1,109 research outputs found
Magnetization of small lead particles
The magnetization of an ensemble of isolated lead grains of sizes ranging
from below 6 nm to 1000 nm is measured. A sharp disappearance of Meissner
effect with lowering of the grain size is observed for the smaller grains. This
is a direct observation by magnetization measurement of the occurrence of a
critical particle size for superconductivity, which is consistent with
Anderson's criterion.Comment: 7 pages, 5 figures, Submitted to PR
Metatarsophalangeal joint pain in psoriatic arthritis: a cross-sectional study
Methods. Thirty-four consecutive patients with PsA (mean age 45.3 years, 65% female, mean disease duration 9.9 years) and 22 control participants (mean age 37.9 years, 64% female) underwent clinical and US examination to determine the presence of pain, swelling, synovitis, erosions, effusions and submetatarsal bursae at the MTP joints. Mean barefoot peak plantar pressures were determined at each MTP joint. Levels of pain, US-determined pathology and peak pressures were compared between groups. Binary logistic regression was used to identify demographic, clinical examination-derived, US-derived and plantar pressure predictors of pain at the MTP joints in the PsA group.
Results. The presence of pain, deformity, synovitis, erosions (P < 0.001) and submetatarsal bursae and peak plantar pressure at MTP 3 (P < 0.05) were significantly higher in the PsA group. MTP joint pain in PsA was independently predicted by high BMI, female gender and the presence of joint subluxation, synovitis and erosion.
Conclusion. These results suggest local inflammatory and structural factors, together with systemic factors (gender, BMI), are predominantly responsible for painful MTP joints in PsA, with no clear role for plantar pressure characteristics
Constraints on narrow exotic states from K+p and K0_Lp scattering data
We consider the effect of exotic S=+1 resonances Theta+ and Theta++ on K+p
elastic scattering data (total cross section) and the process K0_Lp-->K0_Sp.
Data near the observed Theta+(1540) are examined for evidence of additional
states. The width limit for a Theta++ state is reconsidered and shown to be
much less than 1 MeV.Comment: 4 pages, 3 eps figures; minor corrections, one fig adde
Antiphospholipid autoantibodies as blood biomarkers for detection of early stage Alzheimer's disease
A robust blood biomarker is urgently needed to facilitate early prognosis for those at risk for Alzheimer's disease (AD). Redox reactive autoantibodies (R-RAAs) represent a novel family of antibodies detectable only after exposure of cerebrospinal fluid (CSF), serum, plasma or immunoglobulin fractions to oxidizing agents. We have previously reported that R-RAA antiphospholipid antibodies (aPLs) are significantly decreased in the CSF and serum of AD patients compared to healthy controls (HCs). These studies were extended to measure R-RAA aPL in serum samples obtained from Alzheimer's Disease Neuroimaging Initiative (ADNI). Serum samples from the ADNI-1 diagnostic groups from participants with mild cognitive impairment (MCI), AD and HCs were blinded for diagnosis and analyzed for R-RAA aPL by ELISA. Demographics, cognitive data at baseline and yearly follow-up were subsequently provided by ADNI after posting assay data. As observed in CSF, R-RAA aPL in sera from the AD diagnostic group were significantly reduced compared to HC. However, the sera from the MCI population contained significantly elevated R-RAA aPL activity relative to AD patient and/or HC sera. The data presented in this study indicate that R-RAA aPL show promise as a blood biomarker for detection of early AD, and warrant replication in a larger sample. Longitudinal testing of an individual for increases in R-RAA aPL over a previously established baseline may serve as a useful early sero-epidemiologic blood biomarker for individuals at risk for developing dementia of the Alzheimer's type
Insulin stimulation of glucose transport in isolated rat adipocytes. Functional evidence for insulin activation of intrinsic transporter activity within the plasma membrane
Personalised versus standard text message prompts for increasing trial participant response to telephone follow-up: an embedded randomised controlled retention trial
Background
Improving retention within randomised controlled trials is important. The effectiveness of different strategies can be assessed using a Study Within A Trial (SWAT). Previous research has shown personalised text message reminders improve clinic attendance rates; however, the results are mixed on improving postal questionnaire return. This SWAT aims to assess whether personalised text message reminders improve completion rates for scheduled telephone follow-ups.
Methods
This SWAT is a two-arm, multi-centre randomised controlled trial with equal allocation. The host trial was the Melatonin for Anxiety prior to General anaesthesia In Children trial (ISRCTN 18296119), where the childâs caregiver was to answer a scheduled telephone follow-up 14 days post-surgery; participants for the SWAT were therefore the caregiver. Text messages were sent 24â48 h before the scheduled call and the personalised version contained the first name of the caregiver which was omitted in the non-personalised version. The primary outcome was questionnaire completion rate, defined as the proportion of caregivers successfully contacted, and completed any of the questionnaires, over the telephone within the follow-up window (day 14 + 7 days).
Results
The SWAT included 100 of the 110 (91%) participants randomised into the host trial. Randomisation within the SWAT was equal between non-personalised (n = 50) and personalised (n = 50) interventions. The overall questionnaire response rate was 73% with a difference between the two interventions of 68% in the non-personalised text message arm and 78% in the personalised text message arm. The adjusted absolute risk difference was 7.1% (95% confidence interval = â10.2%, 24.4%). There was no difference in either the time to response or the number of contact attempts between the two interventions.
Conclusions
There is some evidence that personalised text messages could be effective at increasing response rates when data is collected via telephone and in a population of caregivers for paediatric trial participants. However, similar SWATs have shown mixed results. Given the low-cost and low risks associated with personalising text message reminders, this SWAT could be implemented easily in other RCTs scheduling telephone follow-up appointments.
Trial Registration
ISRCTN 18296119, SWAT 35 (MRC Northern Ireland Network for Trials Methodology Network)
Spectrum of the Y=2 Pentaquarks
By assuming a mass formula for the spectrum of the Y=2 pentaquarks, where the
chromo-magnetic interaction plays a main role, and identifying the lightest
state with the Theta^+(1540), we predict a spectrum in good agreement with the
few I=0 and I=1 candidates proposed in the past.Comment: 12 pages, 4 figures, LaTe
Pentaquark as Kaon-Nucleon Resonance
Several recent experiments have reported evidence for a narrow feature in the
K(+)-neutron system, an apparent resonant state ~ 100 MeV above threshold and
with a width < 25 MeV. This state has been labelled as Theta(+) (previously as
Z(*)), and because of the implied inclusion of a anti-strange quark, is
referred to as a pentaquark, that is, five quarks within a single bag. We
present an alternative explanation for such a structure, as a higher angular
momentum resonance in the isospin zero K(+) -N system. One might call this an
exit channel or a molecular resonance. In a non-relativistic potential model we
find a possible candidate for the kaon-nucleon system with relative angular
momentum L=3, while L=1 and 2 states possess centrifugal barriers too low to
confine the kaon and nucleon in a narrow state at an energy so high above
threshold. A rather strong state-dependence in the potential is essential,
however, for eliminating an observable L=2 resonance at lower energies.Comment: 4 page
Coalescence of nanoscale metal clusters: Molecular-dynamics study
We study the coalescence of nanoscale metal clusters in an inert-gas
atmosphere using constant-energy molecular dynamics. The coalescence proceeds
via atomic diffusion with the release of surface energy raising the
temperature. If the temperature exceeds the melting point of the coalesced
cluster, a molten droplet forms. If the temperature falls between the melting
point of the larger cluster and those of the smaller clusters, a metastable
molten droplet forms and freezes.Comment: 5 figure
Z^* Resonances: Phenomenology and Models
We explore the phenomenology of, and models for, the Z^* resonances, the
lowest of which is now well established, and called the Theta. We provide an
overview of three models which have been proposed to explain its existence
and/or its small width, and point out other relevant predictions, and potential
problems, for each. The relation to what is known about KN scattering,
including possible resonance signals in other channels, is also discussed.Comment: 29 pages, uses RevTeX4; expanded version (published form
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