5 research outputs found
Portuguese: A Posiiio do Brasil no Tocante Efetivaaao do Parlamento do Mercosul (Brazil's Position Regarding Effectiveness of Mercosur's Parliament)
Los Derechos de los Extranjeros en Situación Irregular: Reflexiones a la Luz de la Práctica de los Sistemas de Protección de Derechos Humanos en el Ambito Europeo y Americano (The Rights of Undocumented Migrants in the Light of Recent International Practice in Europe and America)
Networks, Courts and Regional Integration: Explaining the Establishment of the Andean Court of Justice
Clinical and in vitro
Treatment of infections caused by Burkholderia cepacia complex (Bcc) in cystic fibrosis (CF) patients poses a complex problem. Bcc is multidrug-resistant due to innate and acquired mechanisms of resistance. As CF patients receive multiple courses of antibiotics, susceptibility patterns of strains from CF patients may differ from those noted in strains from non-CF patients. Thus, there was a need for assessing in vitro and clinical data to guide antimicrobial therapy in these patients. A systematic search of literature, followed by extraction and analysis of available information from human and in vitro studies was done. The results of the analysis are used to address various aspects like use of antimicrobials for pulmonary and non-pulmonary infections, use of combination versus monotherapy, early eradication, duration of therapy, route of administration, management of biofilms, development of resistance during therapy, pharmacokinetics–pharmacodynamics correlations, therapy in post-transplant patients and newer drugs in Bcc-infected CF patients