Evolution of Genetic Potential

Organisms employ a multitude of strategies to cope with the dynamical environments in which they live. Homeostasis and physiological plasticity buffer changes within the lifetime of an organism, while stochastic developmental programs and hypermutability track changes on longer timescales. An alternative long-term mechanism is “genetic potential”—a heightened sensitivity to the effects of mutation that facilitates rapid evolution to novel states. Using a transparent mathematical model, we illustrate the concept of genetic potential and show that as environmental variability decreases, the evolving population reaches three distinct steady state conditions: (1) organismal flexibility, (2) genetic potential, and (3) genetic robustness. As a specific example of this concept we examine fluctuating selection for hydrophobicity in a single amino acid. We see the same three stages, suggesting that environmental fluctuations can produce allele distributions that are distinct not only from those found under constant conditions, but also from the transient allele distributions that arise under isolated selective sweeps

Mapping swirls and pseudo-spines of compact 4-manifolds

AbstractA compact subset X of the interior of a compact manifold M is a pseudo-spine of M if M − X is homeomorphic to (∂M) × [0, ∞). It is proved that a 4-manifold obtained by attaching k essential 2-handles to a B3 × S1 has a pseudo-spine which is obtained by attaching k B2's to an S1 by maps of the form z → zn. This result recovers the fact that the Mazur 4-manifold has a disk pseudo-spine (which may then be shrunk to an arc). To prove this result, the mapping swirl (a “swirled” mapping cylinder) of a map to a circle is introduced, and a fundamental property of mapping swirls is established: homotopic maps to a circle have homeomorphic mapping swirls.Several conjectures concerning the existence of pseudo-spines in compact 4-manifolds are stated and discussed, including the following two related conjectures: every compact contractible 4-manifold has an arc pseudo-spine, and every compact contractible 4-manifold has a handlebody decomposition with no 3- or 4-handles. It is proved that an important class of compact contractible 4-manifolds described by Poénaru satisfies the latter conjecture

Random Networks with Tunable Degree Distribution and Clustering

We present an algorithm for generating random networks with arbitrary degree distribution and Clustering (frequency of triadic closure). We use this algorithm to generate networks with exponential, power law, and poisson degree distributions with variable levels of clustering. Such networks may be used as models of social networks and as a testable null hypothesis about network structure. Finally, we explore the effects of clustering on the point of the phase transition where a giant component forms in a random network, and on the size of the giant component. Some analysis of these effects is presented.Comment: 9 pages, 13 figures corrected typos, added two references, reorganized reference

On manifolds with nonhomogeneous factors

We present simple examples of finite-dimensional connected homogeneous spaces (they are actually topological manifolds) with nonhomogeneous and nonrigid factors. In particular, we give an elementary solution of an old problem in general topology concerning homogeneous spaces

An Epidemiological Network Model for Disease Outbreak Detection

Most surveillance systems are not robust to shifts in health care utilization. Ben Reis and colleagues developed network models that detected localized outbreaks better and were more robust to unpredictable shifts