Regioselective Reactions of Highly Substituted Arynes

The fully regioselective reactivity of four new highly substituted silyl aryl triflate aryne precursors in aryne acyl-alkylation, acyl-alkylation/condensation, and heteroannulation reactions is reported. The application of these more complex arynes provides access to diverse natural product scaffolds and obviates late-stage functionalization of aromatic rings

Astrophysical parameters of 14 open clusters projected close to the Galactic plane

Astrophysical parameters (\textit{age, reddening, distance, core and cluster radii}) of 14 open clusters (OCs) projected close to the Galactic plane are derived with 2MASS photometry. The OCs are Be 63, Be 84, Cz 6, Cz 7, Cz 12, Ru 141, Ru 144, Ru 172, FSR 101, FSR 1430, FSR 1471, FSR 162, FSR 178 and FSR 198. The OCs Be 63, Be 84, Ru 141, Ru 144, and Ru 172 are studied in more detail than in previous works, while the others have astrophysical parameters derived for the first time. The open clusters of the sample are located at $d_\odot=1.6-7.1$ kpc from the Sun and at Galactocentric distances $5.5-11.8$ kpc, with age in the range 10 Myr to 1.5 Gyr and reddening $E(B-V)$ in the range $0.19-2.56$ mag. The core and cluster radii are in the range $0.27-1.88$ pc and $2.2-11.27$ pc, respectively. Cz 6 and FSR 198 are the youngest OCs of this sample, with a population of pre-main sequence (PMS) stars, while FSR 178 is the oldest cluster.Comment: 11 pages, 14 figures - accepted by A&

Global survey of star clusters in the Milky Way I. The pipeline and fundamental parameters in the second quadrant

Aims: On the basis of the PPMXL star catalogue we performed a survey of star clusters in the second quadrant of the Milky Way. Methods: From the PPMXL catalogue of positions and proper motions we took the subset of stars with near-infrared photometry from 2MASS and added the remaining 2MASS stars without proper motions (called 2MAst, i.e. 2MASS with astrometry). We developed a data-processing pipeline including interactive human control of a standardised set of multi-dimensional diagrams to determine kinematic and photometric membership probabilities for stars in a cluster region. The pipeline simultaneously produced the astrophysical parameters of a cluster. From literature we compiled a target list of presently known open and globular clusters, cluster candidates, associations, and moving groups. From established member stars we derived spatial parameters (coordinates of centres and radii of the main morphological parts of clusters) and cluster kinematics (average proper motions and sometimes radial velocities). For distance, reddening, and age determination we used specific sets of theoretical isochrones. Tidal parameters were obtained by a fit of three-parameter King profiles to the observed density distributions of members. Results: We investigated all 871 objects in the 2nd Galactic quadrant, of which we successfully treated 642 open clusters, 2 globular clusters, and 8 stellar associations. The remaining 219 objects (24%) were recognised by us to be nonexistent clusters, duplicate entries, or clusters too faint for 2MAst. We found that our sample is complete in the 2nd quadrant up to a distance of 2 kpc, where the average surface density is 94 clusters per kpc$^{2}$. Compared with literature values we found good agreement in spatial and kinematic data, as well as for optical distances and reddening. Small, but systematic offsets were detected in the age determination.Comment: published in Astronomy and Astrophysics, 10 pages, 7 figures (plus 3 pages of appendices incl. 2 more figures), catalogues will be available at the CDS, all the machine-readable online data described in appendices A, B, and C are also available at: http://www.aip.de/People/rdscholz/kharchenko_etal_2012

Towards a census of the Galactic anticentre star clusters: colour-magnitude diagram and structural analyses of a sample of 50 objects

In this work we investigate the nature of 50 overdensities from the catalogue of Froebrich, Scholz, and Raftery (FSR) projected towards the Galactic anticentre, in the sector 160{\deg} \leq \ell \leq 200{\deg}. The sample contains candidates with |b| \leq 20{\deg} classified by FSR as probable open cluster (OC) and labelled with quality flags 2 and 3. Our main purpose is to determine the nature of these OC candidates and the fraction of these objects that are unknown OCs, as well as to derive astrophysical parameters (age, reddening, distance, core and cluster radii) for the clusters and to investigate the relationship among parameters. The analysis is based on 2MASS J, (J-H), and (J-Ks) colour-magnitude diagrams (CMDs), and stellar radial density profiles (RDPs) built with decontamination tools. The tools are a field star decontamination algorithm, used to uncover the cluster's intrinsic CMD morphology, and colour-magnitude filters to isolate stars with a high probability of being cluster members. Out of the 50 objects, 16 (32%) are star clusters. We show that 9 (18%) overdensities are new OCs (FSR 735, FSR 807, FSR 812, FSR 826, FSR 852, FSR 904, FSR 941, FSR 953, and FSR 955) and 7 (14%) are previously studied or catalogued OCs (KKC1, FSR 795, Cz 22, FSR 828, FSR 856, Cz 24, and NGC 2234). These are OCs with ages in the range 5 Myr to 1 Gyr, at distances from the Sun 1.28 \precnapprox d_Sun(kpc) \precnapprox 5.78 and Galactocentric distances 8.5 R_GC(kpc) \precnapprox 12.9. We also derive parameters for the previously analysed OCs Cz 22 and NGC 2234. Five (10%) candidates are classified as uncertain cases, and the remaining objects are probable field fluctuations.Comment: 14 pages, 15 figure

Population analysis of open clusters: radii and mass segregation

Aims: Based on our well-determined sample of open clusters in the all-sky catalogue ASCC-2.5 we derive new linear sizes of some 600 clusters, and investigate the effect of mass segregation of stars in open clusters. Methods: Using statistical methods, we study the distribution of linear sizes as a function of spatial position and cluster age. We also examine statistically the distribution of stars of different masses within clusters as a function of the cluster age. Results: No significant dependence of the cluster size on location in the Galaxy is detected for younger clusters (< 200 Myr), whereas older clusters inside the solar orbit turned out to be, on average, smaller than outside. Also, small old clusters are preferentially found close to the Galactic plane, whereas larger ones more frequently live farther away from the plane and at larger Galactocentric distances. For clusters with (V - M_V) < 10.5, a clear dependence of the apparent radius on age has been detected: the cluster radii decrease by a factor of about 2 from an age of 10 Myr to an age of 1 Gyr. A detailed analysis shows that this observed effect can be explained by mass segregation and does not necessarily reflect a real decrease of cluster radii. We found evidence for the latter for the majority of clusters older than 30 Myr. Among the youngest clusters (between 5 and 30 Myr), there are some clusters with a significant grade of mass segregation, whereas some others show no segregation at all. At a cluster age between 50 and 100 Myrs, the distribution of stars of different masses becomes more regular over cluster area. In older clusters the evolution of the massive stars is the most prominent effect we observe.Comment: 14 pages, 12 figures, accepted for publication in Astronomy & Astrophysic

Towards absolute scales of radii and masses of open clusters

Aims: In this paper we derive tidal radii and masses of open clusters in the nearest kiloparsecs around the Sun. Methods: For each cluster, the mass is estimated from tidal radii determined from a fitting of three-parametric King's profiles to the observed integrated density distribution. Different samples of members are investigated. Results: For 236 open clusters, all contained in the catalogue ASCC-2.5, we obtain core and tidal radii, as well as tidal masses. The distributions of the core and tidal radii peak at about 1.5 pc and 7 - 10 pc, respectively. A typical relative error of the core radius lies between 15% and 50%, whereas, for the majority of clusters, the tidal radius was determined with a relative accuracy better than 20%. Most of the clusters have tidal masses between 50 and 1000 $m_\odot$, and for about half of the clusters, the masses were obtained with a relative error better than 50%.Comment: 11 pages, 7 figures, accepted for publication in Astronomy & Astrophysic

Concise total syntheses of (–)-jorunnamycin A and (–)-jorumycin enabled by asymmetric catalysis

The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong gram-positive and -negative antibiotic character. Synthetic strategies toward these complex polycyclic compounds have relied heavily on electrophilic aromatic chemistry, such as the Pictet-Spengler reaction, that mimics their biosynthetic pathways. Herein we report an approach to two bis-THIQ natural products, jorunnamycin A and jorumycin, that instead harnesses the power of modern transition-metal catalysis for the three major bond-forming events and proceeds with high efficiency (15 and 16 steps, respectively). By breaking from biomimicry, this strategy allows for the preparation of a more diverse set of non-natural analogs

Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence

The mediobasal hypothalamus (MBH; arcuate nucleus of the hypothalamus [ARH] and median eminence [ME]) is a key nutrient sensing site for the production of the complex homeostatic feedback responses required for the maintenance of energy balance. Here, we show that refeeding after an overnight fast rapidly triggers proliferation and differentiation of oligodendrocyte progenitors, leading to the production of new oligodendrocytes in the ME specifically. During this nutritional paradigm, ME perineuronal nets (PNNs), emerging regulators of ARH metabolic functions, are rapidly remodeled, and this process requires myelin regulatory factor (Myrf) in oligodendrocyte progenitors. In genetically obese ob/ob mice, nutritional regulations of ME oligodendrocyte differentiation and PNN remodeling are blunted, and enzymatic digestion of local PNN increases food intake and weight gain. We conclude that MBH PNNs are required for the maintenance of energy balance in lean mice and are remodeled in the adult ME by the nutritional control of oligodendrocyte differentiation