Characterization of New Titanium Oxide Polymer Hybrid Membranes for Biofilm Formation

International audiencePresently, there is great need to create new matrices for diverse applications particularly in the fields of biotechnology and food industry. Here, we report on the synthesis of new matrices based on a mixture of polymer cellulose acetate butyrate/copolymer polyacrylonitrile acrylamide/TiO2. The characterization of the new matrices was performed using IR spectroscopy, QCM technology, and SEM. The tests revealed that when we use our polymers as carriers, there is a limit for the concentration of titanium of 5%. Further increasing of Ti concentration leads to precipitation processes. The QCM analyses show that a low concentration of Ti(OBu)4 does not influence the viscosity of the matrices obtained, but their elasticity changes significantly. The membranes obtained were successfully applied for biofilm formation of Yeast strain Saccharomyces cerevisiae

Synthesis of new hybrid cell penetrating peptides-medical drugs molecules

In 1988 the remarkable ability of a peptide to traverse a cell's plasma membrane independent of a membrane receptor was revealed. They cause changes in the membranes leading to their permeability. This type of peptide molecules is called cell penetrating peptides (CPP). One of these peptides is sweet arrow peptide (SAP). Herein, we report for the synthesis of four analogues of SAP. A new interesting strategy for synthesis of Asn and Gln containing peptides starting from Glu and Asp and using Rink amide resin was applied