71 research outputs found
The Lantern Vol. 4, No. 2, March 1936
• Cooperative Democracy • Fantasy • Drama: Porgy and Bess • Foreign Entanglements • The Kibitzer • My Gallery of Old Folks • My Friend, Mark Twain • Jimmy and Waffles • Reminiscence • Gold Dust • After Twenty Centuries • All the World\u27s a Stage • Early Medicinehttps://digitalcommons.ursinus.edu/lantern/1007/thumbnail.jp
Nuclear astrophysics: the unfinished quest for the origin of the elements
Half a century has passed since the foundation of nuclear astrophysics. Since
then, this discipline has reached its maturity. Today, nuclear astrophysics
constitutes a multidisciplinary crucible of knowledge that combines the
achievements in theoretical astrophysics, observational astronomy,
cosmochemistry and nuclear physics. New tools and developments have
revolutionized our understanding of the origin of the elements: supercomputers
have provided astrophysicists with the required computational capabilities to
study the evolution of stars in a multidimensional framework; the emergence of
high-energy astrophysics with space-borne observatories has opened new windows
to observe the Universe, from a novel panchromatic perspective; cosmochemists
have isolated tiny pieces of stardust embedded in primitive meteorites, giving
clues on the processes operating in stars as well as on the way matter
condenses to form solids; and nuclear physicists have measured reactions near
stellar energies, through the combined efforts using stable and radioactive ion
beam facilities. This review provides comprehensive insight into the nuclear
history of the Universe and related topics: starting from the Big Bang, when
the ashes from the primordial explosion were transformed to hydrogen, helium,
and few trace elements, to the rich variety of nucleosynthesis mechanisms and
sites in the Universe. Particular attention is paid to the hydrostatic
processes governing the evolution of low-mass stars, red giants and asymptotic
giant-branch stars, as well as to the explosive nucleosynthesis occurring in
core-collapse and thermonuclear supernovae, gamma-ray bursts, classical novae,
X-ray bursts, superbursts, and stellar mergers.Comment: Invited Review. Accepted for publication in "Reports on Progress in
Physics" (version with low-resolution figures
Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract
Cataract is one of the earliest secondary complications of diabetes mellitus. The lens is a closed system with limited capability to repair or regenerate itself. Current evidence supports the view that cataractogenesis is a multifactorial process. Mechanisms related to glucose toxicity, namely oxidative stress, processes of non-enzymatic glycation and enhanced polyol pathway significantly contribute to the development of eye lens opacity under conditions of diabetes. There is an urgent need for inexpensive, non-surgical approaches to the treatment of cataract. Recently, considerable attention has been devoted to the search for phytochemical therapeutics. Several pharmacological actions of natural flavonoids may operate in the prevention of cataract since flavonoids are capable of affecting multiple mechanisms or etiological factors responsible for the development of diabetic cataract. In the present paper, natural flavonoids are reviewed as potential agents that could reduce the risk of cataract formation via affecting multiple pathways pertinent to eye lens opacification. In addition, the bioavailability of flavonoids for the lens is considered
L'Italia come modello per l'Europa e per il mondo nelle politiche sanitarie per il trattamento dell'epatite cronica da HCV
The World Health Organization foresees the
elimination of HCV infection by 2030. In light of this and the curre
nt, nearly worldwide, restriction in direct-acting agents
(DAA) accessibility due to their high price, we aimed to evaluate
the cost-effectiveness of two alternative DAA treatment
policies: Policy 1 (universal): treat all patients, regardless of the fibrosis stage; Policy 2 (prioritized): treat only priori
tized
patients and delay treatment of the
remaining patients until reaching stage F3. T
he model was based on patient’s data
from the PITER cohort. We demonstrated that extending HC
V treatment of patients in any fibrosis stage improves health
outcomes and is cost-effective
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