The cat's cradle network

In this paper we will argue that the representation of context in knowledge management is appropriately served by the representation of the knowledge networks in an historicised form. Characterising context as essentially extra to any particular knowledge representation, we argue that another dimension to these be modelled, rather than simply elaborating a form in its own terms. We present the formalism of the cat's cradle network, and show how it can be represented by an extension of the Pathfinder associative network that includes this temporal dimension, and allows evolutions of understandings to be traced. Grounding its semantics in communities of practice ensures utility and cohesiveness, which is lost when mere externalities of a representation are communicated in fully fledged forms. The scheme is general and subsumes other formalisms for knowledge representation. The cat's cradle network enables us to model such community-based social constructs as pattern languages, shared memory and patterns of trust and reliance, by placing their establishment in a structure that shows their essential temporality

Just below the surface: developing knowledge management systems using the paradigm of the noetic prism

In this paper we examine how the principles embodied in the paradigm of the noetic prism can illuminate the construction of knowledge management systems. We draw on the formalism of the prism to examine three successful tools: frames, spreadsheets and databases, and show how their power and also their shortcomings arise from their domain representation, and how any organisational system based on integration of these tools and conversion between them is inevitably lossy. We suggest how a late-binding, hybrid knowledge based management system (KBMS) could be designed that draws on the lessons learnt from these tools, by maintaining noetica at an atomic level and storing the combinatory processes necessary to create higher level structure as the need arises. We outline the “just-below-the-surface” systems design, and describe its implementation in an enterprise-wide knowledge-based system that has all of the conventional office automation features

A knowledge development lifecycle for reflective practice

Reflective practice is valuable because of its potential for continuous improvement through feedback and learning. Conventional models of knowledge practice however do not explicitly include reflection as part of the practice, nor locate it in a developmental cycle. They focus on modelling in a knowledge plane which itself is contextualised by active knowing processes, and ignore the influence of power in their activity models. Further, many models focus on either an artefact or a process view, resulting from a conceptual disconnect between knowledge and knowing, and failure to relate passive to active views. Using the idea of higher order loops that govern knowledge development processes, in this paper we propose a conceptualisation of a reflective Knowledge Development Life Cycle (KDLC). This explicitly includes the investigator and the organisation itself as dynamic components of a systemic process and is suited to either a constructivist or realist epistemological stance. We describe the stages required in the KDLC and discuss their significance. Finally we show how incorporation of reflection into process enables dynamic interplay between the knowing and the knowledge in the organisation

The Noetic Prism

Definitions of ‘knowledge’ and its relationships with ‘data’ and ‘information’ are varied, inconsistent and often contradictory. In particular the traditional hierarchy of data-information-knowledge and its various revisions do not stand up to close scrutiny. We suggest that the problem lies in a flawed analysis that sees data, information and knowledge as separable concepts that are transformed into one another through processing. We propose instead that we can describe collectively all of the materials of computation as ‘noetica’, and that the terms data, information and knowledge can be reconceptualised as late-binding, purpose-determined aspects of the same body of material. Changes in complexity of noetica occur due to value-adding through the imposition of three different principles: increase in aggregation (granularity), increase in set relatedness (shape), and increase in contextualisation through the formation of networks (scope). We present a new model in which granularity, shape and scope are seen as the three vertices of a triangular prism, and show that all value-adding through computation can be seen as movement within the prism space. We show how the conceptual framework of the noetic prism provides a new and comprehensive analysis of the foundations of computing and information systems, and how it can provide a fresh analysis of many of the common problems in the management of intellectual resources

Macrophage response to Mycobacteriumtuberculosis infection

The immune response to Mycobacteriumtuberculosis (Mtb) infection is the formation of multicellular lesions, or granolomas, in the lung of the individual. However, the structure of the granulomas and the spatial distribution of the immune cells within is not well understood. In this paper we develop a mathematical model investigating the early and initial immune response to Mtb. The model consists of coupled reaction-diffusion-advection partial differential equations governing the dynamics of the relevant macrophage and bacteria populations and a bacteria-produced chemokine. Our novel application of mathematical concepts of internal states and internal velocity allows us to begin to study this unique immunological structure. Volume changes resulting from proliferation and death terms generate a velocity field by which all cells are transported within the forming granuloma. We present numerical results for two distinct infection outcomes: controlled and uncontrolled granuloma growth. Using a simplified model we are able to analytically determine conditions under which the bacteria population decreases, representing early clearance of infection, or grows, representing the initial stages of granuloma formation.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46950/1/285_2004_Article_232.pd

Bistability and Bacterial Infections

Bacterial infections occur when the natural host defenses are overwhelmed by invading bacteria. The main component of the host defense is impaired when neutrophil count or function is too low, putting the host at great risk of developing an acute infection. In people with intact immune systems, neutrophil count increases during bacterial infection. However, there are two important clinical cases in which they remain constant: a) in patients with neutropenic-associated conditions, such as those undergoing chemotherapy at the nadir (the minimum clinically observable neutrophil level); b) in ex vivo examination of the patient's neutrophil bactericidal activity. Here we study bacterial population dynamics under fixed neutrophil levels by mathematical modelling. We show that under reasonable biological assumptions, there are only two possible scenarios: 1) Bacterial behavior is monostable: it always converges to a stable equilibrium of bacterial concentration which only depends, in a gradual manner, on the neutrophil level (and not on the initial bacterial level). We call such a behavior type I dynamics. 2) The bacterial dynamics is bistable for some range of neutrophil levels. We call such a behavior type II dynamics. In the bistable case (type II), one equilibrium corresponds to a healthy state whereas the other corresponds to a fulminant bacterial infection. We demonstrate that published data of in vitro Staphylococcus epidermidis bactericidal experiments are inconsistent with both the type I dynamics and the commonly used linear model and are consistent with type II dynamics. We argue that type II dynamics is a plausible mechanism for the development of a fulminant infection

A New Model of Delirium Care in the Acute Geriatric Setting: Geriatric Monitoring Unit

<p>Abstract</p> <p>Background</p> <p>Delirium is a common and serious condition, which affects many of our older hospitalised patients. It is an indicator of severe underlying illness and requires early diagnosis and prompt treatment, associated with poor survival, functional outcomes with increased risk of institutionalisation following the delirium episode in the acute care setting. We describe a new model of delirium care in the acute care setting, titled Geriatric Monitoring Unit (GMU) where the important concepts of delirium prevention and management are integrated. We hypothesize that patients with delirium admitted to the GMU would have better clinical outcomes with less need for physical and psychotropic restraints compared to usual care.</p> <p>Methods/Design</p> <p>GMU models after the Delirium Room with adoption of core interventions from Hospital Elder Life Program and use of evening bright light therapy to consolidate circadian rhythm and improve sleep in the elderly patients. The novelty of this approach lies in the amalgamation of these interventions in a multi-faceted approach in acute delirium management. GMU development thus consists of key considerations for room design and resource planning, program specific interventions and daily core interventions. Assessments undertaken include baseline demographics, comorbidity scoring, duration and severity of delirium, cognitive, functional measures at baseline, 6 months and 12 months later. Additionally we also analysed the pre and post-GMU implementation knowledge and attitude on delirium care among staff members in the geriatric wards (nurses, doctors) and undertook satisfaction surveys for caregivers of patients treated in GMU.</p> <p>Discussion</p> <p>This study protocol describes the conceptualization and implementation of a specialized unit for delirium management. We hypothesize that such a model of care will not only result in better clinical outcomes for the elderly patient with delirium compared to usual geriatric care, but also improved staff knowledge and satisfaction. The model may then be transposed across various locations and disciplines in the acute hospital where delirious patients could be sited.</p> <p>Trial Registration</p> <p>Current Controlled Trials <a href="http://www.controlled-trials.com/ISRCTN52323811">ISRCTN52323811</a></p

The equilibria that allow bacterial persistence in human hosts

We propose that microbes that have developed persistent relationships with human hosts have evolved cross-signalling mechanisms that permit homeostasis that conforms to Nash equilibria and, more specifically, to evolutionarily stable strategies. This implies that a group of highly diverse organisms has evolved within the changing contexts of variation in effective human population size and lifespan, shaping the equilibria achieved, and creating relationships resembling climax communities. We propose that such ecosystems contain nested communities in which equilibrium at one level contributes to homeostasis at another. The model can aid prediction of equilibrium states in the context of further change: widespread immunodeficiency, changing population densities, or extinctions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62883/1/nature06198.pd