Flood Risk Mapping and Management in Urban Areas: Integrating Geomatics and Hydrodynamic Modeling - A Case Study of Al Bidi City, Saudi Arabia

In this paper, we focus on developing a comprehensive approach to map and manage flood risks in Al Bidi City, located in the Al-Aflaj Governorate of Saudi Arabia. By integrating geomatics (Remote Sensing and GIS) and hydrodynamic modeling (PCSWMM and HEC-RAS), the study aims to simulate and model flood risks in populated areas under different scenarios, considering the impact of climate change. The study generates three integrated maps: flood intensity, environmental sensitivity, and flood risks. Strategic solutions and mitigation measures are proposed based on the findings. The results indicate that Al Bidi City is exposed to flood risks originating from the west and progressing towards the east, primarily due to significant valleys such as Wadi Harm. Approximately 60% of the urban area is affected by torrential water. The study proposes the construction of embankments, channels, and culverts to redirect floodwaters to Wadi Al Jadwal in the east, as well as the implementation of industrial channels to manage floods in the northern valleys

A wideband 3-dB directional coupler in GGW for use in V-Band communication systems

In this article, a broadband 3-dB directional coupler is proposed using groove gap waveguide (GGW) structures. Gap waveguide technology has been introduced to overcome manufacturing and assembling challenges of different millimeter-wave components and devices. The presented coupler has wideband coupling flatness with low return loss in 60-GHz frequency band and can be easily adapted to other frequency ranges. Experimentally, a sample prototype of the proposed 3-dB coupler has been designed and fabricated. The measured return loss and isolation are better than 20 dB and the power-split unbalance within \ub10.5 dB is obtained over the frequency range from 57 to 74 GHz (26% BW). The proposed structure has the capability of easily integrating with other millimeter-wave components

Pollutant Removal from Highway Runoff Using Retention/Detention Units

Highway runoff contains total suspended solids, hydrocarbons, oil and greases, chloride, and other contaminants that are transported in solution and particulate forms to adjacent floodplains, roadside swales, and retention/detention ponds. Oil and grit chambers represent a type of retention/detention unit used for removing heavy particulates and adsorbed hydrocarbon particulates. Storage/sediment units also represent a type of retention/detention unit used for controlling peak flow and removing suspended solids. The aim of this study is to evaluate the effect of traffic volume and site characteristics on highway runoff quality. The study also aims to evaluate the performance of retention/detention units that collect runoff from the Prague-Brno and Prague-Plzeň highways, Czech Republic. The results of this study indicate no definitive relationship between average daily traffic and concentration of runoff constituents, though the site characteristics have a strong relation to some constituents. The results also show that retention/detention units are effective in treating organic compounds

Axiomatic/asymptotic evaluation of multilayered plate theories by using single and multi-points error criteria

AbstractThis paper deals with refined theories for multilayered composites plates. Layer-Wise (LW) and Equivalent Single Layer (ESL) theories are evaluated by means of axiomatic–asymptotic approach. Theories with forth order displacement fields in the thickness layer/plate direction z are implemented by referring to the Unified Formulation by Carrera. The effectiveness of each term of the made expansion is evaluated by comparing the related theories with a reference solution. As a result a reduced model is obtained which preserve the accuracy of the full-model (model that include the whole terms of the z-expansion) but it removes the not-significant terms in the same expansion (those terms that do no improve the results according to a given error criteria). Various single-point and multi-point error criteria have been analyzed and compared in order to establish such an effectiveness: error localized in an assigned point along z, error localized at each interface, error located at the z-value corresponding to the maximum value of the considered variables, etc. Applications are given in case of closed form solutions of orthotropic cross-ply, rectangular, simply supported plates loaded by bisinusoidal distribution of transverse pressure. Symmetrically and unsymmetrical laminated cases are considered along with sandwich plates. It is found the reduced model is strongly influenced by the used localized error and that in same case the reduced model which is obtained by of single point criteria can be very much improved by the use of multi-point criteria

Fob1 and Fob2 Proteins Are Virulence Determinants of Rhizopus oryzae via Facilitating Iron Uptake from Ferrioxamine.

Dialysis patients with chronic renal failure receiving deferoxamine for treating iron overload are uniquely predisposed for mucormycosis, which is most often caused by Rhizopus oryzae. Although the deferoxamine siderophore is not secreted by Mucorales, previous studies established that Rhizopus species utilize iron from ferrioxamine (iron-rich form of deferoxamine). Here we determined that the CBS domain proteins of Fob1 and Fob2 act as receptors on the cell surface of R. oryzae during iron uptake from ferrioxamine. Fob1 and Fob2 cell surface expression was induced in the presence of ferrioxamine and bound radiolabeled ferrioxamine. A R. oryzae strain with targeted reduced Fob1/Fob2 expression was impaired for iron uptake, germinating, and growing on medium with ferrioxamine as the sole source of iron. This strain also exhibited reduced virulence in a deferoxamine-treated, but not the diabetic ketoacidotic (DKA), mouse model of mucormycosis. The mechanism by which R. oryzae obtains iron from ferrioxamine involves the reductase/permease uptake system since the growth on ferrioxamine supplemented medium is associated with elevated reductase activity and the use of the ferrous chelator bathophenanthroline disulfonate abrogates iron uptake and growth on medium supplemented with ferrioxamine as a sole source of iron. Finally, R. oryzae mutants with reduced copies of the high affinity iron permease (FTR1) or with decreased FTR1 expression had an impaired iron uptake from ferrioxamine in vitro and reduced virulence in the deferoxamine-treated mouse model of mucormycosis. These two receptors appear to be conserved in Mucorales, and can be the subject of future novel therapy to maintain the use of deferoxamine for treating iron-overload

ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The µ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy.

Background:Pain management with conventional opioids can be challenging due to dose-limiting adverse events (AEs), some of which may be related to the simultaneous activation of β-arrestin (a signaling pathway associated with opioid-related AEs) and G-protein pathways. The investigational analgesic oliceridine is a G-protein-selective agonist at the µ-opioid receptor with less recruitment of β-arrestin. The objective of this phase 3, open-label, multi-center study was to evaluate the safety and tolerability, of IV oliceridine for moderate to severe acute pain in a broad, real-world patient population, including postoperative surgical patients and non-surgical patients with painful medical conditions. Methods:Adult patients with a score ≥4 on 11-point NRS for pain intensity received IV oliceridine either by bolus or PCA; multimodal analgesia was permitted. Safety was assessed using AE reports, study discontinuations, clinical laboratory and vital sign measures. Results:A total of 768 patients received oliceridine. The mean age (SD) was 54.1 (16.1) years, with 32% ≥65 years of age. Most patients were female (65%) and Caucasian (78%). Surgical patients comprised the majority of the study population (94%), most common being orthopedic (30%), colorectal (15%) or gynecologic (15%) procedures. Multimodal analgesia was administered to 84% of patients. Oliceridine provided a rapid reduction in NRS pain score by 2.2 ± 2.3 at 30 mins from a score of 6.3 ± 2.1 (at baseline) which was maintained to the end of treatment. No deaths or significant cardiorespiratory events were reported. The incidence of AEs leading to early discontinuation and serious AEs were 2% and 3%, respectively. Nausea (31%), constipation (11%), and vomiting (10%) were the most common AEs. AEs were mostly of mild (37%) or moderate (25%) severity and considered possibly or probably related to oliceridine in 33% of patients. Conclusion:Oliceridine IV for the management of moderate to severe acute pain was generally safe and well tolerated in the patients studied. ClinicalTrialsgov identifier:NCT02656875

A new strain-based finite element for plane elasticity problems

Purpose The purpose of this paper is to develop a new quadrilateral strain-based element. The element has five nodes, four at the corners as well as an internal node. Design/methodology/approach Through the introduction of the internal node, the numerical performance of the element proved to be superior to existing elements in the literature, even though a static condensation is required. Findings From several numerical examples, it is shown that convergence can be achieved with the use of only a small number of finite elements. The proposed element can be used to solve general plane linear elasticity problems resulting in excellent results. Originality/value The results obtained are comparable with those given by the robust element Q8

The serial blocking effect: a testbed for the neural mechanisms of temporal-difference learning

Temporal-difference (TD) learning models afford the neuroscientist a theory-driven roadmap in the quest for the neural mechanisms of reinforcement learning. The application of these models to understanding the role of phasic midbrain dopaminergic responses in reward prediction learning constitutes one of the greatest success stories in behavioural and cognitive neuroscience. Critically, the classic learning paradigms associated with TD are poorly suited to cast light on its neural implementation, thus hampering progress. Here, we present a serial blocking paradigm in rodents that overcomes these limitations and allows for the simultaneous investigation of two cardinal TD tenets; namely, that learning depends on the computation of a prediction error, and that reinforcing value, whether intrinsic or acquired, propagates back to the onset of the earliest reliable predictor. The implications of this paradigm for the neural exploration of TD mechanisms are highlighted