Diseño de un sistema de gestión de calidad basado en la norma ISO 9001:2015 para mejorar la satisfacción del cliente de la empresa Inmobicorp S. A. C.

El presente trabajo de investigación tiene por objetivo el diseño de un Sistema de Gestión de Calidad basado en la Norma ISO 9001:2015, para mejorar la satisfacción del cliente de la empresa Inmobicorp S.A.C. Para lo cual, se desarrolló un diagnóstico situacional de la empresa usando técnicas como entrevistas con el personal, encuesta a los clientes, check list (pre y post diseño), y diagrama de Ishikawa. Los primeros resultados obtenidos del check list fueron que la organización cumplía a un 32% de la norma, y como resultado promedio de la encuesta de satisfacción del cliente tipo A y tipo B fue de 60% evidenciando deficiencias en la trazabilidad de sus procesos, atención oportunidad y adecuada del servicio y conocimiento de los procedimientos por parte de los involucrados en el proceso de intermediación. El diseño del SGC se basó en la elaboración de documentos tales como procedimientos y formatos orientados al cumplimiento normativo y de los requisitos del cliente, enfocados a la mejora continua. Luego de realizado el diseño, los resultados de un post check list de cumplimiento fueron del 100% en base a la norma, mostrando una variación positiva de 68% en cuento al primer diagnóstico, además en base a otras investigaciones luego de la aplicación del diseño, se espera una satisfacción del cliente mayor a 90%

Isolation and Characterization of Microsatellites Markers in Centaurium Grandiflorum ssp. Boissieri

Background: Estimating outcrossing/selfing rates and characterizing genetic diversity with microsatellite markers are crucial to understanding the evolution of plant mating systems. Methods and results: We developed, optimized and characterized eight new primer pairs for Centaurium grandiflorum ssp. boissieri and transferred them to three subspecies of Centaurium quadrifolium. Two SSR loci were transferred from Sabatia campestris to the four Centaurium taxa. Polymorphisms, He, Ho and H–W deviations were estimated in two populations of C. grandiflorum ssp. boissieri and in seven individuals each of C. quadrifolium ssp. barrelieri, C. quadrifolium ssp. parviflorum and C. quadrifolium ssp. quadrifolium. A total of 80 individuals was used in these experiments. The number of polymorphic loci varied among species from one to ten. A total of 127 alleles was scored. The average number of alleles per locus was 12.7. He was higher than Ho in all sampled populations. Hardy–Weinberg equilibrium was found for some loci in different species. Conclusions: This is the first report of microsatellites successfully amplified in the whole Centaurium genus. They will be valuable for estimating mating system parameters and genetic diversity and exploring their relationships with the wide variation in flower morphology in the genus, especially anther-stigma separation.Consejo Nacional de Ciencia y Tecnología #252042Ministerio de Economia, Industria y Competitividad CGL2013-45037-PMinisterio de Ciencia e Innovación PGC2018-099608-B-10

Prevalence of oral lesions in patients with psoriasis

Aim: To determine the prevalence of oral lesions (OL) in patients with psoriasis, and compare these findings with the ones found in patients without this condition. Materials and methods: In the present observational and comparative study, we evaluated 207 patients, with and without psoriasis, attending the dermatological consulting service of a concentration hospital in Mexico City. The possible association between OL and psoriasis was analyzed through a logistic regression model; the Odds Ratio (OR) and its Confidence Interval (CI) was calculated to be 95%. Results: Two hundred and seven cases were examined (80 with psoriasis and 127 without psoriasis). Of these, 75 (36.2%) were men and 132 (63.7%) women. Oral lesions were found in 54 (67.5%) psoriatic patients and in 63 (49.6%) of the comparative group (p 0.05) regarding the use of tobacco. Alcohol consumption was greater (55.0%) among patients with psoriasis than among those without psoriasis (26.7%) (p 0.05). Conclusions: The high prevalence of GT and FT in patients with psoriasis suggests that these lesions should be taken into account in new studies as possible predictors or markers of the severity of this dermatosis, in order to confirm the association of these entities

Nutritional status and high adherence to the mediterranean diet in colombian school children and teenagers during the COVID-19 pandemic according to sex

La actual pandemia de COVID-19 ha generado una serie de cambios en las rutinas diarias de las personas, incluidos niños y adolescentes, de una forma sin precedentes, lo que constituye un desafío mundial en salud pública. El aislamiento social ha sido una medida profiláctica para evitar la propagación del virus; sin embargo, ha generado impactos negativos en la salud física y emocional de padres, cuidadores, niños y adolescentes alrededor del mundo. El objetivo del presente estudio fue evaluar los efectos del confinamiento provocado por la pandemia del COVID-19 a nivel del estado nutricional, patrones dietéticos y de comportamiento de niños y adolescentes de educación básica primaria de una pequeña localidad de Colombia. Se evaluaron parámetros antropométricos como IMC Z-score, perímetro de cintura y relación cintura/talla en 266 escolares y adolescentes. Se aplicó un cuestionario con características sociodemográficas, clínicas y de estilo de vida y el KIDMED para conocer aspectos nutricionales. Un total de 102 estudiantes (38⋅3 %) fueron clasificados con estado nutricional alterado, siendo 39 (14⋅7 %) clasificados con sobrepeso y 36 (13⋅5 %) con obesidad. La prevalencia de alta adherencia a la dieta mediterránea fue del 12 %, IC 95 % (0⋅08, 0⋅16). El sobrepeso fue más frecuente en mujeres (26/39, 66⋅7 %; P = 0⋅0439), y la obesidad fue discretamente más frecuente en hombres (19/36, 52⋅7 %; P = 0⋅7193). Observamos una situación nutricional, dietética y comportamental preocupante en los niños y adolescentes estudiados durante el confinamiento asociado a la pandemia de COVID-19. Esto devela la necesidad de establecer estrategias y/o políticas públicas en nuestra localidad que ayuden a promover un adecuado desarrollo biopsicosocial del paciente pediátrico y su grupo familiar.The current COVID-19 pandemic has generated a series of changes in the daily routines of people, including children and teenagers, in an unprecedented way, which constitutes a global challenge in public health. Social isolation has been a prophylactic measure to prevent the spread of the virus; however, it has generated negative impacts on the physical and emotional health of parents, caregivers, children and teenagers around the world. The objective of the present study was to evaluate the effects of confinement caused by the COVID-19 pandemic at the level of nutritional status, dietary and behavioural patterns of elementary school children and teenagers in a small town of Colombia. Anthropometric parameters such as BMI Z-score, waist circumference and waist/height ratio were evaluated in 266 school children and teenagers. A questionnaire with socio-demographic, clinical and lifestyle characteristics and the KIDMED were applied to learn about nutritional aspects. A total of 102 students (38⋅3 %) were classified as having altered nutritional status, being 39 (14⋅7 %) classified as overweight and 36 (13⋅5 %) with obesity. The prevalence of high adherence to the Mediterranean diet was 12 %, 95 % CI (0⋅08, 0⋅16). Overweight was more prevalent in women (26/39, 66⋅7 %; P = 0⋅0439), and obesity was discreetly more frequent in men (19/36, 52⋅7 %; P = 0⋅7193). We observed a worrying nutritional, dietary and behavioural situation in the children and teenagers studied during the confinement associated with the COVID-19 pandemic. This unveils the need to establish strategies and/or public policies in our town that help to promote an adequate biopsychosocial development of the paediatric patient and their family grou

Phenolic Compounds in Organic and Aqueous Extracts from Acacia farnesiana Pods Analyzed by ULPS-ESI-Q-oa/TOF-MS. In Vitro Antioxidant Activity and Anti-Inflammatory Response in CD-1 Mice

Abstract: Background: Acaciafarnesiana (AF) pods have been traditionally used to treat dyspepsia, diarrhea and topically for dermal inflammation. Main objectives: (1) investigate the antioxidant activity and protection against oxidative-induced damage of six extracts from AF pods and (2) their capacitytocurbtheinflammationprocessaswellastodown-regulatethepro-inflammatorymediators. Methods: Five organic extracts (chloroformic, hexanic, ketonic, methanolic, methanolic:aqueous and one aqueous extract) were obtained and analyzed by UPLC-ESI-Q-oa/TOF-MS. Antioxidant activity (DPPH•, ORAC and FRAP assays) and lipid peroxidation (TBARS assay) were performed. Assessmentofanti-inflammatorypropertieswasmadebytheearedemainducedmodelinCD-1mice andMPOactivityassay. Likewise,histologicalanalysis,IL-1β,IL-6,IL-10,TNF-α,COXmeasurements plus nitrite and immunohistochemistry analysis were carried out. Results: Methyl gallate, gallic acid,galloyl glucose isomer 1, galloyl glucose isomer 2, galloyl glucose isomer 3, digalloyl glucose isomer 1, digalloyl glucose isomer 2, digalloyl glucose isomer 3, digalloyl glucose isomer 4, hydroxytyrosol acetate, quinic acid, and caffeoylmalic acid were identified. Both organic and aqueous extracts displayed antioxidant activity. All extracts exhibited a positive effect on the interleukins, COX and immunohistochemistry assays. Conclusion: All AF pod extracts can be effective as antioxidant and topical anti-inflammatory agents. Keywords: Acacia farnesiana pods; antioxidant and anti-inflammatory activities; bioactive compounds; polyphenol

De la impotencia al poder-no. Tópicos de la resistencia en la cultura iberoamericana

La pujante presencia de Iberoamérica en el ámbito geopolítico, así como en la literatura y las artes a nivel global, es indiscutible en nuestros días. A partir de ello, cobra vigencia analizar ciertos tópicos culturales de la demarcación. El marco teórico posestructuralista añade grandes posibilidades reflexivas al escrutinio investigativo. Gilles Deleuze y Félix Guattari, junto con Giorgio Agamben son los principales pensadores que introducen los ejes paradigmáticos de los estudios aquí reunidos, los cuales son producto de la colaboración internacional entre académicos de la Universidad Autónoma del Estado de México y la Universidad Pontificia Bolivariana de Medellín, Colombia, a través de la Red de investigación “Crítica a las manifestaciones del poder: violencia y resistencia”.Universidad Autónoma del Estado de Méxic

PDGF-BB serum levels are decreased in adult onset Pompe patients

Adult onset Pompe disease is a genetic disorder characterized by slowly progressive skeletal and respiratory muscle weakness. Symptomatic patients are treated with enzymatic replacement therapy with human recombinant alfa glucosidase. Motor functional tests and spirometry are commonly used to follow patients up. However, a serological biomarker that correlates with the progression of the disease could improve follow-up. We studied serum concentrations of TGFβ, PDGF-BB, PDGF-AA and CTGF growth factors in 37 adult onset Pompe patients and 45 controls. Moreover, all patients performed several muscle function tests, conventional spirometry, and quantitative muscle MRI using 3-point Dixon. We observed a statistically significant change in the serum concentration of each growth factor in patients compared to controls. However, only PDGF-BB levels were able to differentiate between asymptomatic and symptomatic patients, suggesting its potential role in the follow-up of asymptomatic patients. Moreover, our results point to a dysregulation of muscle regeneration as an additional pathomechanism of Pompe disease

Epigenetic clocks in relapse after a first episode of schizophrenia

The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p = 0.030). Shorter telomere length was associated with cognitive performance (working memory, r = 0.31 p = 0.015; verbal fluency, r = 0.28 p = 0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages

The Caldera. No. 23

La pandemia, sin lugar a dudas, nos ha cambiado la vida a todos; un viernes nos fuimos para nuestros hogares, en el marco de una educación presencial; al lunes siguiente, después de dos días, estábamos iniciando el camino hacia una educación remota, una educación virtual, que se ha convertido en una gran alternativa para seguir contribuyendo con la formación de nuestros niños y jóvenes caldistas y al mejoramiento de nuestra calidad de vida que halla, en la educación, nuevamente la respuesta; han sido meses de cambios drásticos, inimaginables pero, cambios positivos que nos han permitido crecer como individuos, como familia, como escuela y como sociedad.Especial pandemia. Una generación Resiliente por promoción DINASTIA…06 VII Concurso Intercolegiado departamental de Oratoria. Ulibro 2020…51 Deporte en el Caldas…64 Expresiones Caldistas…71 Celebremos la palabra…93 Nuestros Maestros…102 Galería de Imágenes…107The pandemic, without a doubt, has changed the lives of all of us; One Friday we went to our homes, as part of a face-to-face education; The following Monday, after two days, we were starting the path towards a remote education, a virtual education, which has become a great alternative to continue contributing to the training of our children and young Caldistas and to the improvement of our quality of life. that finds, in education, the answer again; They have been months of drastic changes, unimaginable but positive changes that have allowed us to grow as individuals, as a family, as a school and as a society

Resultados Semilleros de Investigación 2009-2010

La publicación recoge los doce informes finales de investigación presentados por los estudiantes de ocho Semilleros 1 y cuatro Semilleros 2, correspondientes a la convocatoria 2009–2010 y se constituye en el Número 25 de la Serie de Investigaciones en Construcción, si bien este es el primer Número publicado en formato digital que UNIJUS se permite poner a disposición no sólo de la comunidad universitaria, sino también de la sociedad colombiana e internacional, interesada en los temas estudiados por los jóvenes investigadores de la Facultad de Derecho, Ciencias Políticas y Sociales de la Universidad Nacional de Colombia