Conserved quantities in isotropic loop quantum cosmology

We develop an action principle for those models arising from isotropic loop quantum cosmology, and show that there is a natural conserved quantity $Q$ for the discrete difference equation arising from the Hamiltonian constraint. This quantity $Q$ relates the semi-classical limit of the wavefunction at large values of the spatial volume, but opposite triad orientations. Moreover, there is a similar quantity for generic difference equations of one parameter arising from a self-adjoint operator.Comment: 6 pages, to be published in Europhysics Letter

Numerical loop quantum cosmology: an overview

A brief review of various numerical techniques used in loop quantum cosmology and results is presented. These include the way extensive numerical simulations shed insights on the resolution of classical singularities, resulting in the key prediction of the bounce at the Planck scale in different models, and the numerical methods used to analyze the properties of the quantum difference operator and the von Neumann stability issues. Using the quantization of a massless scalar field in an isotropic spacetime as a template, an attempt is made to highlight the complementarity of different methods to gain understanding of the new physics emerging from the quantum theory. Open directions which need to be explored with more refined numerical methods are discussed.Comment: 33 Pages, 4 figures. Invited contribution to appear in Classical and Quantum Gravity special issue on Non-Astrophysical Numerical Relativit

The Quantum Configuration Space of Loop Quantum Cosmology

The article gives an account of several aspects of the space known as the Bohr compactification of the line, featuring as the quantum configuration space in loop quantum cosmology, as well as of the corresponding configuration space realization of the so-called polymer representation. Analogies with loop quantum gravity are explored, providing an introduction to (part of) the mathematical structure of loop quantum gravity, in a technically simpler context.Comment: 14 pages. Minor changes, typos corrected, 1 reference added. To appear in Class. Quantum Gra

Asymptotic Properties of Difference Equations for Isotropic Loop Quantum Cosmology

In loop quantum cosmology, a difference equation for the wave function describes the evolution of a universe model. This is different from the differential equations that arise in Wheeler-DeWitt quantizations, and some aspects of general properties of solutions can appear differently. Properties of particular interest are boundedness and the presence of small-scale oscillations. Continued fraction techniques are used to show in different matter models the presence of special initial conditions leading to bounded solutions, and an explicit expression for these initial values is derived.Comment: 27 pages, 2 figure

Perturbative Degrees of Freedom in Loop Quantum Gravity: Anisotropies

The relation between an isotropic and an anisotropic model in loop quantum cosmology is discussed in detail, comparing the strict symmetry reduction with a perturbative implementation of symmetry. While the latter cannot be done in a canonical manner, it allows to consider the dynamics including the role of small non-symmetric degrees of freedom for the symmetric evolution. This serves as a model for the general situation of perturbative degrees of freedom in a background independent quantization such as loop quantum gravity, and for the more complicated addition of perturbative inhomogeneities. While being crucial for cosmological phenomenology, it is shown that perturbative non-symmetric degrees of freedom do not allow definitive conclusions for the singularity issue and in such a situation could even lead to wrong claims.Comment: 32 page

Spherically Symmetric Quantum Geometry: Hamiltonian Constraint

Variables adapted to the quantum dynamics of spherically symmetric models are introduced, which further simplify the spherically symmetric volume operator and allow an explicit computation of all matrix elements of the Euclidean and Lorentzian Hamiltonian constraints. The construction fits completely into the general scheme available in loop quantum gravity for the quantization of the full theory as well as symmetric models. This then presents a further consistency check of the whole scheme in inhomogeneous situations, lending further credence to the physical results obtained so far mainly in homogeneous models. New applications in particular of the spherically symmetric model in the context of black hole physics are discussed.Comment: 33 page

Nicotine replacement therapy for agitation and delirium management in the intensive care unit: a systematic review of the literature.

BACKGROUND: Active smokers are prevalent within the intensive care setting and place a significant burden on healthcare systems. Nicotine withdrawal due to forced abstinence on admission may contribute to increased agitation and delirium in this patient group. The aim of this systematic review was to determine whether management of nicotine withdrawal, with nicotine replacement therapy (NRT), reduces agitation and delirium in critically ill patients admitted to the intensive care unit (ICU). METHODS: The following sources were used in this review: MEDLINE, EMBASE, and CINAHL Plus databases. Included studies reported delirium or agitation outcomes in current smokers, where NRT was used as management of nicotine withdrawal, in the intensive care setting. Studies were included regardless of design or number of participants. Data were extracted on ICU classification; study design; population baseline characteristics; allocation and dose of NRT; agitation and delirium assessment methods; and the frequency of agitation, delirium, and psychotropic medication use. RESULTS: Six studies were included. NRT was mostly prescribed for smokers with heavier smoking histories. Three studies reported an association between increased agitation or delirium and NRT use; one study could not find any significant benefit or harm from NRT use; and two described a reduction of symptomatic nicotine withdrawal. A lack of consistent and validated assessment measures, combined with limitations in the quality of reported data, contribute to conflicting results. CONCLUSIONS: Current evidence for the use of NRT in agitation and delirium management in the ICU is inconclusive. An evaluation of risk versus benefit on an individual patient basis should be considered when prescribing NRT. Further studies that consider prognostic balance, adjust for confounders, and employ validated assessment tools are urgently needed

On (Cosmological) Singularity Avoidance in Loop Quantum Gravity

Loop Quantum Cosmology (LQC), mainly due to Bojowald, is not the cosmological sector of Loop Quantum Gravity (LQG). Rather, LQC consists of a truncation of the phase space of classical General Relativity to spatially homogeneous situations which is then quantized by the methods of LQG. Thus, LQC is a quantum mechanical toy model (finite number of degrees of freedom) for LQG(a genuine QFT with an infinite number of degrees of freedom) which provides important consistency checks. However, it is a non trivial question whether the predictions of LQC are robust after switching on the inhomogeneous fluctuations present in full LQG. Two of the most spectacular findings of LQC are that 1. the inverse scale factor is bounded from above on zero volume eigenstates which hints at the avoidance of the local curvature singularity and 2. that the Quantum Einstein Equations are non -- singular which hints at the avoidance of the global initial singularity. We display the result of a calculation for LQG which proves that the (analogon of the) inverse scale factor, while densely defined, is {\it not} bounded from above on zero volume eigenstates. Thus, in full LQG, if curvature singularity avoidance is realized, then not in this simple way. In fact, it turns out that the boundedness of the inverse scale factor is neither necessary nor sufficient for curvature singularity avoidance and that non -- singular evolution equations are neither necessary nor sufficient for initial singularity avoidance because none of these criteria are formulated in terms of observable quantities.After outlining what would be required, we present the results of a calculation for LQG which could be a first indication that our criteria at least for curvature singularity avoidance are satisfied in LQG.Comment: 34 pages, 16 figure

Acute kidney disease and renal recovery : consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup

Consensus definitions have been reached for both acute kidney injury (AKI) and chronic kidney disease (CKD) and these definitions are now routinely used in research and clinical practice. The KDIGO guideline defines AKI as an abrupt decrease in kidney function occurring over 7 days or less, whereas CKD is defined by the persistence of kidney disease for a period of > 90 days. AKI and CKD are increasingly recognized as related entities and in some instances probably represent a continuum of the disease process. For patients in whom pathophysiologic processes are ongoing, the term acute kidney disease (AKD) has been proposed to define the course of disease after AKI; however, definitions of AKD and strategies for the management of patients with AKD are not currently available. In this consensus statement, the Acute Disease Quality Initiative (ADQI) proposes definitions, staging criteria for AKD, and strategies for the management of affected patients. We also make recommendations for areas of future research, which aim to improve understanding of the underlying processes and improve outcomes for patients with AKD