In vitro susceptibility of gram-positive cocci to paldimycin

Paldimycin (U-70138F) is a new antimicrobial agent with activity against gram-positive cocci. Clinical isolates of staphylococci and streptococci were tested. MICs were higher in Mueller-Hinton broth than in nutrient broth. Change in pH had minimal effect on the MICs in either broth. When inoculum size was varied, an inoculum effect was observed. The gram-positive cocci tested were generally more susceptible to paldimycin than to vancomycin.</jats:p

Susceptibility of clinical isolates of bacteria to cefamandole, cefoxitin and cephalothin

The in vitro susceptibility was determined of 274 isolates to cephalothin and two new antibiotics, cefamandole and cefoxitin. Cefamandole was comparable to cephalothin in preventing growth of cultures of the gram positive organisms except for penicillin-resistant Staphylococcus aureus which was more sensitive to cephalothin. Cefamandole was more active than cephalothin against all the gram negative bacteria including Haemophilus influenzae and in addition it was active against many strains of Enterobacter sp. Cefoxitin was less active than cephalothin against the gram positive organisms but it was more active against most of the gram negative bacteria. In addition. It was active against Serratia and indole positive Proteus which are uniformly resistant to cephalothin

Comparison of enzyme-multiplied immunoassay technique with fluorescence polarization immunoassay for determination of gentamicin and tobramycin levels in serum

We assayed serum gentamicin and tobramycin specimens by the enzyme multiplied immunoassay technique (Syva EMIT) and the fluorescence polarization immunoassay (Abbott TDx). When interassay and intraassay control samples were evaluated, both methods gave an overall coefficient of variation of less than +/- 10%. Using patient serum samples, we obtained excellent correlation with both methods in the assay of gentamicin (correlation coefficient, 0.985) and tobramycin (correlation coefficient, 0.982).</jats:p

Water-table elevations on the Hanford Site, 1990

The Pacific Northwest Laboratory prepared water-table maps of the US Department of Energy&#x27;s Hanford Site for June 1990 from water-level elevations measured in 224 wells across the Hanford Site. The greatest changes in the elevation of the water table at Hanford occurred beneath the decommissioned U Pond, 200-East Area, the 100-N Area, the 1100 and 3000 Areas, and near the Columbia River. The elevation of the ground-water mound beneath the decommissioned U Pond continued to decline, decreasing as much as 0.8 m (2.6 ft) between December 1989 and December 1990. This decline has been observed in wells in much of the adjacent 200-West Area and is primarily the result of continued dissipation of the ground-water mound beneath U Pond since it was deactivated in 1984. 21 refs., 12 figs

Water-table elevations on the Hanford Site and outlying areas, 1991

The Pacific Northwest Laboratory prepared water-table maps of the US Department of Energy`s Hanford Site for June-August 1991 from water-level elevations measures in 359 wells across the Hanford Site and outlying areas. The greatest changes in the elevation of the water table at Hanford occurred beneath the decommissioned U Pond, the 200-East Area, B Pond, the 100-N Area, the 1100 and 3000 Areas, the Cold Creek valley, and adjacent to the Columbia River

Water-table elevations on the Hanford Site and outlying areas, 1991

The Pacific Northwest Laboratory prepared water-table maps of the US Department of Energy's Hanford Site for June-August 1991 from water-level elevations measures in 359 wells across the Hanford Site and outlying areas. The greatest changes in the elevation of the water table at Hanford occurred beneath the decommissioned U Pond, the 200-East Area, B Pond, the 100-N Area, the 1100 and 3000 Areas, the Cold Creek valley, and adjacent to the Columbia River