The Herts and Minds study: feasibility of a randomised controlled trial of Mentalizationbased Treatment versus usual care to support the wellbeing of children in foster care

© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.Background: There is a lack of well-designed randomized controlled trials (RCTs) to investigate the efficacy of psychological therapies for children in foster care with emotional and behavioural difficulties. Mentalization-based therapy (MBT) focuses on supporting the carer-child relationship by promoting reflective capacity. This study examined the feasibility and acceptability of an RCT of MBT, delivered in a family-format, for children who are in foster care in the UK. Method: Herts and Minds was a phase II, blinded feasibility RCT with follow-up of at 12 and 24 weeks post-randomisation. Participants were children (age 5-16) in foster care referred to a targeted mental health service, who had some level of difficulty as identified by the Strengths and Difficulties Questionnaire (SDQ). Aims were to assess: the feasibility of recruitment processes and study uptake; capacity to train mental health practitioners to deliver MBT to an acceptable level of treatment integrity; establish acceptability and credibility of MBT as an intervention for children in foster care; establish feasibility and acceptability to participants of conducting an RCT; and estimate the likely treatment efficacy effect size. Participants were randomly allocated to either MBT (n = 15) or Usual Clinical Care (UCC) (n = 21) individually or in sibling groups. A range of qualitative and quantitative data was gathered to assess feasibility. Results: Feasibility was established with regard to: capacity to recruit participants to a study; capacity to train mental health practitioners to deliver MBT to an acceptable level of treatment integrity; acceptability and credibility of MBT; and feasibility and acceptability to participants of conducting an RCT. A number of issues made it difficult to estimate a likely treatment efficacy effect size. Conclusion: With modifications, it is feasible to run an RCT of MBT for children in foster care. Both the therapy and research design were acceptable to participants, but modifications may be needed regarding both the timing of assessments and the identification of appropriate primary outcome measures. Given the lack of evidenced based therapies for this population, such a trial would be a significant contribution to the field. Findings may be useful for other groups planning clinical trials of psychological therapies for children in foster care. Trial registration: ISRCTN 90349442. The trial was retrospectively registered on 6 May 2016.Peer reviewedFinal Published versio

Coupling biochemistry and mechanics in cell adhesion: a model for inhomogeneous stress fiber contraction

Biochemistry and mechanics are closely coupled in cell adhesion. At sites of cell-matrix adhesion, mechanical force triggers signaling through the Rho-pathway, which leads to structural reinforcement and increased contractility in the actin cytoskeleton. The resulting force acts back to the sites of adhesion, resulting in a positive feedback loop for mature adhesion. Here we model this biochemical-mechanical feedback loop for the special case when the actin cytoskeleton is organized in stress fibers, which are contractile bundles of actin filaments. Activation of myosin II molecular motors through the Rho-pathway is described by a system of reaction-diffusion equations, which are coupled into a viscoelastic model for a contractile actin bundle. We find strong spatial gradients in the activation of contractility and in the corresponding deformation pattern of the stress fiber, in good agreement with experimental findings.Comment: Revtex, 35 pages, 13 Postscript figures included, in press with New Journal of Physics, Special Issue on The Physics of the Cytoskeleto

Electrochemical synthesis of ammonia from N2 and H2O based on (Li,Na,K)2CO3-Ce0.8Gd 0.18Ca0.02O2-δ composite electrolyte and CoFe2O4 cathode

Electrochemical synthesis of ammonia from water vapour and nitrogen was investigated using an electrolytic cell based on CoFe2O 4-Ce0.8Gd0.18Ca0.02O 2-δ (CFO-CGDC), CGDC-ternary carbonate composite and Sm 0.5Sr0.5CoO3-δ-Ce0.8Gd 0.18Ca0.02O2-δ (SSCo-CGDC) as cathode, electrolyte and anode respectively. CoFe2O4, CGDC and SCCo were prepared via a combined EDTA-citrate complexing sol-gel and characterised by X-ray diffraction (XRD). The AC ionic conductivities of the CGDC-carbonate composite were investigated under three different atmospheres (air, dry O 2 and wet 5% H2-Ar). A tri-layer electrolytic cell was fabricated by a cost-effective one-step dry-pressing and co-firing process. Ammonia was successfully synthesised from water vapour and nitrogen under atmospheric pressure and the maximum rate of ammonia production was found to be 6.5 × 10-11 mol s-1 cm-2 at 400 C and 1.6 V which is two orders of magnitude higher than that of previous report when ammonia was synthesised from N2 and H2O at 650 C

Predicting Space Weather Effects on Close Approach Events

The NASA Robotic Conjunction Assessment Risk Analysis (CARA) team sends ephemeris data to the Joint Space Operations Center (JSpOC) for conjunction assessment screening against the JSpOC high accuracy catalog and then assesses risk posed to protected assets from predicted close approaches. Since most spacecraft supported by the CARA team are located in LEO orbits, atmospheric drag is the primary source of state estimate uncertainty. Drag magnitude and uncertainty is directly governed by atmospheric density and thus space weather. At present the actual effect of space weather on atmospheric density cannot be accurately predicted because most atmospheric density models are empirical in nature, which do not perform well in prediction. The Jacchia-Bowman-HASDM 2009 (JBH09) atmospheric density model used at the JSpOC employs a solar storm active compensation feature that predicts storm sizes and arrival times and thus the resulting neutral density alterations. With this feature, estimation errors can occur in either direction (i.e., over- or under-estimation of density and thus drag). Although the exact effect of a solar storm on atmospheric drag cannot be determined, one can explore the effects of JBH09 model error on conjuncting objects' trajectories to determine if a conjunction is likely to become riskier, less risky, or pass unaffected. The CARA team has constructed a Space Weather Trade-Space tool that systematically alters the drag situation for the conjuncting objects and recalculates the probability of collision for each case to determine the range of possible effects on the collision risk. In addition to a review of the theory and the particulars of the tool, the different types of observed output will be explained, along with statistics of their frequency

Multilocus sequence typing of pathogenic treponemes isolated from cloven-hoofed animals and comparison to treponemes isolated from humans

Treponema species are implicated in many diseases of humans and animals. Digital dermatitis (DD) treponemes are reported to cause severe lesions in cattle, sheep, pigs, goats, and wild elk, causing substantial global animal welfare issues and economic losses. The fastidiousness of these spirochetes has previously precluded studies investigating within-phylogroup genetic diversity. An archive of treponemes that we isolated enabled multilocus sequence typing to quantify the diversity and population structure of DD treponemes. Isolates (n = 121) were obtained from different animal hosts in nine countries on three continents. The analyses herein of currently isolated DD treponemes at seven housekeeping gene loci confirm the classification of the three previously designated phylogroups: the Treponema medium, Treponema phagedenis, and Treponema pedis phylogroups. Sequence analysis of seven DD treponeme housekeeping genes revealed a generally low level of diversity among the strains within each phylogroup, removing the need for the previously used "-like" suffix. Surprisingly, all isolates within each phylogroup clustered together, regardless of host or geographic origin, suggesting that the same sequence types (STs) can infect different animals. Some STs were derived from multiple animals from the same farm, highlighting probable within-farm transmissions. Several STs infected multiple hosts from similar geographic regions, identifying probable frequent between-host transmissions. Interestingly, T. pedis appears to be evolving more quickly than the T. medium or T. phagedenis DD treponeme phylogroup, by forming two unique ST complexes. The lack of phylogenetic discrimination between treponemes isolated from different hosts or geographic regions substantially contrasts with the data for other clinically relevant spirochetes

Neighbourhood, Route and Workplace-Related Environmental Characteristics Predict Adults' Mode of Travel to Work

Commuting provides opportunities for regular physical activity which can reduce the risk of chronic disease. Commuters' mode of travel may be shaped by their environment, but understanding of which specific environmental characteristics are most important and might form targets for intervention is limited. This study investigated associations between mode choice and a range of objectively assessed environmental characteristics.Participants in the Commuting and Health in Cambridge study reported where they lived and worked, their usual mode of travel to work and a variety of socio-demographic characteristics. Using geographic information system (GIS) software, 30 exposure variables were produced capturing characteristics of areas around participants' homes and workplaces and their shortest modelled routes to work. Associations between usual mode of travel to work and personal and environmental characteristics were investigated using multinomial logistic regression.Of the 1124 respondents, 50% reported cycling or walking as their usual mode of travel to work. In adjusted analyses, home-work distance was strongly associated with mode choice, particularly for walking. Lower odds of walking or cycling rather than driving were associated with a less frequent bus service (highest versus lowest tertile: walking OR 0.61 [95% CI 0.20–1.85]; cycling OR 0.43 [95% CI 0.23–0.83]), low street connectivity (OR 0.22, [0.07–0.67]; OR 0.48 [0.26–0.90]) and free car parking at work (OR 0.24 [0.10–0.59]; OR 0.55 [0.32–0.95]). Participants were less likely to cycle if they had access to fewer destinations (leisure facilities, shops and schools) close to work (OR 0.36 [0.21–0.62]) and a railway station further from home (OR 0.53 [0.30–0.93]). Covariates strongly predicted travel mode (pseudo r-squared 0.74).Potentially modifiable environmental characteristics, including workplace car parking, street connectivity and access to public transport, are associated with travel mode choice, and could be addressed as part of transport policy and infrastructural interventions to promote active commuting

Phase transitions for PP-adic Potts model on the Cayley tree of order three

In the present paper, we study a phase transition problem for the $q$-state $p$-adic Potts model over the Cayley tree of order three. We consider a more general notion of $p$-adic Gibbs measure which depends on parameter \rho\in\bq_p. Such a measure is called {\it generalized $p$-adic quasi Gibbs measure}. When $\rho$ equals to $p$-adic exponent, then it coincides with the $p$-adic Gibbs measure. When $\rho=p$, then it coincides with $p$-adic quasi Gibbs measure. Therefore, we investigate two regimes with respect to the value of $|\rho|_p$. Namely, in the first regime, one takes $\rho=\exp_p(J)$ for some J\in\bq_p, in the second one $|\rho|_p<1$. In each regime, we first find conditions for the existence of generalized $p$-adic quasi Gibbs measures. Furthermore, in the first regime, we establish the existence of the phase transition under some conditions. In the second regime, when $|\r|_p,|q|_p\leq p^{-2}$ we prove the existence of a quasi phase transition. It turns out that if $|\r|_p<|q-1|_p^2<1$ and \sqrt{-3}\in\bq_p, then one finds the existence of the strong phase transition.Comment: 27 page

Making Sense of a New Transport System: An Ethnographic Study of the Cambridgeshire Guided Busway

An increase in public transport use has the potential to contribute to improving population health, and there is growing interest in innovative public transport systems. Yet how new public transport infrastructure is experienced and integrated (or not) into daily practice is little understood. We investigated how the Cambridgeshire Guided Busway, UK, was used and experienced in the weeks following its opening, using the method of participant observation (travelling on the busway and observing and talking to passengers) and drawing on Normalization Process Theory to interpret our data. Using excerpts of field notes to support our interpretations, we describe how the ease with which the new transport system could be integrated into existing daily routines was important in determining whether individuals would continue to use it. It emerged that there were two groups of passengers with different experiences and attitudes. Passengers who had previously travelled frequently on regular bus services did not perceive the new system to be an improvement; consequently, they were frustrated that it was differentiated from and not coherent with the regular system. In contrast, passengers who had previously travelled almost exclusively by car appraised the busway positively and perceived it to be a novel and superior form of travel. Our rich qualitative account highlights the varied and creative ways in which people learn to use new public transport and integrate it into their everyday lives. This has consequences for the introduction and promotion of future transport innovations. It is important to emphasise the novelty of new public transport, but also the ways in which its use can become ordinary and routine. Addressing these issues could help to promote uptake of other public transport interventions, which may contribute to increasing physical activity and improving population health. © 2013 Jones et al

Analysis of Gas-Phase Clusters Made from Laser-Vaporized Icosahedral Al−Pd−Mn

An icosahedral Al−Pd−Mn quasicrystal sample is laser vaporized to form metal clusters by gas aggregation. The clusters are subsequently laser ionized and mass analyzed in a time-of-flight mass spectrometer. The mass spectra show cluster compositions which are qualitatively similar to that of the sample. This is consistent with a kinetically controlled cluster growth process. Cluster thermodynamic stability is probed by multiphoton ionization/fragmentation, which induces primarily Al and Mn loss. The resulting spectra are composed of a series of Pd-rich Al−Pd clusters. The average cluster composition is 60 (±1)% Pd. This composition is close to a known eutectic in the Al−Pd system. When manganese is seen on these clusters, it is always in units of Mn3. These results are discussed in terms of relative binding strengths in the Al−Pd−Mn alloy system