23 research outputs found
Alkaloids from Gelsemium elegans
Three new alkaloids, gelsebanine (1), 14α-hydroxyelegansamine (2), and 14α-hydroxygelsamydine (3), and a new extraction artifact , gelsebamine (4), together with 12 known alkaloids, were isolated from the stems and leaves of Gelsemium elegans. The structures of 1â4 were determined by spectroscopic methods, especially 2D NMR techniques. Compounds 1â4 were evaluated for cytotoxic activity against four tumor cell lines, and gelsebamine (4) selectively inhibited the A-549 human lung adenocarcinoma cell line