6 research outputs found
Few layer graphene does not affect the function and the autophagic activity of primary lymphocytes
Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses
Selective cell death of latently HIV-infected CD4+ T cells mediated by autosis inducing nanopeptides
Autophagy in the renewal, differentiation and homeostasis of immune cells
Across all branches of the immune system, the process of autophagy is fundamentally important in cellular development, function and homeostasis. Strikingly, this evolutionarily ancient pathway for intracellular recycling has been adapted to enable a high degree of functional complexity and specialization. However, although the requirement for autophagy in normal immune cell function is clear, the mechanisms involved are much less so and encompass control of metabolism, selective degradation of substrates and organelles and participation in cell survival decisions. We review here the crucial functions of autophagy in controlling the differentiation and homeostasis of multiple immune cell types and discuss the potential mechanisms involved