1,737 research outputs found

    Capacity Bounds and Concatenated Codes Over Segmented Deletion Channels

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    Cataloged from PDF version of article.We develop an information theoretic characterization and a practical coding approach for segmented deletion channels. Compared to channels with independent and identically distributed (i.i.d.) deletions, where each bit is independently deleted with an equal probability, the segmentation assumption imposes certain constraints, i.e., in a block of bits of a certain length, only a limited number of deletions are allowed to occur. This channel model has recently been proposed and motivated by the fact that for practical systems, when a deletion error occurs, it is more likely that the next one will not appear very soon. We first argue that such channels are information stable, hence their channel capacity exists. Then, we introduce several upper and lower bounds with two different methods in an attempt to understand the channel capacity behavior. The first scheme utilizes certain information provided to the transmitter and/or receiver while the second one explores the asymptotic behavior of the bounds when the average bit deletion rate is small. In the second part of the paper, we consider a practical channel coding approach over a segmented deletion channel. Specifically, we utilize outer LDPC codes concatenated with inner marker codes, and develop suitable channel detection algorithms for this scenario. Different maximum-a-posteriori (MAP) based channel synchronization algorithms operating at the bit and symbol levels are introduced, and specific LDPC code designs are explored. Simulation results clearly indicate the advantages of the proposed approach. In particular, for the entire range of deletion probabilities less than unity, our scheme offers a significantly larger transmission rate compared to the other existing solutions in the literature

    Hierarchical Over-the-Air Federated Edge Learning

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    Federated learning (FL) over wireless communication channels, specifically, over-the-air (OTA) model aggregation framework is considered. In OTA wireless setups, the adverse channel effects can be alleviated by increasing the number of receive antennas at the parameter server (PS), which performs model aggregation. However, the performance of OTA FL is severely limited by the presence of mobile users (MUs) located far away from the PS. In this paper, to mitigate this limitation, we propose hierarchical over-the-air federated learning (HOTAFL), which utilizes intermediary servers (IS) to form clusters near MUs. We provide a convergence analysis for the proposed setup, and demonstrate through experimental results that local aggregation in each cluster before global aggregation leads to a better performance and faster convergence than OTA FL

    Effects of Saccharomyces boulardii on antibiotic induced orocecal transit in rats

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    Clarithromycin is an antibiotic widely used for Helicobacter pylori (H. pylori) eradication and together with amoxicillin and proton pump inhibitors they constitute the first line triple treatment regimen against H. pylori. Diarrhoea is one of the major drawbacks during H. pylori eradication and is majorly attributed to clarithromycin, while Saccharomyces boulardii is a probiotic and is shown to be effective in the treatment of antibiotic associated diarrhoea. We aimed to evaluate the effect of clarithromycin on orocecal transit in rats and to identify whether the supplementation with S. boulardii has a role on orocecal transit index. Adult rats of both sexes were divided into two groups to determine immediate or chronic effects of S. boulardii and clarithromycin on orocecal transit. The first group was given single dose of the test drug, while the second group received the test drugs for one week through orogastric intubation. Both groups were randomly distributed into four subgroups; the placebo group (group A), the S. boulardii group (group B), the clarithromycin group (group C), and the co-administration that is clarithromycin plus S. boulardii group (group D). Rats were given 20 mg kg−1 clarithromycin and 500 mg kg−1S. boulardii. We did not find any difference among the subgroups in group 1, where only single dose of the test drugs was administered. In chronic administration group, that is group 2, significant differences among the subgroups were observed (P=0.004). Post-hoc comparisons of orocecal transit index between group “2A and 2C” and “2C and 2D” were significantly different (P=0.013 and P=0.005, respectively). Our results show that long term clarithromycin administration leads to rapid orocecal transit index and S. boulardii supplementation to clarithromycin can abolish this adverse effect in rats. Those findings suggest the beneficial use of S. boulardii in H. pylori eradication regimens

    One step emission tunable synthesis of PEG coated Ag 2 S NIR quantum dots and the development of receptor targeted drug delivery vehicles thereof

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    PEGylation of quantum dots (QDs) to decrease their toxicity, increase blood circulation time, reduce non-specific uptake and also to solubilize and stabilize hydrophobic QDs in aqueous medium is a widely used approach and many different methods were developed to achieve this. QDs that are luminescent in the near-infrared region (NIR) have recently emerged as the more appropriate materials for bio-imaging studies. In this work, we describe a single step emission tunable aqueous synthesis of PEGylated Ag2S NIRQDs. They are highly cytocompatible, not only due to the PEG coating but also due to the intrinsic biocompatibility of Ag2S, and prepared in a single step aqueous method using thiolated PEGs as the only coating material. Tuning the emission wavelength within the medical window (775–930 nm) with a quantum yield between 2 and 65% is achieved by changing the reaction variables such as PEG molecular weight, pH and precursor ratios. Ag2S–PEG NIRQDs prepared from 5 kDa MPEG-SH at acidic pH provided a dramatic enhancement in the luminescence intensity. These NIRQDs were also designed with surface functional groups to attach folic acid and loaded with doxorubicin (DOX) which dramatically enhanced the uptake and efficacy of DOX (50% cell death with 15 nM DOX) in FA-receptor overexpressed cancer cell lines (HeLa). They also showed a strong cytoplasmic NIR signal in the in vitro studies, demonstrating great theranostic potential

    Characterization of a broad-based mosquito yeast interfering RNA larvicide with a conserved target site in mosquito semaphorin-1a genes

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    BACKGROUND: RNA interference (RNAi), which has facilitated functional characterization of mosquito neural development genes such as the axon guidance regulator semaphorin-1a (sema1a), could one day be applied as a new means of vector control. Saccharomyces cerevisiae (baker's yeast) may represent an effective interfering RNA expression system that could be used directly for delivery of RNA pesticides to mosquito larvae. Here we describe characterization of a yeast larvicide developed through bioengineering of S. cerevisiae to express a short hairpin RNA (shRNA) targeting a conserved site in mosquito sema1a genes. RESULTS: Experiments conducted on Aedes aegypti larvae demonstrated that the yeast larvicide effectively silences sema1a expression, generates severe neural defects, and induces high levels of larval mortality in laboratory, simulated-field, and semi-field experiments. The larvicide was also found to induce high levels of Aedes albopictus, Anopheles gambiae and Culex quinquefasciatus mortality. CONCLUSIONS: The results of these studies indicate that use of yeast interfering RNA larvicides targeting mosquito sema1a genes may represent a new biorational tool for mosquito control

    Rancang Bangun Aplikasi Augmented Reality sebagai Media Promosi Model Tatanan Rambut pada Barbershop Berbasis Android

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    The development of barbershop makes business competition becomes increasingly tight. Currently, information and communication technology is very important in the field of barbershop marketing. But this technology only shows details of the existence of barbershop. In addition, the catalog of hairstyles that are provided only in the form of 2-dimensional images. Therefore, more advanced technology is needed to promote the model of hairstyle available in barbershop. One of the technology applied in smartphone applications is Augmented Reality on the Android operating system. In this research will be developed an Augmented Reality based promotion media to promote hair model model with 3 dimensional object visualization using marker based tracking method. Development of this application starts from the stage of concept creation, application design, 3-dimensional object creation, application assembly, application testing, until the application distribution stage. This application was created using C # programming language, Vuforia Qualcomm, virtual and Unity Autodeks Maya software. The application that has been produced is tested by 2 methods that is by black-box testing and by USAbility scale system test, on the test of black -box AugmentedReality application of functional barbershop that exist in the application has been successfully executed according to their respective function. Based on survey results on Usabilty ScaleSystem(SUS) test on Augmented Reality Barbershop application, 20 respondents gave average score of 73.35 with Grade Scale C
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