ON THE INCIDENCE OF THE DIFFERENT FORMS OF PRIMARY GLAUCOMA

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Monitoring settling and consolidation of fluid mud in a laboratory using ultrasonic measurements

Ultrasound measurements are routinely used to evaluate the safe depth for ships navigation - nautical depth - at waterways and ports using single-beam dual-frequency echo-sounders. The nautical depth is routinely defined by suspension density in the range of 1100–1300 kg/m3 in the mud layer. While ultrasound measurements have a weak sensitivity to density variations, calibration is always needed to convert ultrasound measurements into reliable indicators for nautical depth levels in the mud layers using densely distributed density rheological in-situ measurements. We present a laboratory ultrasonic transmission experiment to monitor the fluid mud’s settling and consolidation processes using a sample from the Port of Rotterdam. We use P- and S-wave ultrasonic transducers in the frequency range between 200 to 1000 kHz. Our results show that the P-wave velocities slightly increase during the consolidation and settling process while the P-wave amplitudes decrease. On the other hand, we observe a high S-wave velocity that increases together with amplitudes over time. The P- and S-wave amplitude and S-wave velocity variation over time correlate well with the mud average density variation. The presented results can be very useful for fluid-mud monitoring at a lab scale, besides possible utilization for large-scale monitoring field campaigns

Illumination diagnosis for retrieval of reflections from ambient-noise seismic data in the Siilinjärvi mining site, Finland

Reflection seismic methods are becoming popular in mineral exploration, because they allow high-resolution delineation of the exploration targets, even at great depths. Seismic interferometry can be used to retrieve reflections from passive seismic data, removing the need for active seismic sources and, therefore, reducing the cost and environmental impact of exploration. The retrieval of reflections can be challenging, since passive seismic records are typically dominated by surface waves. Therefore, illumination diagnosis, a method which allows the isolation of the portions of the passive data where body-wave signals are stronger, can be a valuable step that improves the quality of the reflections retrieved from seismic interferometry and reduces the overall computational cost of the processing stage. Here, we validate the performance of the method to effectively isolate the portions of the passive data dominated by body waves and apply it on an ambient-noise seismic dataset acquired in the Siilinjärvi mining site in Finland

Pharmacogenetics of paraoxonases: a brief review

The human paraoxonase (PON) gene family consists of three members, PON1 , PON2 , and PON3 , aligned next to each other on chromosome 7. By far the most-studied member of the family is the serum paraoxonase 1 (PON1), a high-density lipoprotein-associated esterase/lactonase. Early research focused on its capability to hydrolyze toxic organophosphates, and its name derives from one of its most commonly used in vitro substrates, paraoxon. Studies in the last 2 decades have demonstrated PON1’s ability to protect against atherosclerosis by hydrolyzing specific derivatives of oxidized cholesterol and/or phospholipids in oxidized low-density lipoprotein and in atherosclerotic lesions. Levels and genetic variability of PON1 influence sensitivity to specific insecticides and nerve agents, as well as the risk of cardiovascular disease. More recently, the other two members of the PON family, PON2 and PON3, have also been shown to have antioxidant properties. A major goal in present research on the paraoxonases is to identify their natural substrates and to elucidate the mechanism(s) of their catalytic activities.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46312/1/210_2003_Article_833.pd

Early perioperative res ults in 53 cases of locally rec urrent colorectal cancer

Purpose: The objective of this study was to analyze retrospectively the early perioperative results in a cohort of 53 patients with localy reccurent colorectal cancer (CRC).Material and methods: The study covered 53 patients with CRC 21 males and 32 females at a mean age of 62 years treated in the Clinic of Liver, Biliary, Pancreatic and General Surgery, Tokuda Hospital of Sofia, during the period from January 2007 to March 2013. Any necessary diagnostic and surgical methods were applied.Results: The locally recurrent CRC is a challenge for the surgeon because of the fact that in most cases it engages adjacent anatomical structures and organs, on the one hand, and it is accompanied by complications, on the other hand.Conclusion: Achievement of good late results in patients with recurrent CRC is due to radicality of the interventions. Most often, they should be multivisceral resections. The presence of intestinal obstruction of varying degree and of synchronous peritoneal and liver metastases commonly limit the possibilities for surgical interference with the disease. Particular attention should be paid to possible neoadjuvant treatment capable of reducing the stage of diasease and improving the perioperative outcomes. Therapeutic behaviour should be strictly individual and consider any possible options. The experience of the surgical team is extremely important, too

Multivisceral ‘en-bloc` resections of colorectal tumours - milestones in the surgical techniques

Purpose: Colorectal tumours (CRT) consisting mainly of colorectal cancer (CRC) are diagnosed sometimes at an advanced T4 stage, i. e. local involvement of neighbouring organ/organs and anatomical structure/ structures. Aggressive surgical approach preceded and/or followed by neo-adjuvant/adjuvant therapy is advocated because of proven benefit for the patient. The aim of this study was to carry out a literature survey, on the one hand, and to analyze the cases from the authors` institutional experience, on the other hand, in an attempt to submit for consideration the milestones of the multivisceral en-block resections in cases of locally advanced CRTs, i.e. to describe the specific surgical approaches depending on different tumour location and peritumoural involvement of adjacent structures and organs.Material and methods: A retrospective analysis of 154 cases of CRT was performed, all of them operated in the Clinic of Liver, Biliary, Pancreatic and General Surgery, Tokuda Hospital of Sofia, from January 1, 2007 to March 31, 2013. All the patients were diagnosed in an advanced T4-stage and received multivisceral en-bloc resections. Three main groups of methods that had been used were analyzed: 1) preoperative diagnosis, giving a hint of multivisceral en-bloc resection; 2) intraoperative assessment - gross tumour appearance, frozen sections (?), final histological examinations, and 3) surgical methods.Results: Early morbidity and mortality rates were 22,6% and 5,8%, respectively, without any significant difference when compared with ‘simple` colon and rectum resections and with literature data available.Conclusion: Multivisceral en-bloc resection for CRCs has been performed in more than 10% of the cases. It benefits the long-term prognosis. Tumour location and number of resected organs are essential characteristics of these procedures and they are independently associated with the quantity of intraoperative blood loss, higher early morbidity rates and more frequent local recurrence

Locally advanced adenocarcinoma of the supramesocolic part of the colon . Feat ures of surgical treatment and challenges

Purpose: The objective of the present study was to analyze the early results from the surgical treatment of locally advanced carcinoma of the colon in its transverse section and the two flexures.Material and methods: The study covered 36 patients with locally advanced colonic carcinoma, 19 males and 17 females at a mean age of 65,6 years, treated in the Clinic of Liver, Biliary, Pancreatic and General Surgery, Tokuda Hospital of Sofia during the period from January 2007 to March 2013. Any necessary diagnostic and surgical methods were applied.Results: Multivisceral resections were commonly performed in order to achieve a radical surgery in cases of locally advanced disease. Great surgeon`s experience in liver, biliary and pancreatic interventions is obligatorily required. In this paper we share our experience in the treatment of this disease for a period of 6 years.Conclusion: Our application of the multivisceral resections results in surgical radicality along with acceptable levels of perioperative morbidity and mortality rates when compared to other studies in in the foreign literature available