5,814 research outputs found
Microstructure Effects on Daily Return Volatility in Financial Markets
We simulate a series of daily returns from intraday price movements initiated
by microstructure elements. Significant evidence is found that daily returns
and daily return volatility exhibit first order autocorrelation, but trading
volume and daily return volatility are not correlated, while intraday
volatility is. We also consider GARCH effects in daily return series and show
that estimates using daily returns are biased from the influence of the level
of prices. Using daily price changes instead, we find evidence of a significant
GARCH component. These results suggest that microstructure elements have a
considerable influence on the return generating process.Comment: 15 pages, as presented at the Complexity Workshop in Aix-en-Provenc
Learning to Generate Images with Perceptual Similarity Metrics
Deep networks are increasingly being applied to problems involving image
synthesis, e.g., generating images from textual descriptions and reconstructing
an input image from a compact representation. Supervised training of
image-synthesis networks typically uses a pixel-wise loss (PL) to indicate the
mismatch between a generated image and its corresponding target image. We
propose instead to use a loss function that is better calibrated to human
perceptual judgments of image quality: the multiscale structural-similarity
score (MS-SSIM). Because MS-SSIM is differentiable, it is easily incorporated
into gradient-descent learning. We compare the consequences of using MS-SSIM
versus PL loss on training deterministic and stochastic autoencoders. For three
different architectures, we collected human judgments of the quality of image
reconstructions. Observers reliably prefer images synthesized by
MS-SSIM-optimized models over those synthesized by PL-optimized models, for two
distinct PL measures ( and distances). We also explore the
effect of training objective on image encoding and analyze conditions under
which perceptually-optimized representations yield better performance on image
classification. Finally, we demonstrate the superiority of
perceptually-optimized networks for super-resolution imaging. Just as computer
vision has advanced through the use of convolutional architectures that mimic
the structure of the mammalian visual system, we argue that significant
additional advances can be made in modeling images through the use of training
objectives that are well aligned to characteristics of human perception
Validation of magnetophonon spectroscopy as a tool for analyzing hot-electron effects in devices
It is shown that very high precision hot-electron magnetophonon experiments made on n+n−n+-GaAs sandwich device structures which are customized for magnetoresistance measurements can be very accurately modeled by a new Monte Carlo technique. The latter takes account of the Landau quantization and device architecture as well as material parameters. It is proposed that this combination of experiment and modeling yields a quantitative tool for the direct analysis of spatially localized very nonequilibrium electron distributions in small devices and low dimensional structures
First Passage Properties of the Erdos-Renyi Random Graph
We study the mean time for a random walk to traverse between two arbitrary
sites of the Erdos-Renyi random graph. We develop an effective medium
approximation that predicts that the mean first-passage time between pairs of
nodes, as well as all moments of this first-passage time, are insensitive to
the fraction p of occupied links. This prediction qualitatively agrees with
numerical simulations away from the percolation threshold. Near the percolation
threshold, the statistically meaningful quantity is the mean transit rate,
namely, the inverse of the first-passage time. This rate varies
non-monotonically with p near the percolation transition. Much of this behavior
can be understood by simple heuristic arguments.Comment: 10 pages, 9 figures, 2-column revtex4 forma
One-carbon metabolism in cancer
Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, and these pathways support the high proliferative rate of cancer cells. As such, anti-folates, drugs that target one-carbon metabolism, have long been used in the treatment of cancer. Amino acids, such as serine are a major one-carbon source, and cancer cells are particularly susceptible to deprivation of one-carbon units by serine restriction or inhibition of de novo serine synthesis. Recent work has also begun to decipher the specific pathways and sub-cellular compartments that are important for one-carbon metabolism in cancer cells. In this review we summarise the historical understanding of one-carbon metabolism in cancer, describe the recent findings regarding the generation and usage of one-carbon units and explore possible future therapeutics that could exploit the dependency of cancer cells on one-carbon metabolism
Embedded Stellar Clusters in the W3/W4/W5 Molecular Cloud Complex
We analyze the embedded stellar content in the vicinity of the W3/W4/W5 HII
regions using the FCRAO Outer Galaxy 12CO(J=1-0) Survey, the IRAS Point Source
Catalog, published radio continuum surveys, and new near-infrared and molecular
line observations. Thirty-four IRAS Point Sources are identified that have
far-infrared colors characteristic of embedded star forming regions, and we
have obtained K' mosaics and 13CO(J=1-0) maps for 32 of them. Ten of the IRAS
sources are associated with an OB star and 19 with a stellar cluster, although
three OB stars are not identified with a cluster. Half of the embedded stellar
population identified in the K' images is found in just the 5 richest clusters,
and 61% is contained in IRAS sources associated with an embedded OB star. Thus
rich clusters around OB stars contribute substantially to the stellar
population currently forming in the W3/W4/W5 region. Approximately 39% of the
cluster population is embedded in small clouds with an average mass of ~130 Mo
that are located as far as 100 pc from the W3/W4/W5 cloud complex. We speculate
that these small clouds are fragments of a cloud complex dispersed by previous
episodes of massive star formation. Finally, we find that 4 of the 5 known
embedded massive star forming sites in the W3 molecular cloud are found along
the interface with the W4 HII region despite the fact that most of the
molecular mass is contained in the interior regions of the cloud. These
observations are consistent with the classical notion that the W4 HII region
has triggered massive star formation along the eastern edge of the W3 molecular
cloud.Comment: to appear in ApJS, see http://astro.caltech.edu/~jmc/papers/w
Water Abundance in Molecular Cloud Cores
We present Submillimeter Wave Astronomy Satellite (SWAS) observations of the
1_{10}-1_{01} transition of ortho-water at 557 GHz toward 12 molecular cloud
cores. The water emission was detected in NGC 7538, Rho Oph A, NGC 2024, CRL
2591, W3, W3(OH), Mon R2, and W33, and was not detected in TMC-1, L134N, and
B335. We also present a small map of the water emission in S140. Observations
of the H_2^{18}O line were obtained toward S140 and NGC 7538, but no emission
was detected. The abundance of ortho-water relative to H_2 in the giant
molecular cloud cores was found to vary between 6x10^{-10} and 1x10^{-8}. Five
of the cloud cores in our sample have previous water detections; however, in
all cases the emission is thought to arise from hot cores with small angular
extents. The water abundance estimated for the hot core gas is at least 100
times larger than in the gas probed by SWAS. The most stringent upper limit on
the ortho-water abundance in dark clouds is provided in TMC-1, where the
3-sigma upper limit on the ortho-water fractional abundance is 7x10^{-8}.Comment: 5 pages, 3 Postscript figures, uses aastex.cls, emulateapj5.sty
(included), and apjfonts.sty (included
A Training Framework and Follow-Up Observations for Multiculturally Inclusive Teaching: Is Believing That We are Emphasizing Diversity Enough?
The authors present a theoretically and empirically grounded training for multiculturally inclusive teaching for new instructors. After implementing this training, qualitative data were gathered from instructors to identify their experience of the training and concerns related to incorporating issues of diversity into their classrooms (Study 1). At the end of the semester immediately following the training, quantitative data were gathered from instructors and their students to examine the interaction between students’ and instructors’ perceived diversity emphasis (Study 2). When allowed to choose the extent to which they incorporated issues of diversity in their classes, the instructors differentially reported emphasizing diversity in class. In addition, results from multi-level linear modeling analyses demonstrated that instructors’ reported emphasis on diversity in the classroom did not predict students’ perceptions of the inclusion of issues of diversity. The authors discuss implications for the development of multiculturally supportive programs of learning at universities
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