Using adult mosquitoes to transfer insecticides to Aedes aegypti larval habitats.

Vector control is a key means of combating mosquito-borne diseases and the only tool available for tackling the transmission of dengue, a disease for which no vaccine, prophylaxis, or therapeutant currently exists. The most effective mosquito control methods include a variety of insecticidal tools that target adults or juveniles. Their successful implementation depends on impacting the largest proportion of the vector population possible. We demonstrate a control strategy that dramatically improves the efficiency with which high coverage of aquatic mosquito habitats can be achieved. The method exploits adult mosquitoes as vehicles of insecticide transfer by harnessing their fundamental behaviors to disseminate a juvenile hormone analogue (JHA) between resting and oviposition sites. A series of field trials undertaken in an Amazon city (Iquitos, Peru) showed that the placement of JHA dissemination stations in just 3-5% of the available resting area resulted in almost complete coverage of sentinel aquatic habitats. More than control mortality occurred in 95-100% of the larval cohorts of Aedes aegypti developing at those sites. Overall reductions in adult emergence of 42-98% were achieved during the trials. A deterministic simulation model predicts amplifications in coverage consistent with our observations and highlights the importance of the residual activity of the insecticide for this technique

Eliminating Malaria Vectors.

Malaria vectors which predominantly feed indoors upon humans have been locally eliminated from several settings with insecticide treated nets (ITNs), indoor residual spraying or larval source management. Recent dramatic declines of An. gambiae in east Africa with imperfect ITN coverage suggest mosquito populations can rapidly collapse when forced below realistically achievable, non-zero thresholds of density and supporting resource availability. Here we explain why insecticide-based mosquito elimination strategies are feasible, desirable and can be extended to a wider variety of species by expanding the vector control arsenal to cover a broader spectrum of the resources they need to survive. The greatest advantage of eliminating mosquitoes, rather than merely controlling them, is that this precludes local selection for behavioural or physiological resistance traits. The greatest challenges are therefore to achieve high biological coverage of targeted resources rapidly enough to prevent local emergence of resistance and to then continually exclude, monitor for and respond to re-invasion from external populations

TIMED Doppler Interferometer on the Thermosphere Ionosphere Mesosphere Energetics and Dynamics satellite: Data product overview

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/94699/1/jgra18252.pd

Estimating regional evapotranspiration from remotely sensed data by surface energy balance models

Spatial and temporal variations of surface radiative temperatures of the burned and unburned areas of the Konza tallgrass prairie were studied. The role of management practices, topographic conditions and the uncertainties associated with in situ or airborne surface temperature measurements were assessed. Evaluation of diurnal and seasonal spectral characteristics of the burned and unburned areas of the prairie was also made. This was accomplished based on the analysis of measured spectral reflectance of the grass canopies under field conditions, and modelling their spectral behavior using a one dimensional radiative transfer model

Target product profiles for protecting against outdoor malaria transmission.

BACKGROUND\ud \ud Long-lasting insecticidal nets (LLINs) and indoor residual sprays (IRS) have decimated malaria transmission by killing indoor-feeding mosquitoes. However, complete elimination of malaria transmission with these proven methods is confounded by vectors that evade pesticide contact by feeding outdoors.\ud \ud METHODS\ud \ud For any assumed level of indoor coverage and personal protective efficacy with insecticidal products, process-explicit malaria transmission models suggest that insecticides that repel mosquitoes will achieve less impact upon transmission than those that kill them outright. Here such models are extended to explore how outdoor use of products containing either contact toxins or spatial repellents might augment or attenuate impact of high indoor coverage of LLINs relying primarily upon contact toxicity.\ud \ud RESULTS\ud \ud LLIN impact could be dramatically enhanced by high coverage with spatial repellents conferring near-complete personal protection, but only if combined indoor use of both measures can be avoided where vectors persist that prefer feeding indoors upon humans. While very high levels of coverage and efficacy will be required for spatial repellents to substantially augment the impact of LLINs or IRS, these ambitious targets may well be at least as practically achievable as the lower requirements for equivalent impact using contact insecticides.\ud \ud CONCLUSIONS\ud \ud Vapour-phase repellents may be more acceptable, practical and effective than contact insecticides for preventing outdoor malaria transmission because they need not be applied to skin or clothing and may protect multiple occupants of spaces outside of treatable structures such as nets or houses

Habitat characterization and spatial distribution of Anopheles sp. mosquito larvae in Dar es Salaam (Tanzania) during an extended dry period

Introduction: By 2030, more than 50% of the African population will live in urban areas. Controlling malaria reduces the disease burden and further improves economic development. As a complement to treated nets and prompt access to treatment, measures targeted against the larval stage of Anopheles sp. mosquitoes are a promising strategy for urban areas. However, a precise knowledge of the geographic location and potentially of ecological characteristics of breeding sites is of major importance for such interventions. Methods: In total 151 km2 of central Dar es Salaam, the biggest city of Tanzania, were systematically searched for open mosquito breeding sites. Ecologic parameters, mosquito larvae density and geographic location were recorded for each site. Logistic regression analysis was used to determine the key ecological factors explaining the different densities of mosquito larvae. Results: A total of 405 potential open breeding sites were examined. Large drains, swamps and puddles were associated with no or low Anopheles sp. larvae density. The probability of Anopheles sp. larvae to be present was reduced when water was identified as turbid . Small breeding sites were more commonly colonized by Anopheles sp. larvae. Further, Anopheles gambiae s.l. larvae were found in highly organically polluted habitats. Conclusions: Clear ecological characteristics of the breeding requirements of Anopheles sp. larvae could not be identified in this setting. Hence, every stagnant open water body, including very polluted ones, have to be considered as potential malaria vector breeding sites. © 2005 Sattler et al; licensee BioMed Central Ltd

Centaurus A: multiple outbursts or bursting bubble?

We present new radio observations of the brighter region of the northern lobe (the Northern Middle Lobe, NML) of Centaurus A obtained at 20 cm with the Australia Telescope Compact Array. The angular resolutions are ~50 and ~130 arcsec, therefore much higher than for the previously available radio images of this region. The most interesting feature detected is a large-scale jet that connects the inner radio lobe and the NML and that is imaged for the first time. The NML itself appears as diffuse emission with a relatively bright ridge on the eastern side. The radio morphology of Centaurus A and, in particular, its NML could be the result of a precessing jet that has undergone a strong interaction with the environment at least in the northern side. The very big drop in intensity between the inner jet and the large-scale jet can be explained with a sequence of bursts of activity at different epochs in the life of the source. Alternatively (or additionally) a ``bursting bubble'' model is proposed which could also explain the good collimation of the large-scale jet. In this model, the plasma accumulated in the inner lobe would be able to ``burst'' out only through one nozzle that would be the region where the large-scale jet forms. From the comparison between the radio emission and the regions of ionized gas we find that the inner optical filament falls about 2 arcmin (~2 kpc) away from the large-scale radio jet. Thus, this filament does not seem to have experienced a direct interaction with the radio plasma. The outer filaments appear to be, in projection, closer to the radio emission, arguing for a direct interaction with the radio jet. However, also in this case a more complicated interaction than assumed so far has to be occuring.Comment: To appear in MNRAS; 11 pages, LateX, 7 figures. Fig 1 is available at http://www.ira.bo.cnr.it/~rmorgant/Centaurus

Space‐time analysis of TIMED Doppler Interferometer (TIDI) measurements

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/95273/1/grl12774.pd

Supporting National User Communities at NERSC and NCAR

The National Energy Research Scientific Computing Center(NERSC) and the National Center for Atmospheric Research (NCAR) are twocomputing centers that have traditionally supported large national usercommunities. Both centers have developed responsive approaches to supportthese user communities and their changing needs, providing end-to-endcomputing solutions. In this report we provide a short overview of thestrategies used at our centers in supporting our scientific users, withan emphasis on some examples of effective programs and futureneeds