414 research outputs found
Recurrent early filter clotting during continuous veno-venous hemodialysis with regional citrate anticoagulation is linked to systemic thrombin generation and heparin induced thrombocytopenia type II: a retrospective analysis
OBJECTIVE: Regional citrate anticoagulation (RCA) for continuous renal replacement therapy (CRRT) is widely used and leads to an excellent clottingfree filter survival. Despite strict adherence to protocols, in some cases recurrent early filter-clotting occurs. The aim of this observational study was to evaluate the underlying causes and the efficacy of interventions in patients with early recurrent filter-clotting during RCA. METHODS: In a retrospective analysis of a cohort of 1183 patients treated with RCA-CRRT we detected 12 patients with early filter-clotting unrelated to protocol violation or any obvious technical or medical reason. RESULTS: All patients were systemically anticoagulated with low molecular weight or unfractionated heparin for at least 24h before initiation of Continuous Veno-Venous Hemodialysis with RCA (RCA-CVVHD). During RCA, all postfilter ionized calcium concentrations were in the target range (mean 0.33±0.05 mmol/L). At the time of the first clotting event, thrombocyte counts were 168±66/ nL. After the clotting events, the systemic anticoagulation was switched to argatroban in all patients. With systemic anticoagulation using argatroban filter lifetime of RCA-CVVHD increased significantly (p<0.001) and clotting-events decreased from 0.61 to 0.10 per 24h. All patients were tested for HIT and 5/12 (42%) had a positive test for hep-PF4-antibodies. Application of argatroban significantly reduced early filter-clotting both in HIT-positive patients as well as in HIT-negative patients. At the time of the first clotting event, no patient had clinical signs of thrombosis or thromboembolism. However, during follow up a thromboembolic event occurred in three patients. CONCLUSION: In patients with recurrent early filter-clotting despite strict adherence to the citrate protocol undetected HIT or other causes of thrombin activation may be present. Therefore, patients with recurrent early filter clotting in RCA-CVVHD should be screened for HIT or other conditions that may activate thrombin. A significant improvement of filter run-time can be achieved by systemic administration of a thrombin inhibitor both in patients with and without HIT
Search for the Decay
We have searched for the decay of the tau lepton into seven charged particles
and zero or one pi0. The data used in the search were collected with the CLEO
II detector at the Cornell Electron Storage Ring (CESR) and correspond to an
integrated luminosity of 4.61 fb^(-1). No evidence for a signal is found.
Assuming all the charged particles are pions, we set an upper limit on the
branching fraction, B(tau- -> 4pi- 3pi+ (pi0) nu_tau) < 2.4 x 10^(-6) at the
90% confidence level. This limit represents a significant improvement over the
previous limit.Comment: 9 page postscript file, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
Flavor-Specific Inclusive B Decays to Charm
We have measured the branching fractions for B -> D_bar X, B -> D X, and B ->
D_bar X \ell^+ \nu, where ``B'' is an average over B^0 and B^+, ``D'' is a sum
over D^0 and D^+, and``D_bar'' is a sum over D^0_bar and D^-. From these
results and some previously measured branching fractions, we obtain Br(b -> c
c_bar s) = (21.9 3.7)%, Br(b -> s g) K^-
\pi^+) = (3.69 0.20)%. Implications for the ``B semileptonic decay
problem'' (measured branching fraction being below theoretical expectations)
are discussed. The increase in the value of Br(b -> c c_bar s) due to eliminates 40% of the discrepancy.Comment: 12 page postscript file, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
Measurement of the Partila Width and Form Factor Parameters
We have studied the decay , where . From a fit to the differential decay rate we measure the
rate normalization and form factor slope
, and, using measured values of , find . The resulting branching
fractions are and .
The form factor parameters are in agreement with those measured in decays, as predicted by heavy quark effective theory.Comment: 11 pages, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
Measurement of using Partila Reconstruction of
We present a measurement of the absolute branching fraction for using the reconstruction of the decay chain , where only the lepton and the low-momentum pion from
the are detected. With data collected by the CLEO II detector at the
Cornell Electron Storage Ring, we have determined .Comment: 10 page postscript file, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
Limit on the Two-Photon Production of the Glueball Candidate at CLEO
We use the CLEO detector at the Cornell electron-positron storage ring, CESR,
to search for the two-photon production of the glueball candidate f_J(2220) in
its decay to K_s K_s. We present a restrictive upper limit on the product of
the two-photon partial width and the K_s K_s branching fraction. We use this
limit to calculate a lower limit on the stickiness, which is a measure of the
two-gluon coupling relative to the two-photon coupling. This limit on
stickiness indicates that the f_J(2220) has substantial glueball content.Comment: 9 page postscript file, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
Investigation of Semileptonic Meson Decay to P-Wave Charm Mesons
We have studied semileptonic meson decays with a P-wave charm meson in
the final state using 3.29 x 10^6 B\bar{B} events collected by the CLEO~II
detector at the Cornell Electron-positron Storage Ring. We find a value for the
exclusive semileptonic product branching fraction: Br(B^- -> D_1^0 l^-
\bar{\nu}) x Br(D_1^0 -> D^{*+}\pi^-) = (0.373 \pm 0.085 \pm 0.052 \pm 0.024)%
and an upper limit for Br(B^- -> D_2^{*0} l^- \bar{\nu}) x Br(D_2^{*0} ->
D^{*+}\pi^-) < 0.16%$ (90% C.L.). These results indicate that at least 20% of
the total B^- semileptonic rate is unaccounted for by the observed exclusive
decays, B^- -> D^0 l^- \bar{\nu}, B^- -> D^{*0} l^- \bar{\nu}, B^- -> D_1^0 l^-
\bar{\nu}, and B^- -> D_2^{*0} l^- \bar{\nu}.Comment: 10 page postscript file, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
Determination of the Michel Parameters and the tau Neutrino Helicity in tau Decay
Using the CLEO II detector at the storage ring CESR, we have
determined the Michel parameters , , and in decay as well as the tau neutrino helicity parameter
in decay. From a data sample of
tau pairs produced at , using events of
the topology and , and the determined sign of , the combined
result of the three samples is: , , , and
. The results are in agreement with
the Standard Model V-A interaction.Comment: 18 page postscript file, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
Tau Neutrino Helicity from Energy Correlations
We report a measurement of the magnitude of the tau neutrino helicity from
tau-pair events taken with the CLEO detector at the CESR electron-positron
storage ring. Events in which each tau undergoes the decay tau -> h nu, with h
a charged pion or kaon, are analyzed for energy correlations between the
daughter hadrons, yielding |xi| = 2*|h_nu| = 1.03 +/- 0.06 +/- 0.04, with the
first error statistical and the second systematic.Comment: 11 pages, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
Measurement of the Branching Ratios for the Decays of , and
Using a data sample with integrated luminosity of about 3.9 fb^{-1} collected
in e+ e- annihilation with the CLEO-II detector at the Cornell Electron Storage
Ring, we have measured the branching ratios for the decay modes Ds -> (eta,
eta') pi and Ds -> (eta, eta') rho relative to Ds -> phi pi. These decay modes
are among the most common hadronic decays of the Ds's and can be related by
factorization to the semileptonic decays Ds -> (eta,eta') l nu. The results
obtained are compared with previous CLEO results and with the branching ratios
measured for the related semileptonic decays. We also report results on the
Cabibbo-suppressed decays of the D+ to the same final states.Comment: 18 page postscript file, postscript file also available through
http://w4.lns.cornell.edu/public/CLN
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