150 research outputs found
Parodon orinocensis (Bonilla et al., 1999) (Characiformes: Parodontidae): emendations and generic reallocation
Sanguinicola platyrhynchi n. sp. (Digenea: Sanguinicolidae) parasite of visceral cavity of Hemisorubim platyrhynchos (Valenciennes, 1840) (Pisces: Pimelodidae) from the floodplain of the upper Paraná River, Brazil
Rotação radiométrica para detecção de mudanças na paisagem de tensão ecológica em Roraima.
First record of Tuxophorus caligodes (Siphonostomatoida, Tuxophoridae) in sea-farmed cobia, Rachycentron canadum, in Brazil
Occurrence of gastrointestinal and renal helminths inZenaida auriculata (Des Murs, 1847) trap-captured from Brazil
Five-year survival after first-ever ischaemic stroke is worse in total anterior circulation infarcts: the SINPAC cohort.
Parasitic communities of Hoplosternum littorale (Hancock, 1828) as indicators of environmental impact
Redescription of Corydoras guapore Knaack, 1961 (Siluriformes: Callichthyidae), a midwater Corydoradinae species from the rio Guaporé basin
Genetic variability in three species of Gymnotus Linnaeus, 1758 (Gymnotiformes: Gymnotidae) from Caracu stream of the upper Paraná River basin, Brazil
Prolonged Survival of Allografts Induced by Mycobacterial Hsp70 Is Dependent on CD4+CD25+ Regulatory T Cells
Background: Heat shock proteins (Hsps) are stress induced proteins with immunomodulatory properties. The Hsp70 of Mycobacterium tuberculosis (TBHsp70) has been shown to have an anti-inflammatory role on rodent autoimmune arthritis models, and the protective effects were demonstrated to be dependent on interleukin-10 (IL-10). We have previously observed that TBHsp70 inhibited maturation of dendritic cells (DCs) and induced IL-10 production by these cells, as well as in synovial fluid cells. Methodology/Principal Findings: We investigated if TBHsp70 could inhibit allograft rejection in two murine allograft systems, a transplanted allogeneic melanoma and a regular skin allograft. In both systems, treatment with TBHsp70 significantly inhibited rejection of the graft, and correlated with regulatory T cells (Tregs) recruitment. This effect was not tumor mediated because injection of TBHsp70 in tumor-free mice induced an increase of Tregs in the draining lymph nodes as well as inhibition of proliferation of lymph node T cells and an increase in IL-10 production. Finally, TBHsp70 inhibited skin allograft acute rejection, and depletion of Tregs using a monoclonal antibody completely abolished this effect. Conclusions/Significance: We present the first evidence for an immunosuppressive role for this protein in a graft rejection system, using an innovative approach - immersion of the graft tissue in TBHsp70 solution instead of protein injection. Also, this is the first study that demonstrates dependence on Treg cells for the immunosuppressive role of TBHsp70. This finding is relevant for the elucidation of the immunomodulatory mechanism of TBHsp70. We propose that this protein can be used not only for chronic inflammatory diseases, but is also useful for organ transplantation management.Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS)Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Financiadora de Estudos e Projetos (FINEP
- …