Fermi Detection of the Pulsar Wind Nebula HESS J1640-465

We present observations of HESS J1640-465 with the Fermi-LAT. The source is detected with high confidence as an emitter of high-energy gamma-rays. The spectrum lacks any evidence for the characteristic cutoff associated with emission from pulsars, indicating that the emission arises primarily from the pulsar wind nebula. Broadband modeling implies an evolved nebula with a low magnetic field resulting in a high gamma-ray to X-ray flux ratio. The Fermi emission exceeds predictions of the broadband model, and has a steeper spectrum, possibly resulting from a distinct excess of low energy electrons similar to what is inferred for both the Vela X and Crab pulsar wind nebulae.Comment: 6 pages, 5 figures, accepted for publication in Ap

Supernova Remnant Kes 17: Efficient Cosmic Ray Accelerator inside a Molecular Cloud

Supernova remnant Kes 17 (SNR G304.6+0.1) is one of a few but growing number of remnants detected across the electromagnetic spectrum. In this paper, we analyze recent radio, X-ray, and gamma-ray observations of this object, determining that efficient cosmic ray acceleration is required to explain its broadband non-thermal spectrum. These observations also suggest that Kes 17 is expanding inside a molecular cloud, though our determination of its age depends on whether thermal conduction or clump evaporation is primarily responsible for its center-filled thermal X-ray morphology. Evidence for efficient cosmic ray acceleration in Kes 17 supports recent theoretical work that the strong magnetic field, turbulence, and clumpy nature of molecular clouds enhances cosmic ray production in supernova remnants. While additional observations are needed to confirm this interpretation, further study of Kes 17 is important for understanding how cosmic rays are accelerated in supernova remnants.Comment: 13 pages, 6 figures, 4 table

A Dynamical Model for the Evolution of a Pulsar Wind Nebula inside a Non-Radiative Supernova Remnant

A pulsar wind nebula inside a supernova remnant provides a unique insight into the properties of the central neutron star, the relativistic wind powered by its loss of rotational energy, its progenitor supernova, and the surrounding environment. In this paper, we present a new semi-analytic model for the evolution of such a pulsar wind nebula which couples the dynamical and radiative evolution of the pulsar wind nebulae, traces the evolution of the pulsar wind nebulae throughout the lifetime of the supernova remnant produced by the progenitor explosion, and predicts both the dynamical and radiative properties of the pulsar wind nebula during this period. We also discuss the expected evolution for a particular set of these parameters, and show it reproduces many puzzling features of known young and old pulsar wind nebulae. The model also predicts spectral features during different phases of its evolution detectable with new radio and gamma-ray observing facilities. Finally, this model has implications for determining if pulsar wind nebulae can explain the recent measurements of the cosmic ray positron fraction by PAMELA and the cosmic ray lepton spectrum by ATIC and HESS.Comment: To be submitted to the Astrophysical Journal. Figures are included as GIF files, and a version containing the high-resolution figures is available http://cosmo.nyu.edu/~jg168/pwn/ms.pd

Intrinsic expression of host genes and intronic miRNAs in prostate carcinoma cells

Abstract Background Recent data show aberrant and altered expression of regulatory noncoding micro (mi) RNAs in prostate cancer (PCa). A large number of miRNAs are encoded in organized intronic clusters within many protein coding genes. While expression profiling studies of miRNAs are common place, little is known about the host gene and their resident miRNAs coordinated expression in PCa cells. Furthermore, whether expression of a subset of miRNAs is distinct in androgen-responsive and androgen-independent cells is not clear. Here we have examined the expression of mature miRNAs of miR 17–92, miR 106b-25 and miR 23b-24 clusters along with their host genes C13orf25, MCM7 and AMPO respectively in PCa cell lines. Results The expression profiling of miRNAs and host genes was performed in androgen-sensitive MDA PCa 2b and LNCaP as well as in androgen-refractory PC-3 and DU 145 cell culture models of PCa. No significant correlation between the miRNA expression and the intrinsic hormone-responsive property of PCa cells was observed. Androgen-sensitive MDA PCa 2b cells exhibited the highest level of expression of most miRNAs studied in this report. We found significant expression variations between host genes and their resident miRNAs. The expressions of C13orf25 and miR 17–92 cluster as well as MCM7 and miR 106b-25 cluster did not reveal statistically significant correlation, thus suggesting that host genes and resident miRNAs may be expressed independent of each other. Conclusion Our results suggest that miRNA expression profiles may not predict intrinsic hormone-sensitive environment of PCa cells. More importantly, our data indicate the possibility of additional novel mechanisms for intronic miRNA processing in PCa cells.</p