Fascist di-visions of enjoyment and the perverse remainder : a psychoanalytic study

Under the shade of escalating violence and fundamentalism, our epoch's diffused aura of liberalism supposedly tolerates difference, by exorcising the evil phantasms of totalitarianism, in favour of a liberal and humane post-modem order. Consequently, behind contemporary versions of evil, one demonises modem 'fascists', 'totalitarian threats', and 'Hitlers'. As if not obscure enough, fascist evil has been equivocally linked with perversion. Considering this link a tenebrous enigma, my thesis suggests that psychoanalysis can successfully elucidate its problematic and feeble basis, by reappraising previous narratives from a number of different discourses that inscribe the liaison between fascism and perversion in their representational stage. In a first approach, the present study dissects texts as heterogeneous, as film, social theory, political philosophy, and psychoanalysis. This is to show that, despite the divergent speculative angle that each discourse espouses, perversion is a common exegetic thread, intertextually sewing their narratives. The objective of my criticism that goes through psychoanalysis, without, however, exempting it from this criticism, is to reveal that both fascism and perversion implicate the non-symbolisable kernel in politics, which becomes the source of their mystification. My thesis argues that the fascist does not take the same discursive position, as the pervert does, regarding this symbolic gap. The first is interested in domination, drawn from the superiority of his ideology's master signifier, whereas the latter is interested in excavating the emptiness of any master signifier and in constantly provoking prefabricated knowledge, similarly to the hysteric. Apart from the level of discourse, on the ethical level, I disengage the view that sees Sade and the Nazi officer, as emblematic figures of a Kantian ethical gesture. Considering the imaginary hypostasis of their ethical performance, I argue that personal interests, fantasies and desires, determine the austerity of their ethical duty. Yet, the fantasies of Sade and Nazism are incongruent, insomuch as they are organised by antithetical ideals. Finally, I develop a new rhetoric, de-pathologised and de-ideologised, regarding the structure of the so-called pervert, introducing new vocabularies and directions for psychoanalytic research that further distance the pervert, or whom I call the extra-ordinary subject, from fascist politics and, instead, expose his diachronic "fascist" isolation from the social edifice. This reveals the fruitful alternatives that can stem from a 'return to Freud cum Lacan, which supports a flexible on-going reformulation of psychoanalytic knowledge.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Fascist di-visions of enjoyment and the perverse remainder : a psychoanalytic study

Under the shade of escalating violence and fundamentalism, our epoch's diffused aura of liberalism supposedly tolerates difference, by exorcising the evil phantasms of totalitarianism, in favour of a liberal and humane post-modem order. Consequently, behind contemporary versions of evil, one demonises modem 'fascists', 'totalitarian threats', and 'Hitlers'. As if not obscure enough, fascist evil has been equivocally linked with perversion. Considering this link a tenebrous enigma, my thesis suggests that psychoanalysis can successfully elucidate its problematic and feeble basis, by reappraising previous narratives from a number of different discourses that inscribe the liaison between fascism and perversion in their representational stage. In a first approach, the present study dissects texts as heterogeneous, as film, social theory, political philosophy, and psychoanalysis. This is to show that, despite the divergent speculative angle that each discourse espouses, perversion is a common exegetic thread, intertextually sewing their narratives. The objective of my criticism that goes through psychoanalysis, without, however, exempting it from this criticism, is to reveal that both fascism and perversion implicate the non-symbolisable kernel in politics, which becomes the source of their mystification. My thesis argues that the fascist does not take the same discursive position, as the pervert does, regarding this symbolic gap. The first is interested in domination, drawn from the superiority of his ideology's master signifier, whereas the latter is interested in excavating the emptiness of any master signifier and in constantly provoking prefabricated knowledge, similarly to the hysteric. Apart from the level of discourse, on the ethical level, I disengage the view that sees Sade and the Nazi officer, as emblematic figures of a Kantian ethical gesture. Considering the imaginary hypostasis of their ethical performance, I argue that personal interests, fantasies and desires, determine the austerity of their ethical duty. Yet, the fantasies of Sade and Nazism are incongruent, insomuch as they are organised by antithetical ideals. Finally, I develop a new rhetoric, de-pathologised and de-ideologised, regarding the structure of the so-called pervert, introducing new vocabularies and directions for psychoanalytic research that further distance the pervert, or whom I call the extra-ordinary subject, from fascist politics and, instead, expose his diachronic "fascist" isolation from the social edifice. This reveals the fruitful alternatives that can stem from a 'return to Freud cum Lacan, which supports a flexible on-going reformulation of psychoanalytic knowledge.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Modelling Human Regulatory Variation in Mouse: Finding the Function in Genome-Wide Association Studies and Whole-Genome Sequencing

An increasing body of literature from genome-wide association studies and human whole-genome sequencing highlights the identification of large numbers of candidate regulatory variants of potential therapeutic interest in numerous diseases. Our relatively poor understanding of the functions of non-coding genomic sequence, and the slow and laborious process of experimental validation of the functional significance of human regulatory variants, limits our ability to fully benefit from this information in our efforts to comprehend human disease. Humanized mouse models (HuMMs), in which human genes are introduced into the mouse, suggest an approach to this problem. In the past, HuMMs have been used successfully to study human disease variants; e.g., the complex genetic condition arising from Down syndrome, common monogenic disorders such as Huntington disease and β-thalassemia, and cancer susceptibility genes such as BRCA1. In this commentary, we highlight a novel method for high-throughput single-copy site-specific generation of HuMMs entitled High-throughput Human Genes on the X Chromosome (HuGX). This method can be applied to most human genes for which a bacterial artificial chromosome (BAC) construct can be derived and a mouse-null allele exists. This strategy comprises (1) the use of recombineering technology to create a human variant–harbouring BAC, (2) knock-in of this BAC into the mouse genome using Hprt docking technology, and (3) allele comparison by interspecies complementation. We demonstrate the throughput of the HuGX method by generating a series of seven different alleles for the human NR2E1 gene at Hprt. In future challenges, we consider the current limitations of experimental approaches and call for a concerted effort by the genetics community, for both human and mouse, to solve the challenge of the functional analysis of human regulatory variation

Phenotypic comparison of four thalassemia model mice reconstructed from cryo-banked embryos

A major clinical feature of patients with thalassemia is growth retardation due to anemia, therefore, the hematological parameters, weanling weight and post-weanling weight of pups obtained from vitrifiedwarmed embryo transfers were studied for the first time in this report. Two-cell embryos of four transgenic (TG) thalassemic mouse lines (BKO, 654, E2, and E4) were produced by breeding four lines of TG thalassemic males to wild-type (WT) females (C57BL/6J) and were cryopreserved by vitrification in straws using 35% ethylene glycol. After transfer of vitrified-warmed embryos, hematological parameters, spleen index, weanling and post-weanling weight were determined in TG and WT viable pups. In the BKO and 654 mice significantly abnormal hematological parameters and spleen index were observed compared to WT, E2 and E4 mice. The weanling and post-weanling weights of BKO and 654 pups were significantly less than that of the age-matched WT pups. However, no significant differences in weanling and post-weanling weight were found between WT and E2-TG or E4-TG pups. In conclusion, the four transgenic mice lines produced from cryopreserved embryo transfer retain the phenotype of the natural breeding mice indicating that these banked embryos are appropriate for thalassemia model productions

DNA vaccines for bacterial infections

DNA vaccines are an exciting development in vaccine technology which may have a special role in preventing viral infections and as 'theracines' for cancer. Their use in preventing bacterial infections has, by comparison, been less well documented. While it is unlikely that traditional, highly successful and cheap vaccines for diseases such as diphtheria will be replaced by DNA vaccines, naked DNA may be particularly appropriate for preventing bacterial infections where cytotoxic T cells confer protection, or where a Th1 type T cell response mediates resistance. For example, DNA vaccines containing different mycobacterial antigens have been shown to inhibit overt infections by Mycobacterium tuberculosis in rodent models. The use of DNA vaccines in bacterial infections may be complicated by fundamental differences between prokaryotic and eukaryotic genes and gene products, including mRNA stability, codon bias, secondary structures surrounding native start sequences and glycosylation. These problems can be solved by re-synthesis of bacterial genes to produce 'new' sequences which are more highly expressed by eukaryotic cells