CIP2A Immunosensor Comprised of Vertically-aligned Carbon Nanotube Interdigitated Electrodes Towards Point-of-Care Oral Cancer Screening

Vertically aligned carbon nanotube array (VANTA) coatings have recently garnered much attention due in part to their unique material properties including light absorption, chemical inertness, and electrical conductivity. Herein we report the first use of VANTAs grown via chemical vapor deposition in a 2D interdigitated electrode (IDE) footprint with a high height-to-width aspect ratio (3:1 or 75:25 µm). The VANTA-IDE is functionalized with an antibody (Ab) specific to the human cancerous inhibitor PP2A (CIP2A)—a alivary oncoprotein that is associated with a variety of malignancies such as oral, breast, and multiple myeloma cancers. The resultant immunosensor is capable of detecting CIP2A label-free across a wide linear sensing range (1 – 100 pg/mL) with a detection limit of 0.24 pg/mL within saliva supernatant—a range that is more sensitive than the corresponding CIP2A enzyme linked immunosorbent assay (ELISA). These results help pave the way for rapid cancer screening tests at the point-of-care (POC) such as for the early-stage diagnosis of oral cancer at a dentist\u27s office

Genome-wide association study identifies PERLD1 as asthma candidate gene

10.1186/1471-2350-12-170BMC Medical Genetics12-BMGM

Why women refuse Postpartum IUCD?

Background: Women are highly motivated and receptive to accepting family planning methods during the antenatal period. Hence, we conducted this study to evaluate the refusal rate and reasons for the refusal of postpartum Intrauterine Contraceptive Devices (PPIUCD). Material and Methods: The present cross-sectional study was conducted in the Department of Obstetrics and Gynaecology, at a tertiary Care Centre, on 400 antenatal women from November 2023 for 2 months. Results: In present study, 331 (82.8%) subjects were knowing condom as contraceptive, followed by 310 (77.5%) subjects knowing about copper T. 282 (70.5%) subjects were knowing tubectomy, 264 (68.5%) were knowing oral contraceptives, 264 (66%) were knowing vasectomy, 205 (51.2%) were knowing natural methods, 179 (44.8%) were knowing injectable contraceptive, 83 (20.8%) were knowing Saheli, and 27 (6.8%) subjects were not knowing any contraceptive method. In total, 185 (46.5%) subjects knew that Copper T could be inserted immediately after delivery followed by 83 (20.9%) who knew that copper T could be inserted after menses. Sixty-nine (17.3%) knew that copper T could be inserted during a cesarean section. A total of 352 (88%) subjects refused postpartum copper T as a method of contraception. Only 48 (12%) subjects were willing to insert postpartum copper T. After counseling, the rate of acceptance of copper T insertion increased from 48 (12%) to 102 (25.5%). Conclusion: Knowledge of PPIUCD in the present study was good, but the refusal rate was high. The commonest reason was fear of side effects

Design and Fabrication of PET Filament Making Machine

Abstract: 3D printing is a form of additive manufacturing technology where a 3D object is created by laying down successive layers of material. It is mechanized method whereby 3D objects are quickly made on a reasonably sized machine connected to a computer containing blueprints for the object. As 3D printing is growing fast and giving a boost to product development, the factories doing 3D printing need to continuously meet the printing requirements and maintain an adequate amount of inventory of the filament. As the manufactures have to buy these filaments from various vendors, the cost of 3D printing increases. To overcome the problem faced by the manufacturers, small workshop owners, the need of 3D filament making machine arises. This project focuses on designing and fabricating a portable fused deposition 3D printer filament making machine with cheap and easily available components to draw 2 mm diameter ABS filament. Keywords: 3D printing, filament, recycling, PET bottles, machine</jats:p

Microseismicity and acoustic emission for landslide monitoring (North-East Italy)

In the North-East Italy, along the left side of the Tagliamento River, the area around an old road tunnel, named Passo della Morte, is involved in a Deep Seated Gravitational Slope Deformation. The most active blocks move up to 5 cm/year. The western part is moreover characterized by sub-vertical limestone layers and a dense system of discontinuities and fractures which create ideal conditions for rapid rock slope failure. High risk is represented by the interference with a national road and the Tagliamento River. A microseismicity and acoustic emission monitoring system was designed to monitor signals generated by rock slope deformation, in order to obtain informations about the rock slide mechanism, to recognize precursory phenomena or to provide precursory patterns. It is composed by a seismometer and a piezoelectric transducer. The amount of microseisms and acoustic emission detected by these instruments was analyzed and a close relation between them was found. The influence of precipitations in the rock mass deformation was evaluated and an evident correlation between precipitation and microseisms/acoustic emission was found