A KINEMATIC DESCRIPTION OF THE POST PUBESCENT WINDMILL SOFTBALL PITCHING MOTION

The purpose of this study was to describe the kinematics of the windmill softball pitch. Throughout the first three phases of the movement, both the pelvis and the trunk were rotated to a closed position while the throwing shoulder was flexed and externally rotated, and the throwing elbow was flexed. During the latter stages of the movement, the pelvis and torso opened up to face the plate, the throwing shoulder moved through an arc of hyperextension and was internally rotated while the throwing elbow extended. The kinematics identified may contribute to overuse injuries commonly reported by post pubescent softball pitchers. However, due to the limited data describing the windmill softball pitch, addition research is needed

Conformational Plasticity of proNGF

Nerve Growth Factor is an essential protein that supports neuronal survival during development and influences neuronal function throughout adulthood, both in the central and peripheral nervous system. The unprocessed precursor of NGF, proNGF, seems to be endowed with biological functions distinct from those of the mature protein, such as chaperone-like activities and apoptotic and/or neurotrophic properties. We have previously suggested, based on Small Angle X-ray Scattering data, that recombinant murine proNGF has features typical of an intrinsically unfolded protein. Using complementary biophysical techniques, we show here new evidence that clarifies and widens this hypothesis through a detailed comparison of the structural properties of NGF and proNGF. Our data provide direct information about the dynamic properties of the pro-peptide and indicate that proNGF assumes in solution a compact globular conformation. The N-terminal pro-peptide extension influences the chemical environment of the mature protein and protects the protein from proteolytic digestion. Accordingly, we observe that unfolding of proNGF involves a two-steps mechanism. The distinct structural properties of proNGF as compared to NGF agree with and rationalise a different functional role of the precursor

Variants in the fetal genome near FLT1 are associated with risk of preeclampsia.

: Preeclampsia, which affects approximately 5% of pregnancies, is a leading cause of maternal and perinatal death. The causes of preeclampsia remain unclear, but there is evidence for inherited susceptibility. Genome-wide association studies (GWAS) have not identified maternal sequence variants of genome-wide significance that replicate in independent data sets. We report the first GWAS of offspring from preeclamptic pregnancies and discovery of the first genome-wide significant susceptibility locus (rs4769613; P = 5.4 × 10(-11)) in 4,380 cases and 310,238 controls. This locus is near the FLT1 gene encoding Fms-like tyrosine kinase 1, providing biological support, as a placental isoform of this protein (sFlt-1) is implicated in the pathology of preeclampsia. The association was strongest in offspring from pregnancies in which preeclampsia developed during late gestation and offspring birth weights exceeded the tenth centile. An additional nearby variant, rs12050029, associated with preeclampsia independently of rs4769613. The newly discovered locus may enhance understanding of the pathophysiology of preeclampsia and its subtypes.<br/

The Influence of Manga on the Graphic Novel

This material has been published in The Cambridge History of the Graphic Novel edited by Jan Baetens, Hugo Frey, Stephen E. Tabachnick. This version is free to view and download for personal use only. Not for re-distribution, re-sale or use in derivative works. © Cambridge University PressProviding a range of cogent examples, this chapter describes the influences of the Manga genre of comics strip on the Graphic Novel genre, over the last 35 years, considering the functions of domestication, foreignisation and transmedia on readers, markets and forms

Air quality indexing

In an attempt to meet the public's needs for information on air quality a variety of indexes have been developed and they continue to evolve. To show the complexity and the diversity of such indices, a variety of current air quality indices are described here and compared in regard to their performance and ability to deliver quality information. A number of characteristics seem desirable for an index: consistency, simplicity, versatility and flexibility. In terms of their ongoing development, an AQI also needs to be useful for forecasting, and the method of calculation needs to be sufficiently flexible to allow for pollutants to be added or subtracted as changes to their health impact are revealed. However, much progress is still to be made, mainly through more careful consideration of the combined impact of multiple pollutants, consideration of low level exposure, and with more timely transfer of usable information to the public