demands for biomass harvesting. This affects the viable achievement of industrial-scale bioprocess conversion under optimum economy. Although algal biofuels have the potential to provide a sustainable fuel for future, active research aimed at improving upstream and downstream technologies is critical. New technologies and improved systems focused on photobioreactor design, cultivation optimization, culture dewatering, and biofuel production are required to minimize the drawbacks associated with existing methods. Nanotechnology has the potential to address some of the upstream and downstream challenges associated with the development of algal biofuels. It can be applied to improve system design, cultivation, dewatering, biomass characterization, and biofuel conversion. This chapter discusses thermochemical conversion of microalgal biomass with recent advances in the application of nanotechnology to enhance the development of biofuels from algae. Nanotechnology has proven to improve the performance of existing technologies used in thermochemical treatment and conversion of biomass. The different bioprocess aspects, such as reactor design and operation, analytical techniques, and experimental validation of kinetic studies, to provide insights into the application of nanotechnology for enhanced algal biofuel production are addressed