Behaviour Change in Public Health: Evidence and Implications

Article ID 598672The evidence on the role of particular lifestyles, smoking, binge drinking, lack of physical activity, and poor health care seeking, in increased risks for mortality and morbidity is compelling [1]. Understanding the pathways through which these various “unhealthy” behaviours affect health is complicated by the broader ecological context in which they occur. The complexity is further enhanced because behaviours do not occur in isolation and there is often a convergence of associations. Interventions to achieve changes in either single or multiple behaviours have therefore often been limited in their effectiveness and longer term sustainability. In order to develop and implement a meaningful behaviour change agenda we need to establish innovative ways of operationalizing and understanding the complexity of behavioural factors and their dynamic interrelationships and how these collectively affect health. The Behaviour Change Research Cycle (BCRC) (Figure 1) provides a simple illustration of the life cycle of evidence required

Social sciences research in neglected tropical diseases 1: the ongoing neglect in the neglected tropical diseases

Centuries of scientific advances and developments in biomedical sciences have brought us a long way to understanding and managing disease processes, by reducing them to simplified cause-effect models. For most of the infectious diseases known today, we have the methods and technology to identify the causative agent, understand the mechanism by which pathology is induced and develop the treatment (drugs, vaccines, medical or surgical procedures) to cure, manage or control

Prevalence of Postpartum Family Planning Service Coverage in Selected Referral Facilities of Nepal

Introduction: Nepal Society of Obstetricians and Gynecologists jointly with the Nepalese government and with the support from the International Federation of Obstetrics and Gynecology has implemented an initiative to institutionalize postpartum family planning services in selected major referral facilities of Nepal to address the gap of low uptake of postpartum family planning in Nepal. The aim of the study is to find the prevalence of the service coverage of postpartum contraception in the selected facilities. Methods: A descriptive cross-sectional study was conducted in seven major referral facilities across Nepal. Data were collected from the hospital records of all women who delivered in these facilities between October 2018 and March 2019. Ethical approval for this study was obtained from Nepal Health Research Council. Data analysis was done with SPSS version 23. Results: Among the 29,072 deliveries from all the facilities, postpartum family planning counseling coverage was 27,301 (93.9%). The prevalence of uptake of Postpartum Intrauterine Device is 1581 (5.4%) and female sterilization is 1830 (6.3%). In total 11387 mothers (52.2%) had the intention to choose a postpartum family planning method. However, 36% of mothers neither used nor had the intention to choose a postpartum family planning method. Conclusions: The coverage of Postpartum Intrauterine Device counseling service coverage in Nepal is higher in 2018 as compared to 2016-2017 and in other countries implementing Postpartum Intrauterine Device initiatives. However, the prevalence of service coverage of immediate Postpartum Family Planning methods, mainly Postpartum Intrauterine Device in 2018 is lower in Nepal as compared to 2016-2017, and other countries implementing Postpartum Intrauterine Device initiative. More efforts are needed to encourage mothers delivering in the facilities to use the postpartum family planning method

Comparative studies of the spectroscopic properties of nd3+: YAG nanocrystals transparent ceramic and single crystal

Detailed comparative spectroscopic studies of Nd3+ doped YAG nanocrystals, transparent ceramic and single crystal have been performed. Although most of the radiative spectral properties of Nd3+ are almost in good agreement between the three hosts, the non-radiative losses are significantly high in nanocrystals, which are attributed due to the presence of large amount of hydroxyl groups on the nanocrystals surface which deteriorates the quality of the material for laser applications. In addition, wavelength dependent scattering loss for the Nd3+ doped YAG nanocrystals is found significantly high compared to those of Nd3+ doped single crystal and ceramic. © 2012 Optical Society of America

Increased elastase sensitivity and decreased intramolecular interactions in the more transmissible 501Y.V1 and 501Y.V2 SARS-CoV-2 variants' spike protein-an in silico analysis.

Two SARS-CoV-2 variants of concern showing increased transmissibility relative to the Wuhan virus have recently been identified. Although neither variant appears to cause more severe illness nor increased risk of death, the faster spread of the virus is a major threat. Using computational tools, we found that the new SARS-CoV-2 variants may acquire an increased transmissibility by increasing the propensity of its spike protein to expose the receptor binding domain via proteolysis, perhaps by neutrophil elastase and/or via reduced intramolecular interactions that contribute to the stability of the closed conformation of spike protein. This information leads to the identification of potential treatments to avert the imminent threat of these more transmittable SARS-CoV-2 variants

The challenge of forecasting high streamflows 1–3 months in advance with lagged climate indices in southeast Australia

Skilful forecasts of high streamflows a month or more in advance are likely to be of considerable benefit to emergency services and the broader community. This is particularly true for mesoscale catchments (< 2000 km²) with little or no seasonal snowmelt, where real-time warning systems are only able to give short notice of impending floods. In this study, we generate forecasts of high streamflows for the coming 1-month and coming 3-month periods using large-scale ocean–atmosphere climate indices and catchment wetness as predictors. Forecasts are generated with a combination of Bayesian joint probability modelling and Bayesian model averaging. High streamflows are defined as maximum single-day streamflows and maximum 5-day streamflows that occur during each 1-month or 3-month forecast period. Skill is clearly evident in the 1-month forecasts of high streamflows. Surprisingly, in several catchments positive skill is also evident in forecasts of large threshold events (exceedance probabilities of 25%) over the next month. Little skill is evident in forecasts of high streamflows for the 3-month period. We show that including lagged climate indices as predictors adds little skill to the forecasts, and thus catchment wetness is by far the most important predictor. Accordingly, we recommend that forecasts may be improved by using accurate estimates of catchment wetness

Downstream rounding rate of pebbles in the Himalaya

Sediment grains are progressively rounded during their transport down a river. For more than a century, Earth scientists have used the roundness of pebbles within modern sediment, and of clasts within conglomerates, as a key metric to constrain the sediment's transport history and source area(s). However, the current practices of assessment of pebble roundness are mainly qualitative and based on time-consuming manual measurement methods. This qualitative judgement provides the transport history only in a broad sense, such as classifying distance as “near” or “far”. In this study, we propose a new model that quantifies the relationship between roundness and the transport distance. We demonstrate that this model can be applied to the clasts of multiple lithologies including modern sediment, as well as conglomerates, deposited by ancient river systems. We present field data from two Himalayan catchments in Nepal. We use the normalized isoperimetric ratio (IRn), which relates a pebble's area (A) to its perimeter (P), to quantify roundness. The maximum analytical value for IRn is 1, and IRn is expected to increase with transport distance. We propose a non-linear roundness model based on our field data, whereby the difference between a grain's IRn and the maximum value of 1 decays exponentially with transport distance, mirroring Sternberg's model of mass loss or size reduction by abrasion. This roundness model predicts an asymptotic behaviour for IRn, and the distance over which IRn approaches the asymptote is controlled by a rounding coefficient. Our field data suggest that the roundness coefficient for granite pebbles is 9 times that of quartzite pebbles. Using this model, we reconstruct the transport history of a Pliocene paleo-river deposit preserved at the base of the Kathmandu intermontane basin. These results, along with other sedimentary evidence, imply that the paleo-river was much longer than the length of the Kathmandu Basin and that it must have lost its headwaters through drainage capture. We further explore the extreme rounding of clasts from Miocene conglomerate of the Siwalik zone and find evidence of sediment recycling.</p

Infrared and upconversion spectroscopic studies of high Er3+content transparent YAG ceramic

In this article, we report the detailed spectroscopic studies of high Er3+content (50%) transparent YAG ceramic co-doped with nominal Cr3+ content (0.1 mol %). Various radiative and non-radiative spectroscopic properties such as radiative decay time, fluorescence branching ratio, emission/absorption cross sections, internal radiative quantum yields of the infrared and the upconverted emission bands are explored using standard experimental and theoretical methods and compared with YAG single crystal. Results show that although the non-radiative losses are high for 50% Er doped ceramic; several radiative spectral properties are almost in agreement with those for the single crystal YAG. Furthermore, because of the low dopant concentration of Cr3+, the sensitizing effect of Cr3+ was not observed. © 2011 Optical Society of America

Prevalence of cardiovascular risk factors among chronic kidney disease patients undergoing hemodialysis in a tertiary care center, Kathmandu, Nepal

The risk of cardiovascular disease is higher in chronic kidney disease patients compared to the general population and its impact is higher in developing countries compared to the developed countries. With this background in mind, we aimed to evaluate the prevalence of different cardiovascular risk factors in patients on maintenance hemodialysis in a tertiary care center. Chronic kidney disease patients aged 18 years and above who were under maintenance hemodialysis in the hemodialysis unit of Nepal Medical College were included in the study. Pre-dialysis venous blood samples from the participants were collected and analyzed for serum calcium, phosphorus, total protein, albumin and hemoglobin. Calcium phosphate product was calculated. Out of 100 study participants, 52% were male and 48% were female. Age-wise distribution showed 38% of the participants were below 40 years. The mean age of the participants was 45.86 ± 14.4 years. Ninety-three percent had hypertension and 29% had diabetes mellitus. Hypocalcemia was present in 80%, hyperphosphatemia was seen among 81% and high calcium phosphate product was present in 33% of the participants. Low hemoglobin (&lt; 10gm/dL) was found in 86%. The cardiovascular risk trend in the Nepalese chronic kidney disease population is fairly different compared to the western population. Participants were younger. Prevalence of hypertension and diabetes was high. The high prevalence of anemia might be due to unaffordability of the participants for regular erythropoietin therapy. Inadequately managed hyperphosphatemia despite the widespread use of phosphorus binders, is still a major clinical challenge in patients on hemodialysis