Economic and Political Factors Affecting the Rapprochement of Iran and the EAEU

Aim. Identify economic and political factors that are beneficial to Iran — EAEU relations.Tasks. Identify the prerequisites of the economic and political point of view, both in history and at the present stage, which would explain the prospects for rapprochement between Iran and the Eurasian Economic Union.Methods. The methods of scientific research in the work should include analysis (to understand the impact of historical events in Iran), as well as the deductive method and synthesis, which will allow to identify a set of factors affecting the improvement of relations between Iran and the EAEU.Results. The “White Revolution” promoted by the West in Iran was not viable and eventually pushed Iran to cho ose a more original way and ways of international cooperation, taking into account national specificity or following the policy of non-interference, which becomes the integration within the EAEU. Another favorable political aspect for Iran is cooperation with Russia , which strengthens confidence that the coun try will not be influenced by political activities and is based on mutual respect and equality. The current economic agreements demonstrate mutual willingness to develop the existing economic relations, as well as have a positive impact on foreign trade and allow taking into account each other’s mutual interests in economic terms, and contribute to the resolution of certain problems.Conclusion. In view of the considered political and economic factors, the rapprochement between Iran and the EAEU can indeed be considered a promising and relevant political trend, despite the existing obstacles. Both sides are positive about strengthening their relations, so it is important to continue working to remove the existing obstacles to the development of cooperation

Scaling of THz-conductivity at metal-insulator transition in doped manganites

Magnetic field and temperature dependence of the Terahertz conductivity and permittivity of the colossal magnetoresistance manganite Pr_{0.65}Ca_{0.28}Sr_{0.07}MnO_3 (PCSMO) is investigated approaching the metal-to-insulator transition (MIT) from the insulating side. In the charge-ordered state of PCSMO both conductivity and dielectric permittivity increase as function of magnetic field and temperature. Universal scaling relationships between the changes in permittivity and conductivity are observed in a broad range of temperatures and magnetic fields. Similar scaling is also seen in La_{1-x}Sr_xMnO_3 for different doping levels. The observed proportionality points towards the importance of pure ac-conductivity and phononic energy scale at MIT in manganites.Comment: 5 pages, 4 figure

High-field AFMR in single-crystalline La_{0.95}Sr_{0.05}MnO_3: Experimental evidence for the existence of a canted magnetic structure

High-field antiferromagnetic-resonance (AFMR) spectra were obtained in the frequency range 60 GHz < \nu < 700 GHz and for magnetic fields up to 8 T in twin-free single crystals of La_{0.95}Sr_{0.05}MnO_3. At low temperatures two antiferromagnetic modes were detected, which reveal different excitation conditions and magnetic field dependencies. No splitting of these modes was observed for any orientation of the static magnetic field excluding the phase-separation scenario for this composition. Instead, the full data set including the anisotropic magnetization can be well described using a two-sublattice model of a canted antiferromagnetic structure.Comment: 4 pages, 3 figure

Predictors of atrial fibrillation in patients with COVID-19

Early diagnosis of atrial fibrillation (AF) predictors in coronavirus disease 2019 (COVID-19) and the appointment of additional therapy to prevent arrhythmias will improve the prognosis of patients.Aim. To identify predictors of AF in patients with COVID-19.Material and methods. This retrospective study included 1473 patients hospitalized with COVID-19. Depending on AF occurrence, the patients were divided into 2 groups as follows: group I included 95 patients with AF episodes during hospitalization; group II consisted of 1378 patients who did not have AF during hospitalization. All patients underwent a complete blood count and urine tests, a biochemical and coagulation blood tests, 12-lead electrocardiography, chest computed tomography (CT), and echocardiography.Results. Chest CT found that lung tissue involvement in patients of group I was significantly greater than in group II (p&lt;0,05). The number of patients with significant lung involvement &gt;50% (CT-3 and CT-4) was significantly higher in the AF group than in the control group. The average room air oxygen saturation upon admission to the hospital were significantly lower in patients with AF than in the comparison group (p&lt;0,05). Multivariate analysis showed that following factors have a significant effect on AF development in COVID-19 patients: age &gt;60 years, hypertension, coronary artery disease, heart failure, increased left atrial volume, large lung tissue involvement, and increased interleukin- 6 level.Conclusion. There are two following groups of predictors initiating AF in COVID-19: generally known (older age, cardiovascular disease, increased left atrial volume) and those that determine the severe COVID-19 course (large lung damage and high interleukin-6 levels)

Iron deficiency anemia in pregnant women

Introduction The problem of iron deficiency anemia (IDA), especially in pregnant women, continues to be relevant. Despite the achieved methods of diagnosis and treatment, the number of pregnant women with IDA continues to grow. Thus, according to WHO 2020 data, the prevalence of anemia among women of reproductive age ranged from 9.1 % in Australia to 69.6 % in Yemen. The aim of the work was to determination of the current state of the problem of IDA in pregnant women. Materials and methods Original articles, randomized clinical trials, and meta-analyses were reviewed in the Scopus database, PubMed and the eLibrary platform, using the key words “iron”, “oral”, “intravenous iron”, “intravenous iron therapy”, “pregnancy”, “anemia”, “treatment”, “randomized control trial”, “anemia in pregnancy”, “treatment of anemia in pregnancy”, “intravenous iron in pregnancy”, “IDA complications for mother and fetus”. The depth of the search was 5 years. Results and discussion There are different views on the classification and diagnosis of IDA in the guidelines of professional organizations. According to most guidelines hemoglobin and ferritin levels are the most reliable tests for the verification and prediction of IDA. Despite the fact that the peculiarities of the pathogenesis and approaches to the treatment of IDA have been studied, its prevalence among women remains very high. The reasons for this lie in inadequate diagnosis and incomplete therapy in terms of its duration and drugs selection. The methods of diagnosis and treatment of IDA are currently being actively studied and improved in anticipation of obtaining the greatest benefits. Conclusion Complications of IDA in the third trimester for newborns are the development of anemia, impaired development of the nervous system and cognitive disorders, which requires active prevention in the second trimester using, among other things, parenteral iron preparations.Введение. Проблема железодефицитной анемии (ЖДА), особенно у беременных, продолжает оставаться актуальной. Несмотря на достижения в разработке методов диагностики и лечения, число беременных с ЖДА продолжает расти. Так, по данным ВОЗ за 2020 г. распространенность анемии среди женщин репродуктивного возраста варьировала от 9,1 % в Австралии до 69,6 % в Йемене. Цель работы − определение современного состояния проблемы ЖДА у беременных на основе анализа литературы. Материалы и методы. Отобраны оригинальные статьи, рандомизированные клинические исследования и мета-анализы. Подбор источников осуществлен в базах данных Scopus, PubMed по поисковым словам: iron, oral, intravenous iron, intravenous iron therapy, pregnancy, anemia, treatment, randomized control trial, anemia in pregnancy, treatment of anemia in pregnancy, intravenous iron in pregnancy; и на платформе eLibrary по поисковым словам: железо, пероральный прием, внутривенное железо, внутривенная терапия железом, беременность, анемия, лечение, рандомизированное контрольное исследование, анемия во время беременности, лечение анемии во время беременности, внутривенное введение железа во время беременности, осложнения ЖДА для матери и плода. Глубина поиска – 5 лет. Результаты и обсуждение. Имеются разные точки зрения на классификацию и диагностику ЖДА в руководствах профессиональных организаций. По мнению большинства руководств наиболее достоверными для верификации и предикции ЖДА являются определение уровня гемоглобина и ферритина. Несмотря на то, что в настоящее время изучены особенности патогенеза и подходы к лечению ЖДА, ее распространенность среди женщин остается очень высокой. Причины этого кроются в недостаточной диагностике и неполноценной терапии с точки зрения ее продолжительности и выбора препарата. Методы диагностики и лечения ЖДА в настоящее время активно изучаются и совершенствуются в ожидании получения наибольших преимуществ. Заключение. Осложнениями ЖДА в третьем триместре для новорожденных являются развитие анемии, нарушение развития нервной системы и когнитивные расстройства, что требует активной профилактики во втором триместре с использованием, в том числе, и парентеральных препаратов железа

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Impairments in neuronal intracellular calcium (iCa2+) handling may contribute to Alzheimer’s disease (AD) development. Metabolic dysfunction and progressive neuronal loss are associated with AD progression, and mitochondrial calcium (mCa2+) signaling is a key regulator of both of these processes. Here, we report remodeling of the mCa2+ exchange machinery in the prefrontal cortex of individuals with AD. In the 3xTg-AD mouse model impaired mCa2+ efflux capacity precedes neuropathology. Neuronal deletion of the mitochondrial Na+/Ca2+ exchanger (NCLX, Slc8b1 gene) accelerated memory decline and increased amyloidosis and tau pathology. Further, genetic rescue of neuronal NCLX in 3xTg-AD mice is sufficient to impede AD-associated pathology and memory loss. We show that mCa2+ overload contributes to AD progression by promoting superoxide generation, metabolic dysfunction and neuronal cell death. These results provide a link between the calcium dysregulation and metabolic dysfunction hypotheses of AD and suggest mCa2+ exchange as potential therapeutic target in AD